腺苷激活A1与A2A受体诱导睡眠的研究进展
Advances in Sleep Induction by Adenosine Activation of A1 and A2A Receptors
DOI: 10.12677/ACM.2023.132291, PDF,    科研立项经费支持
作者: 蒋单栋：杭州医学院临床医学院，浙江 杭州；俞 盈, 么春艳*：杭州医学院食品科学与工程学院，浙江 杭州；任思齐：杭州医学院药学院，浙江 杭州；邹 莹：浙江中医药大学附属第二医院，浙江 杭州
关键词: 腺苷；睡眠；咖啡因；腺苷A1受体；腺苷A2A受体；Adenosine； Sleep； Caffeine； Adenosine A1 Receptor； Adenosine A2A Receptor
摘要: 睡眠–觉醒是一个涉及多系统、多中枢的生理过程，这一变化过程可通过脑内多种神经递质和内源性睡眠物质共同作用而实现。作为一种核苷，腺苷是目前发现的最强的内源性促眠物质之一，激活A1和A2A受体诱导睡眠，其中又以A2A受体占主导作用，A1受体在不同脑区表现出区域特异性。作为中枢腺苷受体拮抗剂，咖啡因通过纹状体伏隔核壳区的A2A受体发挥觉醒效能。为更好地理解腺苷对睡眠的调节机制以及为新型失眠药的研发提供思路，本文对腺苷的代谢和睡眠稳态、A1、A2A受体对睡眠调节作用的差异、咖啡因与A2A受体的关系等内容进行了系统描述。
Abstract: Sleep-wakefulness is a multi-system and multi-center physiological process, which can be realized through the interaction of various neurotransmitters and endogenous sleep substances in the brain. Adenosine, a nucleoside with the strongest sleep-inducing effect, has been found involving in the accumulation of sleep stress and inducing sleep through activation of A2A and A1 receptors, with A2A receptor playing a dominant role and A1 receptor showing regional specificities in different brain regions. As a central receptor antagonist of adenosine, caffeine exerts its awakening effect through A2A receptor in the nucleus accumbens region of the striatum. In order to better under-stand the regulatory mechanism of adenosine on sleep and provide ideas for the product develop-ment of new insomnia drugs, this paper systematically described the metabolism and sleep homeo-stasis of adenosine, the difference of A1 and A2A receptors on sleep regulation, and the relationship between caffeine and A2A receptors.
文章引用：蒋单栋, 俞盈, 任思齐, 邹莹, 么春艳. 腺苷激活A1与A2A受体诱导睡眠的研究进展[J]. 临床医学进展, 2023, 13(2): 2083-2092. https://doi.org/10.12677/ACM.2023.132291

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