牙龈卟啉单胞菌致病性及药物治疗的研究进展
Research Progress in Pathogenicity and Drug Therapy of Porphyromonas gingivalis
DOI: 10.12677/ACM.2023.132302, PDF,   
作者: 高 婧*, 杨晓莉#:青海大学临床医学院,青海 西宁
关键词: 牙龈卟啉单胞菌致病性药物治疗Porphyromonas gingivalis Pathogenic Drug Therapy
摘要: 牙龈卟啉单胞菌(Porphyromonas gingivalis, Pg)是一种革兰氏阴性口腔厌氧菌,这种厌氧菌具有致病性,表达多种毒力因子,如脂多糖、肽聚糖和牙龈蛋白酶等。Pg是慢性牙周炎的主要病原体,有研究发现其与阿尔兹海默病、类风湿性关节炎、食管癌、结肠癌等有一定关联。因此了解Pg的致病机制及其治疗有一定的必要性。本文现综述Pg的致病性及其药物治疗如下。
Abstract: Porphyromonas gingivalis (Pg) is a Gram-negative oral anaerobic bacterium, which is pathogenic and expresses a variety of virulence factors, such as lipopolysaccharide, peptidoglycan and gingi-valis. Pg is the main pathogen of chronic periodontitis, which has been found to be associated with Alzheimer’s disease, rheumatoid arthritis, esophageal cancer, colon cancer and so on. Therefore, it is necessary to understand the pathogenesis and treatment of Pg. This article reviews the patho-genesis and drug treatment of Pg as follows.
文章引用:高婧, 杨晓莉. 牙龈卟啉单胞菌致病性及药物治疗的研究进展[J]. 临床医学进展, 2023, 13(2): 2155-2159. https://doi.org/10.12677/ACM.2023.132302

参考文献

[1] Ge, Y., Zhang, R., Feng, Y., et al. (2021) Mbd2 Deficiency Alleviates Retinal Cell Apoptosisvia the miR-345-5p/Atf1 Axis in High Glucoseinjury and Streptozotocin-Induced Diabetic Mice. Molecular Therapy—Nucleic Acids, 26, 1201- 1214. [Google Scholar] [CrossRef] [PubMed]
[2] Pan, H., Wang, D. and Zhang, F. (2020) In Vitro Antimi-crobial Effect of Curcumin-Based Photodynamic Therapy on Porphyromonas gingivalis and Aggregatibacter actinomy-cetemcomitans. Photodiagnosis and Photodynamic Therapy, 32, 102055. [Google Scholar] [CrossRef] [PubMed]
[3] Kolenbrander, P.E., Palmer, R.J., Rickard, A.H., et al. (2006) Bacterial Interactions and Successions during Plaque Development. Periodontology 2000, 42, 47-79. [Google Scholar] [CrossRef] [PubMed]
[4] Daalderop, L.A., Wieland, B.V., Tomsin, K., et al. (2018) Periodontal Disease and Pregnancy Outcomes: Overview of Systematic Reviews. JDR Clinical and Translational Re-search, 3, 10-27. [Google Scholar] [CrossRef] [PubMed]
[5] Singhrao, S.K., Harding, A., Poole, S., et al. (2015) Porphyromonas gingivalis Periodontal Infection and Its Putative Links with Alzheimer’s Disease. Mediators of Inflammation, 2015, Article ID: 137357. [Google Scholar] [CrossRef] [PubMed]
[6] Taubman, M.A. and Kawai, T. (2001) Involvement of T-Lymphocytes in Periodontal Disease and in Direct and Indirect Induction of Bone Resorption. Critical Reviews in Oral Biology & Medi-cine, 12, 125-135. [Google Scholar] [CrossRef] [PubMed]
[7] Guo, Y., Nguyen, K.A. and Potempa, J. (2000) Dichotomy of Gingipains Action as Virulence Factors: From Cleaving Substrates with the Precision of a Surgeon’s Knife to a Meat Chopper-Like Brutal Degradation of Proteins. Periodontology, 54, 15-44. [Google Scholar] [CrossRef] [PubMed]
[8] Olsen, I. and Potempa, J. (2014) Strategies for the Inhibi-tion of Gingipains for the Potential Treatment of Periodontitis and Associated Systemic Diseases. Journal of Oral Micro-biology, 6. [Google Scholar] [CrossRef] [PubMed]
[9] Yamatake, K., Maeda, M., Kadowaki, T., et al. (2007) Role for Gingipains in Porphyromonas gingivalis Traffic to Phagolysosomes and Survival In Human Aortic Endothelial Cells. Infection and Immunity, 75, 2090-2100. [Google Scholar] [CrossRef
[10] Dominy, S.S., Lynch, C., Ermini, F., et al. (2019) Porphyromonas gin-givalis in Alzheimer’s Disease Brains: Evidence for Disease Causation and Treatment with Small-Molecule Inhibitors. Science Advances, 5, u3333.
[11] Bostanci, N. and Belibasakis, G.N. (2012) Porphyromonas gingivalis: An Invasive and Evasive Opportunistic Oral Pathogen. FEMS Microbiology Letters, 333, 1-9. [Google Scholar] [CrossRef] [PubMed]
[12] Hajishengallis, G., Liang, S., Payne, M.A., et al. (2011) Low-Abundance Biofilm Species Orchestrates Inflammatory Periodontal Disease through the Commensal Microbiota and Complement. Cell Host & Microbe, 10, 497-506. [Google Scholar] [CrossRef] [PubMed]
[13] Yoshimura, F., Murakami, Y., Nishikawa, K., et al. (2009) Sur-face Components of Porphyromonas gingivalis. Journal of Periodontal Research, 44, 1-12. [Google Scholar] [CrossRef] [PubMed]
[14] Amano, A. (2003) Molecular Interaction of Porphyromo-nas gingivalis with Host Cells: Implication for the Microbial Pathogenesis of Periodontal Disease. Journal of Periodon-tology, 74, 90-96. [Google Scholar] [CrossRef] [PubMed]
[15] Wang, P.L. and Ohura, K. (2002) Porphyromonas gingivalis Lipopolysaccharide Signaling in Gingival Fibroblasts-CD14 and Toll-Like Receptors. Critical Reviews in Oral Biology & Medicine, 13, 132-142. [Google Scholar] [CrossRef] [PubMed]
[16] Bainbridge, B.W. and Darveau, R.P. (2001) Porphyromonas gingivalis Lipopolysaccharide: An Unusual Pattern Recognition Receptor Ligand for the Innate Host Defense System. Acta Odontologica Scandinavica, 59, 131-138. [Google Scholar] [CrossRef] [PubMed]
[17] Olczak, T., Simpson, W., Liu, X., et al. (2005) Iron and Heme Utilization in Porphyromonas gingivalis. FEMS Microbiology Reviews, 29, 119-144. [Google Scholar] [CrossRef] [PubMed]
[18] Desvarieux, M., Demmer, R.T., Rundek, T., et al. (2005) Perio-dontal Microbiota and Carotid Intima-Media Thickness: the Oral Infections and Vascular Disease Epidemiology Study (INVEST). Circulation, 111, 576-582. [Google Scholar] [CrossRef
[19] Soares, G.M., Teles, F., Starr, J.R., et al. (2015) Ef-fects of Azithromycin, Metronidazole, Amoxicillin, and Metronidazole plus Amoxicillin on an in Vitro Polymicrobial Subgingival Biofilm Model. Antimicrobial Agents and Chemotherapy, 59, 2791-2798. [Google Scholar] [CrossRef
[20] Hajishengallis, G., Darveau, R.P. and Curtis, M.A. (2012) The Key-stone-Pathogen Hypothesis. Nature Reviews Microbiology, 10, 717-725. [Google Scholar] [CrossRef] [PubMed]
[21] Anjana, R.R., Parikh, P.V., Mahla, J.K., et al. (2021) Comparative Eval-uation of Isoflurane and Sevoflurane in Avian Patients. Veterinary World, 14, 1067-1073. [Google Scholar] [CrossRef] [PubMed]
[22] Pogue, J.M., Kaye, K.S., Cohen, D.A., et al. (2015) Ap-propriate Antimicrobial Therapy in the Era of Multidrug-Resistant Human Pathogens. Clinical Microbiology and Infec-tion, 21, 302-312. [Google Scholar] [CrossRef] [PubMed]
[23] Ben, L.A., Howell, A. and Grenier, D. (2020) Highbush Blueberry Proanthocyanidins Alleviate Porphyromonas gingivalis-Induced Deleterious Effects on Oral Mu-cosal Cells. Anaerobe, 65, Article ID: 102266. [Google Scholar] [CrossRef] [PubMed]
[24] Ben, L.A., LeBel, G. and Grenier, D. (2018) Dual Action of Highbush Blueberry Proanthocyanidins on Aggregatibacter actinomycetemcomitans and the Host Inflammatory Re-sponse. BMC Complementary and Alternative Medicine, 18, 10. [Google Scholar] [CrossRef] [PubMed]
[25] Hajishengallis, G. and Lamont, R.J. (2014) Breaking Bad: Manip-ulation of the Host Response by Porphyromonas gingivalis. European Journal of Immunology, 44, 328-338. [Google Scholar] [CrossRef] [PubMed]
[26] Tian, J., Geiss, C., Zarse, K., et al. (2021) Green Tea Catechins EGCG and ECG Enhance the Fitness and Lifespan of Caenorhabditis elegans by Complex I Inhibition. Aging (Albany NY), 13, 22629-22648. [Google Scholar] [CrossRef] [PubMed]
[27] Fernandes, F., Cukier, A., Camelier, A.A., et al. (2017) Recommenda-tions for the Pharmacological Treatment of COPD: Questions and Answers. Jornal Brasileiro de Pneumologia, 43, 290-301. [Google Scholar] [CrossRef] [PubMed]
[28] Moghadamtousi, S.Z., Kadir, H.A., Hassandarvish, P., et al. (2014) A Review on Antibacterial, Antiviral, and Antifungal Activity of Curcumin. BioMed Research International, 2014, Article ID: 186864. [Google Scholar] [CrossRef] [PubMed]
[29] Ben, L.A. and Grenier, D. (2017) Black Tea Theaflavins Attenuate Por-phyromonas gingivalis Virulence Properties, Modulate Gingival Keratinocyte Tight Junction Integrity and Exert An-ti-Inflammatory Activity. Journal of Periodontal Research, 52, 458-470. [Google Scholar] [CrossRef] [PubMed]
[30] Sforcin, J.M. (2016) Biological Properties and Therapeutic Applications of Propolis. Phytotherapy Research, 30, 894-905. [Google Scholar] [CrossRef] [PubMed]
[31] Huang, S., Zhang, C.P., Wang, K., et al. (2014) Recent Advances in the Chemical Composition of Propolis. Molecules, 19, 19610-19632. [Google Scholar] [CrossRef] [PubMed]