老年男性骨质疏松的危险因素——基于686人的横断面研究

Risk Factors for Osteoporosis in Elderly Men—Based on Across-Sectional Study of 638 Men

摘要: 目的：探讨老年男性发生骨质疏松(Osteoporosis, OP)的相关危险因素。方法：回顾性分析2017年1月~2019年12月在我院行骨密度(BMD)检查的686例老年男性的临床资料，并根据BMD T值将其分为3组：骨质正常组，骨量减少组和骨质疏松组，比较3组患者的年龄、BMI、血压、生化指标等情况，分析引起骨量减少以及骨质疏松的危险因素。结果：三组受试者在年龄、BMI和UA水平方面存在显著差异(均P < 0.05)，而在舒张压、收缩压、25(OH)D3和HDL-C上差异无统计学意义(均P > 0.05)；老年男性BMD T值与年龄和HDL-C (r = -0.143, P < 0.001)呈负相关，而与BMI (r = 0.119, P = 0.002)、舒张压(r = 0.157, P < 0.001)、收缩压(r = 0.142, P < 0.001)、25(OH)D3 (r = 0.083, P < 0.030)和UA (r = 0.133, P < 0.001)呈正相关；年龄(OR = 1.076, 95%CI = 1.046~1.106, P < 0.001)被确定为老年男性OP的独立危险因素，BMI (OR = 0.858, 95%CI = 0.793~0.928, P < 0.001)和UA (OR = 0.995, 95%CI = 0.991~0.998, P = 0.001)则被确定为保护因素。结论：老年男性OP可能与高龄、低BMI以及低UA水平密切相关。

Abstract: Objective: To explore the related risk factors of osteoporosis (OP) in elderly men. Methods: By ana-lyzing the clinical data of 686 elderly men who underwent bone mineral density (BMD) examination in our hospital from January 2017 to December 2019, which were divided into 3 groups according to the BMD T value: normal bone group, osteopenia group and osteoporosis group, we compare the age, BMI, blood pressure, and biochemical indicators of the three groups of patients to analyze the risk factors for osteopenia and osteoporosis. Results: There were significant differences in age, BMI and UA levels among the three groups (all P < 0.05), but no significant differences in diastolic blood pressure, systolic blood pressure, 25(OH)D3 and HDL-C (all P > 0.05). The value of BMD T in elderly men was negatively correlated with age and HDL-C (r = -0.143, P < 0.001), but positively correlated with BMI (r = 0.119, P < 0.001), diastolic blood pressure (r = 0.157, P < 0.001), systolic blood pres-sure (r = 0.142, P < 0.001), 25(OH)D3 (r = 0.083, P < 0.030) and UA (r = 0.133, P < 0.001). Age (OR = 1.076, 95%CI = 1.046~1.106, P < 0.001) was identified as an independent risk factor for OP in older men, BMI (OR = 0.858, 95%CI = 0.793~0.928, P < 0.001) and UA (OR = 0.995, 95%CI = 0.991~0.998, P = 0.001) was determined as a protective factor. Conclusion: OP in older men may be closely relat-ed to advanced age, low BMI, and low UA levels.