布鲁顿酪氨酸激酶(BTK)抑制剂对原发性中枢神经系统淋巴瘤的疗效综述
Review of the Efficacy of Bruton Tyrosine Kinase (BTK) Inhibitors on Primary Central Nervous System Lymphoma
摘要: 原发性中枢神经系统淋巴瘤(PCNSL)是一种罕见的侵袭性淋巴结外非霍奇金淋巴瘤,目前基于甲氨蝶呤的大剂量化疗是新诊断的PCNSL的标准诱导治疗方案,但其在老年PCNSL的有效治疗仍不明确。随着临床试验的进行,不断出现新的药物和联合治疗方法,较多的临床试验证实BTK抑制剂在PCNSL的治疗中显示出良好的缓解率,本综述将重点介绍BTK抑制剂在PCNSL中的作用机制及现有临床试验结果,以期为真实世界原发性中枢神经系统淋巴瘤患者的个体化治疗提供参考依据。
Abstract: Primary central nervous system lymphoma (PCNSL) is a rare and aggressive extranodal non-Hodg- kin’s lymphoma. Methotrexate-based high-dose chemotherapy is currently the standard induction therapy for newly diagnosed PCNSL, but its effective treatment in elderly PCNSL remains unclear. As clinical trials continue to emerge with new drugs and combination therapies, more clinical trials have confirmed that BTK inhibitors show good remission rates in the treatment of PCNSL. This re-view will focus on the mechanism of action of BTK inhibitors in PCNSL and the results of available clinical trials, with the aim of providing a reference for the individualized treatment of patients with real-world primary central nervous system lymphoma.
文章引用:周卓如, 高大. 布鲁顿酪氨酸激酶(BTK)抑制剂对原发性中枢神经系统淋巴瘤的疗效综述[J]. 临床医学进展, 2023, 13(1): 1083-1091. https://doi.org/10.12677/ACM.2023.131150

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