血清IL-33在胃癌中的研究进展
Research Progress of Serum IL-33 in Gastric Cancer
DOI: 10.12677/ACM.2023.131148, PDF,   
作者: 王庆庆, 陈思言:西安医学院,陕西 西安;刘丹平*:陕西省人民医院,陕西 西安
关键词: 白介素-33胃癌抑制致瘤性2受体Interleukin-33 Suppression of Tumorigenicity 2
摘要: IL-33被认为是机体的“警报素”,在人类肿瘤组织内皮细胞的细胞核中大量表达,激活多种炎症介质,通过细胞传导途径促进或抑制肿瘤发生。越来越多的证据表明IL-33参与了肿瘤的发展进程。文章通过IL-33的作用机制、与炎症细胞之间的联系和肿瘤浸润、增殖、耐药、预后等方面阐述了IL-33在胃癌方面的影响,为胃癌的潜在靶点提供理论基础。
Abstract: IL-33 is considered to be the “alarm sign” of the body and is expressed in substantial amounts in the nuclei of human tumor tissue endothelial cells, activating a variety of inflammatory mediators that promote or inhibit tumorigenesis through cellular transduction pathways. There is growing evi-dence that IL-33 plays a role in the development of tumors. The article illustrates the impact of IL-33 in gastric cancer by examining the mechanism of action, the connection with inflammatory cells, as well as tumor infiltration, proliferation, drug resistance, and prognosis, serving theoretical basis for targeted treatment of gastric cancer.
文章引用:王庆庆, 刘丹平, 陈思言. 血清IL-33在胃癌中的研究进展[J]. 临床医学进展, 2023, 13(1): 1067-1072. https://doi.org/10.12677/ACM.2023.131148

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