肿瘤与男性不育症的相关性研究进展

Research Progress on the Correlation between Tumors and Male Reproductive Function

摘要: 生育能力与肿瘤在过去总与女性联系密切，但最近的研究表明生育功能差的男性各种恶性肿瘤的风险较高，主要是泌尿生殖系统恶性肿瘤。生育功能和恶性肿瘤之间的联系是多因素的，但确切的机制解释仍不完全清楚，且有越来越多的数据支持使男性不育和恶性肿瘤的特定机制可能包括癌症的自身免疫、内分泌和压力的影响，以及组织发育不全、DNA修复错配和基因有关。随着年轻肿瘤患者生存率的提高，对生育力的保护变得更为重要，但肿瘤的产生及进展都可能导致男性生育功能不可逆的损伤，甚至不育，因此本文就肿瘤与男性生育功能的相关性进行综述，以提供理论依据。

Abstract: Fertility and tumors have always been closely associated with women in the past, but recent studies have shown that men with poor fertility are at higher risk of various malignancies, mainly genitou-rinary malignancies. The link between fertility and malignancy is multifactorial, but the exact mechanistic explanation is still not fully understood, and there is growing data to support specific mechanisms that contribute to male infertility and malignancy, which may include the effects of autoimmune, endocrine, and stress in cancer, as well as tissue hypoplasia, DNA repair mismatches, and gene involvement. With the improvement of the survival rate of young tumor patients, the protection of fertility becomes more important, but the emergence and progression of tumors may lead to irreversible damage to male fertility and even infertility, so this paper reviews the correla-tion between tumors and male fertility function to provide theoretical basis.