血清SUR1水平与高血压脑出血后脑水肿严重程度及预后的关系

The Relationship between Serum SUR1 Level and the Severity and Prognosis of Cerebral Edema after Hypertensive Intracerebral Hemorrhage

摘要: 目的：探讨血清磺酰脲受体-1水平与脑出血后脑水肿严重程度及预后的相关性。方法：选取2021年1月至2022年4月于重庆医科大学附属第二医院神经外科或重症医学科就诊的自发性脑出血患者131例作为研究，选取同期该院健康体检者131例为对照组，利用酶联免疫吸附试验测定研究组入院时、入院1 d、3 d、5 d、7 d及对照组体检时血清磺酰脲受体-1水平；比较研究组入院不同时间段和对照组，以及与影像学所示的脑水肿体积的相关性；Logistic回归分析影响高血压脑出血患者预后不良的危险因素。结果：研究者血清SUR1水平显著高于健康对照组(P < 0.01)。研究组入院时、入院后1 d、3 d、5 d、7 d血清SUR1水平呈单峰线性分布，峰值出现在第3天，较影像学上脑水肿高峰提前出现，且均高于对照组(P < 0.01)。Logistic回归分析中，血清SUR1浓度能独立预测患者不良预后。结论：高血压脑出血患者血清SUR1水平与患者脑水肿严重程度高度相关，并与脑出血后的不良预后独立相关，表明血清SUR1水平可能是脑出血的预后标志物。

Abstract: Objective: To investigate the correlation between the level of serum sulfonylurea receptor-1 (SUR1) and the severity and prognosis of cerebral edema after intracerebral hemorrhage. Methods: 131 patients with spontaneous intracerebral hemorrhage who were treated in the Department of Neu-rosurgery or Intensive Medicine of the Second Affiliated Hospital of Chongqing Medical University from January 2021 to April 2022 were selected as the study group, and 131 healthy persons in the same period were selected as the control group. The serum sulfonylurea receptor-1 level was measured by enzyme-linked immunosorbent assay at the time of admission, 1, 3, 5, 7 days after admission, and at the time of physical examination in the study group; Comparing serum SUR 1 concentrations between the control and study groups and the correlation between serum SUR 1 concentrations with the volume of brain edema as shown by imaging; Logistic regression analysis was used to analyze the risk factors of poor prognosis in patients with hypertensive intracerebral hemorrhage. Results: The serum SUR1 level of the researchers was significantly higher than that of the healthy control group (P < 0.01). The serum SUR1 level in the study group showed a single peak linear distribution at the time of admission and on the 1st, 3rd, 5th and 7th day after admission, and the peak appeared on the 3rd day, which was earlier than the peak of brain edema on imaging, and was higher than that in the control group (P < 0.01). In logistic regression analysis, serum SUR1 concentration can independently predict the poor prognosis of patients. Conclusion: The serum SUR1 level in patients with hypertensive intracerebral hemorrhage is highly correlated with the severity of cerebral edema, and is independent of the adverse prognosis after intracerebral hem-orrhage, indicating that the serum SUR1 level may be a prognostic marker of intracerebral hemor-rhage.