高危型HPVE6/E7mRNA检测在宫颈病变筛查过程中的临床应用价值

Clinical Value of High-Risk HPVE6/E7mRNA Test in Screening for Cervical Lesions

摘要: 宫颈癌是女性生殖系统常见的妇科肿瘤之一，近年发病率呈逐渐上升，严重威胁女性健康。高危型人乳头瘤病毒(HPV)持续性感染与宫颈癌的发生密切相关，但自HPV感染发展为宫颈癌需要多年，因此宫颈癌早期筛查尤为重要。近年来HR-HPVE6/E7mRNA检测是一种新开发的宫颈癌筛查工具，其检测程序主要包括靶标俘获、转录介导型扩增、杂交保护测定(HPA)检测扩增产物，能够检测HPV感染并同时预测宫颈病变的变化，目前全球部分地区已经使用，为无创操作，有良好的安全性。HPVE6/E7mRNA检测对宫颈癌筛查、提高女性生活质量具有重要意义，随着HPVE6/E7mRNA检测的推广及应用，将有更多女性远离宫颈癌困扰。

Abstract: Cervical cancer is one of the common gynecological tumors in the female reproductive system. In recent years, the incidence has gradually increased, posing a serious threat to women’s health. Per-sistent infection of high-risk human papillomavirus (HPV) is closely related to the occurrence of cervical cancer, but it takes many years for HPV infection to develop into cervical cancer, so early screening of cervical cancer is particularly important. In recent years, HR-HPVE6/E7mRNA detec-tion is a newly developed cervical cancer screening tool, its detection program mainly includes tar-get capture, transcription-mediated amplification, hybridization protection determination (HPA) detection amplification products, can detect HPV infection and predict the change of cervical lesions at the same time, some parts of the world have been used, for non-invasive operation, have good safety. HPVE6/E7mRNA testing is of great significance for cervical cancer screening and the im-provement of women’s quality of life. With the promotion and application of HPVE6/E7mRNA test-ing, more women will stay away from cervical cancer problems.