光动力疗法联合PD-1抑制剂治疗支气管肿瘤1例并文献复习
A Case of Elderly Refractory Giant Stone Bile Duct Stent Combined with Pharmacological Treatment and Review of Literature
摘要: 最近的实验研究发现，光动力疗法(PDT)联合程序性死亡受体1 (PD-1)/程序性细胞死亡配体1 (PD-L1)抑制剂可以有效抑制原位肿瘤生长，防止肿瘤复发和转移，已成为一种新的治疗方案。然而，临床数据仍然有限。在此，我们介绍了一例晚期肺癌患者在PDT联合PD-1抑制剂治疗后获得完全缓解(CR)，并在14个月的随访中没有复发和转移的病例报告。通过这种方式，我们回顾了PDT联合PD-1/PD-L1抑制剂的文献，并对实验和临床数据以及可能的分子机制进行了概述。
Abstract: Recent experimental studies have found that photodynamic therapy (PDT) combined with pro-grammed death receptor 1 (PD-1)/programmed cell death-Ligand 1 (PD-L1) inhibitors can effec-tively inhibit in situ tumor growth and prevent tumor recurrence and metastasis, and has emerged as a new therapeutic option. However, clinical data is still limited. Here, we present a case report of a patient with advanced lung cancer who achieved complete remission (CR) after PDT combined with a PD-1 inhibitor and was free of recurrence and metastasis during 14 months of follow-up. In this way, we review the literature on PDT in combination with PD-1/PD-L1 inhibitors and provide an overview of the experimental and clinical data and possible molecular mechanisms.
文章引用：王靖宇, 曹艺巍, 韩伟忠, 林存智. 光动力疗法联合PD-1抑制剂治疗支气管肿瘤1例并文献复习[J]. 临床医学进展, 2023, 13(2): 2136-2141. https://doi.org/10.12677/ACM.2023.132299

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