宫颈癌放疗敏感性的相关影响因素研究进展
Research Progress on the Factors Affecting Radiotherapy Sensitivity of Cervical Cancer
DOI: 10.12677/ACM.2023.132267, PDF,   
作者: 张 珍, 赵化荣*：新疆医科大学第一附属医院肿瘤中心一科，新疆 乌鲁木齐
关键词: 宫颈癌；放疗敏感性；辐射耐受性；Cervical Cancer； Radiotherapy Sensitivity； Radiation Tolerance
摘要: 宫颈癌在全球女性恶性肿瘤中的发病率排名第四，是女性癌症相关死亡的第二大主要原因。尽管近年来，各国逐渐完善了宫颈癌癌前病变系统性的筛查以及人们进行HPV疫苗的接种，但往往诊断时大多数已是中晚期。同步放化疗是局部晚期宫颈癌的标准治疗方案，部分宫颈癌患者表现出对辐射的抵抗，从而导致不良的预后，因此，如何提高宫颈癌放疗疗效，降低宫颈癌细胞放射抵抗性成为了如今研究的关键切入点。宫颈癌的放疗敏感性通常与基因表达、RNA调控、肿瘤微环境及免疫疗法等多种因素有关。虽然其中有些机制尚未完全明确，但其对宫颈癌治疗及预后上有很大的应用前景。
Abstract: Cervical cancer is the fourth most common malignancy in women worldwide and the second leading cause of cancer-related death in women. Although in recent years, countries have gradually im-proved the systematic screening of cervical cancer precancerous lesions and people to carry out HPV vaccination, but often the diagnosis is already in the middle and advanced stage. Synchronized chemoradiotherapy is the standard treatment for locally advanced cervical cancer, and some cervi-cal cancer patients show resistance to radiation, leading to poor prognosis. Therefore, how to im-prove the curative effect of cervical cancer radiotherapy and reduce the radiation resistance of cer-vical cancer cells has become a key entry point for current research. The radiotherapy sensitivity of cervical cancer is usually related to gene expression, RNA regulation, tumor microenvironment and immunotherapy. Although some of these mechanisms are not fully understood, they have great ap-plication prospects in the treatment and prognosis of cervical cancer.
文章引用：张珍, 赵化荣. 宫颈癌放疗敏感性的相关影响因素研究进展[J]. 临床医学进展, 2023, 13(2): 1933-1939. https://doi.org/10.12677/ACM.2023.132267

参考文献

[1] 郑荣涛, 孙可欣, 张思维, 等. 2015年中国恶性肿瘤流行情况分析[J]. 中华肿瘤杂志, 2019, 41(1): 19-28
[2] Cohen, P.A., Jhingran, A., Oaknin, A. and Denny, L. (2019) Cervical Cancer. Lancet, 393, 169-182. [Google Scholar] [CrossRef] 
[3] 施璠, 汪涛, 王娟, 张莹冰, 苏进, 刘孜. 宫颈癌组织中Survivin、UHRF1 mRNA表达及其与宫颈癌放疗敏感性的相关性[J]. 西安交通大学学报(医学版), 2020, 41(1): 23-26
[4] Li, J.-L., Wang, J.-P., Chang, H., Deng, S.-M., et al. (2019) FEN1 Inhibitor Increases Sensitivity of Radio-therapy in Cervical Cancer Cells. Cancer Medicine, 8, 7774-7780. [Google Scholar] [CrossRef] [PubMed]
[5] Brummelman, J., Pilipow, K. and Lugli, E. (2018) The Single-Cell Pheno-typic Identity of Human CD8+ and CD4+ T Cells. International Review of Cell and Molecular Biology, 341, 63-124. [Google Scholar] [CrossRef] [PubMed]
[6] Mohd Shukri, N.D., Farah Izati, A., Wan Ghazali ,W.S., Che Hussin, C.M. and Wong, K.K. (2021) CD3+CD4+gp130+ T Cells Are Associated With Worse Disease Activity in Sys-temic Lupus Erythematosus Patients. Frontiers in Immunology, 12, Article 675250. [Google Scholar] [CrossRef] [PubMed]
[7] Zander, R., Schauder, D., Xin, G., Nguyen, C., Wu, X., Zajac, A. and Cui, W. (2019) CD4+ T Cell Help Is Required for the Formation of a Cytolytic CD8+ T Cell Subset That Protects against Chronic Infection and Cancer. Immunity, 51, 1028-1042. [Google Scholar] [CrossRef] [PubMed]
[8] 王永刚, 黄莉, 范佩文, 冯亚宁, 王若峥. 宫颈癌TIGIT表达与临床特征关联性分析[J]. 中华肿瘤防治杂志, 2020, 27(20): 1657-1663.
[9] Das, D., Sarkar, B., Mukhopadhyay, S., Banerjee, C. and Biswas Mondal, S. (2018) An Altered Peripheral Blood—A Prognostic Clue? Asian Pacific Journal of Cancer Prevention, 19, 471-447.
[10] Tsuchiya, T., Someya, M., Takada, Y., Hasegawa, T., Kitagawa, M., Fukushima, Y., Gocho, T., Hori, M., Nakata, K., Hirohashi, Y., Torigoe, T., Saito, T. and Sakata, K.I. (2020) Association between Radiotherapy-Induced Alteration of Programmed Death Ligand 1 and Survival in Patients with Uterine Cervical Cancer Undergoing Preoperative Radiotherapy. Strahlen-therapie und Onkologie, 196, 725-735. [Google Scholar] [CrossRef] [PubMed]
[11] He, Y., Li, X.-M., Yin, C.-H. and Wu, Y.M. (2020) Killing Cervical Cancer Cells by Specific Chimeric Antigen Receptor-Modified T Cells. Journal of Reproductive Immunology, 139, Article ID: 103115. [Google Scholar] [CrossRef] [PubMed]
[12] 杨科, 何平, 屈敏, 等. 7野调强与9野调强的骨髓限量放疗对晚期宫颈癌患者骨髓抑制的影响[J]. 湖南师范大学学报(医学版), 2020, 17(2): 76-78. [Google Scholar] [CrossRef] 
[13] Das, D., Sarkar, B., Mukhopadhyay, S., Banerjee, C. and Biswas Mondal, S. (2018) An Altered Ratio of CD4+ And CD8+ T Lymphocytes in Cervical Cancer Tissues and Pe-ripheral Blood—A Prognostic Clue? Asian Pacific Journal of Cancer Prevention, 19, 471-478.
[14] 陈娟, 付虹霞. 恩度联合放、化疗对中晚期宫颈癌疗效及CD4+T细胞平衡失调的影响[J]. 肿瘤药学, 2020, 10(6): 709-713.
[15] Ye, S., Sun, X., Kang, B., Wu, F., Zheng, Z., Xiang, L., Lesénéchal, M., Heskia, F., Liang, J. and Yang, H. (2020) The Ki-netic Profile and Clinical Implication of SCC-Ag in Squamous Cervical Cancer Patients Undergoing Radical Hysterec-tomy Using the Simoa Assay: A Prospective Observational Study. BMC Cancer, 20, Article No. 138. [Google Scholar] [CrossRef] [PubMed]
[16] Martens-Uzunova, E.S., Bottcher, R., Croce, C.M., Jenster, G., Visakorpi, T. and Calin, G.A. (2014) Long Noncoding RNA in Prostate, Bladder, and Kidney Cancer. European Urolo-gy, 65, 1140-1151. [Google Scholar] [CrossRef] [PubMed]
[17] Li, J., Sun, S., Chen, W. andYuan, K. (2019) Small Nucleolar RNA Host Gene 12 (SNHG12) Promotes Proliferation and Invasion of Laryngeal Cancer Cells via Sponging miR-129-5p and Potentiating WW Domain-Containing E3 Ubiquitin Protein Ligase 1 (WWP1) Expression. Medical Sci-ence Monitor, 25, 5552-5560. [Google Scholar] [CrossRef] 
[18] Zhang, H. and Lu, W. (2018) LncRNA SNHG12 Regulates Gastric Cancer Progression by Acting as a Molecular Sponge of miR320. Molecular Medicine Reports, 17, 2743-2749. [Google Scholar] [CrossRef] [PubMed]
[19] Wang, C., Shao, S., Deng, L., Wang, S. and Zhang, Y. (2020) LncRNA SNHG12 Regulates the Radiosensitivity of Cervical Cancer through the miR-148a/CDK1 Pathway. Cancer Cell International, 20, Article No. 554. [Google Scholar] [CrossRef] [PubMed]
[20] Zhang, Y., Sun, B., Zhao, L., Liu, Z., Xu, Z., Tian, Y., et al. (2019) Up-Regulation of miRNA-148a Inhibits Proliferation, Invasion, and Migration While Promoting Apoptosis of Cervical Cancer Cells by Down-Regulating RRS1. Bioscience Reports, 39, Article ID: BSR20181815. [Google Scholar] [CrossRef] 
[21] Ai, Z., Lu, Y., Qiu, S. and Fan, Z. (2016) Overcoming Cisplatin Re-sistance of Ovarian Cancer Cells by Targeting HIF-1-Regulated Cancer Metabolism. Cancer Letters, 373, 36-44. [Google Scholar] [CrossRef] [PubMed]
[22] Harada, H. (2011) How Can We Overcome Tumor Hypoxia in Radiation Therapy? Journal of Radiation Research, 52, 545-556. [Google Scholar] [CrossRef] [PubMed]
[23] Li, S., Wei, Q., Li, Q., Zhang, B. and Xiao, Q. (2015) Down-Regulating HIF-1α by Lentivirus-Mediated shRNA for Therapy of Tri-ple Negative Breast Cancer. Cancer Biology & Therapy, 16, 866-875. [Google Scholar] [CrossRef] [PubMed]
[24] Dellas, K., Bache, M., Pigorsch, S.U., Taubert, H., Kappler, M., Holzapfel, D., Zorn, E., Holzhausen, H.J. and Haensgen, G. (2008) Prognostic Impact of HIF-1α Expression in Pa-tients with Definitive Radiotherapy for Cervical Cancer. Strahlentherapie und Onkologie, 184, 169-174. [Google Scholar] [CrossRef] [PubMed]
[25] Chen, F.-J., Sun, M., Li, S.-Q., et al. (2013) Upregulation of the Long Non-Coding RNA HOTAIR Promotes Esophageal Squamous Cell Carcinoma Metastasis and Poor Prognosis. Molecular Carcinogenesis, 52, 908-915. [Google Scholar] [CrossRef] [PubMed]
[26] Liu, M., Jia, J., Wang, X., Liu, Y., Wang, C. and Fan, R. (2018) Long Non-Coding RNA HOTAIR Promotes Cervical Cancer Progression through Regulating BCL2 via Targeting miR143-3p. Cancer Biology & Therapy, 19, 391-399. [Google Scholar] [CrossRef] [PubMed]
[27] Huang, L., Liao, L.-M., Liu, A.-W., Liu, A-W., Wu, J.-B., Cheng, X.-L., Lin, J.-X., et al. (2014) Overexpression of Long Noncoding RNA HOTAIR Predicts a Poor Prognosis in Patients with Cervical Cancer. Archives of Gynecology and Obstetrics, 290, 717-723. [Google Scholar] [CrossRef] [PubMed]
[28] Zhou, Y.-H., Cui, Y.-H., Wang, T. and Luo, Y. (2020) Long Non-Coding RNA HOTAIR in Cervical Cancer: Molecular Marker, Mechanistic Insight, and Therapeutic Target. Ad-vances in Clinical Chemistry, 97, 117-140. [Google Scholar] [CrossRef] [PubMed]
[29] Cho, H., Lee, Y.S., Kim, J., Chung, J.-Y. and Kim, J.-H. (2013) Overexpression of Glucose Transporter-1 (GLUT-1) Predicts Poor Prognosis in Epithelial Ovarian Cancer. Cancer In-vestigation, 31, 607-615. [Google Scholar] [CrossRef] [PubMed]
[30] Yu, M., et al. (2017) The Prognostic Value of GLUT1 in Cancers: A Systematic Review and Meta-Analysis. Oncotarget, 8, 43356-43367. [Google Scholar] [CrossRef] [PubMed]
[31] Qian, X., Zhao, J., Yeung, P.Y., Zhang, Q.C. and Kwok, C.K. (2019) Revealing lncRNA Structures and Interactions by Sequencing-Based Approaches. Trends in Biochemical Scienc-es, 44, 33-52. [Google Scholar] [CrossRef] [PubMed]
[32] Kanjanapan, Y., et al. (2017) Glut-1 Expression in Small Cervical Biopsies Is Prognostic in Cervical Cancers Treated with Chemoradiation. Clinical and Translational Radiation Oncology, 2, 53-58. [Google Scholar] [CrossRef] [PubMed]

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