肝癌血供特点及影响
Characteristics and Influence of Blood Supply of Liver Cancer
摘要: 肝脏是人体中重要的器官,肝脏疾病,影响人们健康状况,恶性肿瘤更是使其雪上加霜。肝脏自身血供特点,也决定了肝脏疾病的特殊性,肝脏疾病过程中,病理生理学的改变必然引起肝脏血流动力学的改变。探讨肝癌血流动力学的改变,从不同的角度为肝癌的诊断、治疗提供新的临床思路。
Abstract: The liver is an important organ in the human body, liver disease affects people’s health, malignant tumors make it worse. The characteristics of the blood supply of the liver itself also determine the particularity of the liver disease. In the process of the liver disease, changes in the Pathophysiology will inevitably lead to changes in the Hemodynamics of the liver to explore the changes of liver can-cer Hemodynamics, and to provide new clinical ideas for the diagnosis and treatment of liver cancer from different angles.
文章引用:叶艳霞. 肝癌血供特点及影响[J]. 临床医学进展, 2023, 13(2): 2200-2205. https://doi.org/10.12677/ACM.2023.132309

参考文献

[1] Ferlay, J., Colombet, M., Soerjomataram, I., et al. (2019) Estimating the Global Cancer Incidence and Mortality in 2018: GLOBOCAN Sources and Methods. International Journal of Cancer, 144, 1941-1953. [Google Scholar] [CrossRef] [PubMed]
[2] Bray, F., Ferlay, J., Soerjomataram, I., et al. (2018) Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 68, 394-424. [Google Scholar] [CrossRef] [PubMed]
[3] Shiraha, H., Iwamuro, M. and Okada, H. (2020) Hepatic Stellate Cells in Liver Tumor. Advances in Experimental Medicine and Biology, 1234, 43-56. [Google Scholar] [CrossRef] [PubMed]
[4] Bertuccio, P., Turati, F., Carioli, G., et al. (2017) Global Trends and Predictions in Hepatocellular Carcinoma Mortality. Journal of Hepatology, 67, 302-309. [Google Scholar] [CrossRef] [PubMed]
[5] McGuire, S. (2016) World Cancer Report 2014. Geneva, Switzer-land: World Health Organization, International Agency for Research on Cancer, WHO Press, 2015. Advances in Nutri-tion, 7, 418-419. [Google Scholar] [CrossRef] [PubMed]
[6] El-Serag, H.B. (2011) Hepatocellular Carcinoma. The New England Journal of Medicine, 365, 1118-1127. [Google Scholar] [CrossRef
[7] Zheng, R.S., et al. (2022) Cancer Incidence and Mortality in China 2016. Journal of the National Cancer Center, 2, 1-9. [Google Scholar] [CrossRef] [PubMed]
[8] Baglieri, J., Brenner, D.A. and Kisseleva, T. (2019) The Role of Fibrosis and Liver-Associated Fibroblasts in the Pathogenesis of Hepatocellular Carcinoma. International Journal of Molecular Sciences, 20, pii: E1723. [Google Scholar] [CrossRef] [PubMed]
[9] Tang, Z.Y., Qin, L.X., Wang, X.M., et al. (1998) Alterations of Onco-genes, Tumor Suppressor Genes and Growth Factors in Hepatocellular Carcinoma: With Relation to Tumor Size and In-vasiveness. Chinese Medical Journal, 111, 313-318.
[10] Murakami, S. (2001) Hepatitis B Virus X Protein: A Multi-functional Viral Regulator. Journal of Gastroenterology, 36, 651-660. [Google Scholar] [CrossRef] [PubMed]
[11] Inoue, H. and Seitz, H.K. (2001) Viruses and Alcohol in the Patho-genesis of Primary Hepatic Carcinoma. European Journal of Cancer Prevention, 10, 107-110. [Google Scholar] [CrossRef] [PubMed]
[12] Wang, Y.M., Ng, W.C. and Lo, S.K. (1999) Detection of pre-S/S Gene Mutants in Chronic Hepatitis B Carriers with Concurrent Hepatitis B Surface Antibody and Hepatitis B Surface Antigen. Journal of Gastroenterology, 34, 600-606. [Google Scholar] [CrossRef] [PubMed]
[13] Seitz, H.K. (2000) Alcohol and Retinoid Metabolism. Gut, 47, 748-750. [Google Scholar] [CrossRef] [PubMed]
[14] Jackson, P.E., Groopman, J.D. (1999) Aflatoxin and Liver Cancer. Bailliere’s Clinical Gastroenterology, 13, 545-555. [Google Scholar] [CrossRef] [PubMed]
[15] Wogan, G.N. (1992) Aflatoxins as Risk Factors for Hepatocellular Carcinoma in Humans. Cancer Research, 52, 2114s-2118s.
[16] Fodor, D., Jung, I., Turdean, S., et al. (2019) Angio-genesis of Hepatocellular Carcinoma: An Immunohistochemistry Study. World Journal of Hepatology, 11, 294-304. [Google Scholar] [CrossRef] [PubMed]
[17] Morse, M.A., Sun, W., Kim, R., et al. (2019) The Role of Angiogene-sis in Hepatocellular Carcinoma. Clinical Cancer Research, 25, 912-920. [Google Scholar] [CrossRef
[18] Robinson, P. (2008) Hepatocellular Carcinoma: Develop-ment and Early Detection. Cancer Imaging, 8, S128-S131. [Google Scholar] [CrossRef] [PubMed]
[19] Saitoh, S., Ikeda, K., Koida, I., et al. (1995) Serial Hemody-namic Measurements in Well Differentiated Hepatocellular Carcinomas. Hepatology, 21, 1530-1534. [Google Scholar] [CrossRef] [PubMed]
[20] Nakashima, Y., Nakashima, O., Hsia, C.C., et al. (1999) Vasculari-zation of Small Hepatocellular Carcinomas: Correlation with Differentiation. Liver, 19, 12-18. [Google Scholar] [CrossRef] [PubMed]
[21] Muto, J., Shirabe, K., Sugimachi, K., et al. (2015) Re-view of Angiogenesis in Hepatocellularcarcinoma. Hepatology Research, 45, 1-9. [Google Scholar] [CrossRef] [PubMed]
[22] Carr, B.I. (2004) Hepatocellular Carcinoma: Current Management and Fu-ture Trends. Gastroenterology, 127, S218-S224. [Google Scholar] [CrossRef] [PubMed]
[23] Zhu, A.X., Du-da, D.G., Sahani, D.V., et al. (2011) HCC and Angiogenesis: Possible Targets and Future Directions. Nature Reviews Clinical Oncology, 8, 292-301. [Google Scholar] [CrossRef] [PubMed]
[24] Heil, M., Eitenmuller, I., Schmitz-Rixen, T., et al. (2006) Arteriogenesis versus Angiogenesis: Similarities and Differences. Journal of Cellular and Molecular Medicine, 10, 45-55. [Google Scholar] [CrossRef] [PubMed]
[25] Matsui, O., Kadoya, M., Kameyama, T., et al. (1991) Benign and Malignant Nodules in Cirrhotic Livers. Distinction Based on Blood Supply. Radiology, 178, 493-497. [Google Scholar] [CrossRef] [PubMed]
[26] Kudo, M., Tomita, S., Kashida, H., et al. (1991) Tumor Hemodynamics in Hepatic Nodules Associated with Liver Cirrhosis. Relationship between Cancer Progression and Tumor Hemodynamic Change. Japanese Journal of Gastroenterology, 88, 1554-1565.
[27] Kudo, M., Tomita, S., Tochio, H., et al. (1992) Hemodynamic Characteristics of Early Stage Hepatocellular Carcinoma. In Vivo Evaluation with Vascular Imagings. Acta Hepatologica Japonica, 33, 283-291. [Google Scholar] [CrossRef
[28] Kudo, M. (1999) Imaging Diagnosis of Hepatocellular Carcinoma and Premalignant/Borderline Lesions. Seminars in Liver Disease, 19, 297-309. [Google Scholar] [CrossRef] [PubMed]
[29] Ueda, K., Matsui, O., Kawamori, Y., et al. (1998) Hypervascular Hepatocellular Carcinoma: Evaluation of Hemodynamics with Dynamic CT during Hepatic Arteriography. Radiology, 206, 161-165. [Google Scholar] [CrossRef] [PubMed]
[30] Yamanaka, N., Okamoto, E., Fujihara, S., et al. (1992) Do the Tumor Cells of Hepatocellular Carcinomas Dislodge into the Portal Venous Stream during Hepatic Resection? Cancer, 70, 2263-2267. [Google Scholar] [CrossRef
[31] Tanaka, T., Yamanaka, N., Oriyama, T., et al. (1997) Factors Regulating Tumor Pressure in Hepatocellular Carcinoma and Implica-tions for Tumor Spread. Hepatology, 26, 283-287. [Google Scholar] [CrossRef] [PubMed]
[32] Fang, K.J., Wang, L.F., Huang, H.Y., et al. (2020) Construction of Nucleolin-Targeted Lipid Nanobubbles and Contrast-Enhanced Ultra-sound Molecular Imaging in Triple-Negative Breast Cancer. Nature, 37, 145. [Google Scholar] [CrossRef] [PubMed]
[33] Hayashi, M., Matsui, O., Ueda, K., et al. (2002) Progression to Hypervascular Hepatocellular Carcinoma: Correlation with Intranodular Blood Supply Evaluated with CT during Intraar-terial Injection of Contrast Material. Radiology, 225, 143-149. [Google Scholar] [CrossRef] [PubMed]
[34] Hsieh, M.C., Hsu, H.T., Hsiao, P.C., et al. (2014) Role of VEGF-C Gene Polymorphisms in Susceptibility to Hepatocellular Carcinoma and Its Pathological Development. Journal of Clinical Laboratory Analysis, 28, 237-244. [Google Scholar] [CrossRef] [PubMed]
[35] Miles, K.A. (1999) Tumour Angiogenesis and Its Relation to Contrast En-hancement on Computed Tomography: A Review. European Journal of Radiology, 30, 198-205. [Google Scholar] [CrossRef
[36] 聂东雷, 陈亚晗, 陆玉敏. 肝细胞癌CT表现、病理分级与CD34表达的关系研究[J]. 右江医学, 2016, 44(6): 639-642.
[37] Kojiro, M., Nakashima, T. and Mori, T (1988) Pathomorphologic Characteristics of 102 Cases of Thorotrast-Related Hepatocellular Carcinoma, Cholangiocarcinoma, and Hepatic Angiosarcoma. Cancer, 62, 1153-1162. [Google Scholar] [CrossRef
[38] Sakamoto, M., Hirohashi, S. and Shimosato, Y. (1991) Early Stage of Multistep Hepatocarcinogenesis: Adenomatous Hyperplasia and Early Hepatocellular Carcinoma. Human Pathology, 22, 172-178. [Google Scholar] [CrossRef
[39] Takayama, T., Makuuchi, M., Hirohashi, S., et al. (1990) Ma-lignant Transformation of Adenomatous Hyperplasia to Hepatocellular Carcinoma. The Lancet, 336, 1150-1153. [Google Scholar] [CrossRef
[40] Kim, S.R., Hayashi, Y., Kudo, M., et al. (2000) A Case of Hepatocellular Carcinoma Transforming from Adenomatous Hyperplasia in Three Years with the Background of Non-B Non-C, Non-TTV Chronic Persistent Hepatitis. Intervirology, 43, 13-15. [Google Scholar] [CrossRef] [PubMed]
[41] Kim, S.R., Hayashi, Y., Kudo, M., et al. (2000) Hepatocellular Carcinoma Transforming from Dysplastic Nodule with Background of Non-B Non-C Chronic Persistent Hepatitis. Journal of Hepatology, 33, 857-858. [Google Scholar] [CrossRef
[42] Berzigotti, A., Dapporto, S., Angeloni, L., et al. (2004) Postprandial Splanchnic Haemodynamic Changes in Patients with Liver Cirrhosis and Patent Paraumbilical Vein. Euro-pean Journal of Gastroenterology & Hepatology, 16, 1339-1345. [Google Scholar] [CrossRef] [PubMed]
[43] Kutami, R., Nakashima, Y., Nakashima, O., et al. (2000) Pathomorphologic Study on the Mechanism of Fatty Change in Small Hepatocellular Carcinoma of Humans. Journal of Hepatology, 33, 282-289. [Google Scholar] [CrossRef
[44] 黄大庆, 曾波, 牟忠亮, 等. 多层螺旋CT灌注成像下肝癌结节血流动力学的改变[J]. 实用癌症杂志, 2014(10): 1304-1306.
[45] Wei, Y., Yang, Q., Zhang, Y., et al. (2017) Plumbagin Restrains Hepatocellular Carcinoma Angiogenesis by Suppressing the Migration and Invasion of Tu-mor-Derived Vascular Endothelial Cells. Oncotarget, 8, 15230-15241. [Google Scholar] [CrossRef] [PubMed]
[46] Xiang, X., You, X.M. and Li, L.Q. (2018) Expression of HSP 90AA1/HSPA8 in Hepatocellular Carcinoma Patients with Depression. OncoTargets and Therapy, 22, 3013-3023. [Google Scholar] [CrossRef
[47] 邵佳娴. 术前彩色多普勒超声血流参数对分化型甲状腺癌颈部淋巴结转移的诊断价值[J]. 中国药物与临床, 2019, 19(12): 1991-1992.
[48] 韩建梅, 葛玲, 任冰, 等. 卵巢癌患者经阴道彩色多普勒超声血流参数与血管新生及肿瘤恶性程度的关系[J]. 临床超声医学杂志, 2018, 20(5): 314-317.
[49] 汪荣, 洪云, 严稳开. 超声血流参数在预测甲状腺乳头状癌患者颈部淋巴结转移中的价值分析[J]. 生物医学工程与临床, 2020, 24(6): 693-697.
[50] 周艳珂, 李潜, 田婧, 等. 超声血流参数及高频超声诊断甲状腺癌颈部淋巴结转移的临床价值[J]. 医学影像学杂志, 2020, 30(10): 1945-1947.
[51] Cabibbo, G., Maida, M., Genco, C., et al. (2013) Survival of Patients with Hepatocellular Carcinoma (HCC) Treated by Percutaneous Radio-Frequency Ablation (RFA) Is Affected by Complete Radiological Response. PLOS ONE, 8, e70016. [Google Scholar] [CrossRef] [PubMed]
[52] Taylor, K.J., Ramos, I., Morse, S.S., et al. (1987) Focal Liver Masses: Differential Diagnosis with Pulsed Doppler US. Radiology, 164, 643-647. [Google Scholar] [CrossRef] [PubMed]
[53] 梁丽, 宋妮. 肝脏超声血流参数对肝癌术后复发的预测价值[J]. 实用癌症杂志, 2019, 34(8): 1286-1289.