PI3K/Akt信号通路与糖尿病性骨质疏松相关性研究进展
Research Progress on the Relationship between PI3K/Akt Signaling Pathway and Diabetic Osteoporosis
DOI: 10.12677/ACM.2023.132343, PDF,    科研立项经费支持
作者: 朱 玲：大理大学临床医学院，云南 大理；朱恩江：弥勒市中医医院骨伤二科，云南 弥勒；孙曙光*：大理大学第一附属医院内分泌科，云南 大理
关键词: PI3K/Akt信号通路；糖尿病性骨质疏松；相关性；PI3K/Akt Signaling Pathway； Diabetic Osteoporosis； Pertinence
摘要: 糖尿病(diabetes mellitus, DM)是一种高发的代谢性疾病，可引发骨骼、血管、神经等多系统并发症，其中骨质疏松症(osteoporosis, OP)是其常见并发症之一。糖尿病性骨质疏松(diabetic osteoporosis, DOP)主要表现为糖尿病患者出现骨代谢异常、骨脆性增加，易发生骨折，其骨代谢紊乱的机制十分复杂。最新的研究表明，磷脂酰肌醇三激酶/蛋白激酶B (PI3K/Akt)通路可参与骨代谢的调节，对调控骨髓间质干细胞、成骨细胞和破骨细胞等细胞的生长、增殖、分化、凋亡和衰老具有重要意义，成为当前的研究热点。结合目前国内外学者对PI3K/Akt通路与糖尿病性骨质疏松的相关机制进行的研究，本文将对PI3K/Akt信号通路与糖尿病性骨质疏松的相关性进行综述，为进一步研究抗糖尿病性骨质疏松药物提供更多思路及重要靶点。
Abstract: Diabetes mellitus (DM) is a metabolic disease with high incidence, which can cause multi-system complications such as bone, vascular, nerve and so on. Osteoporosis (OP) is one of its common com-plications. Diabetic osteoporosis (DOP) is mainly characterized by abnormal bone metabolism, in-creased bone fragility and fracture in diabetic patients. The mechanism of bone metabolism disor-der is very complex. Recent studies have shown that the phosphatidylinositol trikinase/protein ki-nase B (PI3K/Akt) pathway can participate in the regulation of bone metabolism, which is of great significance in regulating the growth, proliferation, differentiation, apoptosis and aging of bone marrow mesenchymal stem cells, osteoblasts and osteoclasts, and has become a current research hotspot. Combined with the current domestic and foreign scholars’ research on the mechanism of PI3K/Akt signaling pathway and diabetic osteoporosis, this article will review the correlation be-tween PI3K/Akt signaling pathway and diabetic osteoporosis, and provide more ideas and im-portant targets for further research on anti-diabetic osteoporosis drugs.
文章引用：朱玲, 朱恩江, 孙曙光. PI3K/Akt信号通路与糖尿病性骨质疏松相关性研究进展[J]. 临床医学进展, 2023, 13(2): 2437-2443. https://doi.org/10.12677/ACM.2023.132343

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