长链非编码RNA-HOTAIR对恶性肿瘤放疗敏感性的研究
Study on the Sensitivity of Long Non-Coding RNA-HOTAIR to Radiotherapy for Malignant Tumors
DOI: 10.12677/ACM.2023.132335, PDF,   
作者: 肖雪玲, 赵化荣*：新疆医科大学第一附属医院肿瘤中心，新疆 乌鲁木齐
关键词: 长链非编码RNA；HOTAIR；放疗敏感性；Long Non-Coding RNA； HOTAIR； Radiotherapy Sensitivity
摘要: 放射抵抗及肿瘤细胞对放射线不敏感使得放射治疗在恶性肿瘤治疗中的有效性大大降低。已有研究表明在肺癌、乳腺癌、宫颈癌、胰腺癌等恶性肿瘤中存在不同程度水平的HOTAIR表达水平升高，进一步研究发现HOTAIR在肿瘤生长、增殖、转移、侵袭等过程中也扮演着重要角色，同时也影响恶性肿瘤放疗的敏感性，对放射线敏感性差及放疗抵抗的恶性肿瘤组织及细胞中表现出HOTAIR表达升高的趋势，诸多研究证明恶性肿瘤中HOTAIR表达升高与放射抵抗相关，因此明确部分患者对放射治疗抵抗的分子机制尤为重要，增加肿瘤的放疗敏感性，对提高患者的治疗效果，具有重要的临床意义。
Abstract: Radiation resistance and insensitivity of tumor cells to radiation greatly reduce the effectiveness of radiotherapy in the treatment of malignant tumors. Existing studies have shown that HOTAIR ex-pression level increases at different levels in malignant tumors such as lung cancer, breast cancer, cervical cancer and pancreatic cancer. Further studies have found that HOTAIR also plays an im-portant role in tumor growth, proliferation, metastasis, invasion and other processes, and also af-fects the sensitivity of radiotherapy for malignant tumors. Malignant tumor tissues and cells with poor sensitivity to radiation and resistance to radiotherapy show a trend of increased HOTAIR ex-pression, and many studies have proved that the increased HOTAIR expression in malignant tu-mors is related to radiation resistance. Therefore, it is particularly important to identify the molec-ular mechanism of some patients’ resistance to radiotherapy, so as to increase the radiotherapy sensitivity of tumors and improve the therapeutic effect of patients. It has important clinical signif-icance.
文章引用：肖雪玲, 赵化荣. 长链非编码RNA-HOTAIR对恶性肿瘤放疗敏感性的研究[J]. 临床医学进展, 2023, 13(2): 2386-2391. https://doi.org/10.12677/ACM.2023.132335

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