不同结缔组织病相关间质性肺病临床特点研究进展
Research Progress on Clinical Characteristics of Interstitial Lung Disease Associated with Different Connective Tissue Diseases
DOI: 10.12677/ACM.2023.132279, PDF,   
作者: 阿依尼尕尔·阿布力孜, 刘 晖*：新疆医科大学第一附属医院呼吸三科，新疆 乌鲁木齐
关键词: 结缔组织病；间质性肺病；免疫抑制剂；Connective Tissue Disease； Interstitial Lung Disease； Immunosuppressor
摘要: 结缔组织病(connective tissue disease, CTD)是多系统、多器官受累的自身免疫性疾病，自身免疫抗体的紊乱通过诱导肺成纤维细胞分化及内皮细胞血管生成等一系列复杂的机制参与了肺纤维化的发生和发展。然而，不同类型的结缔组织病所继发的间质性肺病(Interstitial lung diseases, ILDs)之间是否具有明显差异尚未明确。因此，本文结合国内外最新文献及实验研究，对不同类型结缔组织病所致的间质性肺病进行对比探讨，为结缔组织病相关间质性肺病(connective tissue disease associ-ated interstitial lung disease, CTD-ILD)的诊疗寻找更多新思维。
Abstract: Connective tissue disease is a multisystem and multiorgan involved autoimmune disease. The con-nective tissue disorder is involved in the occurrence and development of pulmonary fibrosis by in-ducing lung fibroblast differentiation and endothelial cell angiogenesis and a series of complex mechanisms. However, it is not clear whether there is a significant difference between Interstitial lung diseases (ILDs) secondary to different types of connective tissue diseases. Therefore, this paper combined with the latest literature and experimental studies at home and abroad to compare and discuss the interstitial lung disease caused by different types of connective tissue diseases to find out more new thinking about the diagnosis and treatment of connective tissue associated intersti-tial lung disease (CTD-ILD).
文章引用：阿依尼尕尔·阿布力孜, 刘晖. 不同结缔组织病相关间质性肺病临床特点研究进展[J]. 临床医学进展, 2023, 13(2): 2006-2011. https://doi.org/10.12677/ACM.2023.132279

参考文献

[1] 卢喜烈, 杨庭树. 内科学[M]. 第9版人卫版. 上海: 上海科学技术文献出版社, 2021.
[2] 何渝娇. 91例间质性肺疾病患者临床特征及中医证候分析[D]: [硕士学位论文]. 乌鲁木齐: 新疆医科大学, 2020.
[3] 郭红敏. 不同结缔组织病肺间质病变(CTD-ILD)的临床特点及治疗效果[J]. 中国保健营养, 2016, 26(16): 136.
[4] 王妍华, 蒲丹, 罗静, 等. 147例常见结缔组织病相关间质性肺病的临床特征及转归分析[J]. 西安交通大学学报(医学版), 2019, 40(4): 598-603.
[5] 杨叶梦. IPAF与CTD-ILD临床特点[D]: [硕士学位论文]. 南昌: 南昌大学, 2017.
[6] Travis, W.D., Costabel, U., Hansell, D.M., et al. (2013) An Official American Thoracic Society/European Respiratory Society Statement: Update of the International Multidisciplinary Classification of the Idiopathic Interstitial Pneumonias. American Journal of Respiratory and Critical Care Medicine, 188, 733-748. [Google Scholar] [CrossRef] 
[7] Cottin, V. and Brown, K.K. (2019) Interstitial Lung Disease Associated with Systemic Sclerosis (SSc-ILD). Respiratory Research, 20, Article No. 13. [Google Scholar] [CrossRef] [PubMed]
[8] Manfredi, A., Cassone, G., Luppi, F., et al. (2021) Rheumatoid Arthritis Related Interstitial Lung Disease. Expert Review of Clinical Immunology, 17, 485-497. [Google Scholar] [CrossRef] 
[9] 敖知, 朱旭友, 郭述良, 等. 结缔组织疾病相关性间质性肺病的病理特征分析: 基于经支气管冷冻肺活检[J]. 重庆医学, 2021, 50(6): 973-976, 981.
[10] 逯明蕾. 结缔组织病相关肺间质病变的临床与基础研究[D]: [硕士学位论文]. 广州: 南方医科大学, 2011.
[11] 熊晓静. CTD-ILD患者血清学指标的临床意义[D]: [硕士学位论文]. 乌鲁木齐: 新疆医科大学, 2019.
[12] Lud-wicka-Bradley, A., Silver, R.M. and Bogatkevich, G.S. (2011) Coagulation and Autoimmunity in Scleroderma Interstitial Lung Disease. Seminars in Arthritis and Rheumatism, 41, 212-222. [Google Scholar] [CrossRef] [PubMed]
[13] Zhao, L., Su, K., Liu, T., et al. (2021) Myositis-Specific Au-toanti Bodies in Adults with Idiopathic Inflammatory Myopathy: Correlations with Diagnosis and Disease Activity. Clin-ical Rheumatology, 40, 1009-1016.
[14] Long, K. and Danoff, S.K. (2019) Interstitial Lung Disease in Polymyositis and Dermatomyositis. Clinics in Chest Medicine, 40, 561-572. [Google Scholar] [CrossRef] [PubMed]
[15] Kelly, C.A., Saravanan, V., et al. (2014) Rheumatoid Arthritis-Related Interstitial Lung Disease: Associations, Prognostic Fac-tors and Physiological and Radiological Characteristics—A Large Multicentre UK Study. Rheumatology, 53, 1676-1682. [Google Scholar] [CrossRef] [PubMed]
[16] 苗珍珍, 殷松楼, 殷寒秋. 人血清抗MCV-Ab与类风湿关节炎合并间质性肺病的关系[J]. 河北医药, 2018, 40(14): 2095-2098.
[17] Luppi, F., Sebastiani, M., Silva, M., Sverzellati, N., Cavazza, A., Salvarani, C. and Manfredi, A. (2020) Interstitial Lung Disease in Sjögren’s Syndrome: A Clinical Review. Clinical and Experimental Rheumatology, 126, 291-300.
[18] Erre, G.L., Sebastiani, M., Manfredi, A., Gerratana, E., Atzeni, F., Passiu, G. and Mangoni, A.A. (2020) Antifibrotic Drugs in Connective Tissue Disease-Related Interstitial Lung Disease (CTD-ILD): From Mechanistic Insights to Therapeutic Applications. Drugs in Context, 9, Arti-cle ID: 2020-8-6. [Google Scholar] [CrossRef] [PubMed]
[19] Yoo, H., Hino, T., Han, J., Franks, T.J., Im, Y., Hata-bu, H., Chung, M.P and Lee, K.S. (2020) Connective Tissue Disease-Related Interstitial Lung Disease (CTD-ILD) and Interstitial Lung Abnormality (ILA): Evolving Concept of CT Findings, Pathology and Management. European Journal of Radiology Open, 8, Article ID: 100311. [Google Scholar] [CrossRef] [PubMed]
[20] Wells, A.U. (2021) New Insights into the Treatment of CTD-ILD. Nature Reviews Rheumatology, 17, 79-80. [Google Scholar] [CrossRef] [PubMed]
[21] Kowal-Bielecka, O., Fransen, J., Avouac, J., et al. (2017) Update of EULAR Recommendations for the Treatment of Systemic Sclerosis. Annals of the Rheumatic Diseases, 76, 1327-1339. [Google Scholar] [CrossRef] [PubMed]
[22] Jee, A.S. and Corte, T.J. (2019) Current and Emerging Drug Therapies for Connective Tissue Disease-Interstitial Lung Disease (CTD-ILD). Drugs, 79, 1511-1528. [Google Scholar] [CrossRef] [PubMed]

为你推荐