儿童荨麻疹患者血清IL-4、IL-9的临床意义的研究

Study on the Clinical Significance of Serum IL-4 and IL-9 in Children with Urticaria

摘要: 目的：探讨急性荨麻疹患儿外周血血清中IL-4、IL-9水平情况及其在疾病中的作用。方法：回顾性分析2020年8月至2022年8月急性荨麻疹患儿43例，采用双抗体ELISA法检测患者外周血清中IL-4、IL-9和IFN-γ水平，并与正常对照组进行比较。结果：1) 观察组与对照组相比，IL-4 (45.32 ± 7.43) ng/L、IL-9 (134.45 ± 27.24) ng/L水平均有显著升高，差异均有统计学意义(P < 0.05)，但两组间IFN-γ (54.19 ± 7.21) ng/L和健康对照组差异无统计学意义(P > 0.05)。2) 血清IL-4、IL-9水平变化与急性荨麻疹患儿病情严重程度密切相关(r = 0.41, P < 0.05) (r = 0.271, P < 0.05)。结论：IL-4、IL-9在儿童急性荨麻疹的发病中发挥了重要作用。

Abstract: Objective: To investigate the levels of IL-4, IL-9 and IFN-γ in serum of the patients with acute urti-caria (AU), and to explore their roles in the disease. Methods: Each 43 children diagnosed as AU from August 2020 to August 2022 were retrospectively analyzed. The levels of IL-4, IL-9 and IFN-γ in the peripheral serum of patients were determined by double antibody ELISA and compared with normal controls. Results: 1) Compared with control group, the concentration of IL-4 (45.32 ± 7.43) ng/L, IL-9 (134.45 ± 27.24) ng/L in observation group was increased, the difference was statisti-cally significant (P < 0.05), but the serum levels of IFN-γ (54.19 ± 7.21) ng/L was not significant difference between in the normal control groups. 2) The serum concentrations of IL-4, IL-19 in AU patients were all positively correlated with three different severity degrees of their illness (r = 0.41, P < 0.05) (r = 0.271, P < 0.05). Conclusion: IL-4 and IL-9 play an important role in the pathogenesis of AU in children.