慢性自发性荨麻疹发病机制研究进展
Research Progress in Pathogenesis of Chron-ic Spontaneous Urticaria
DOI: 10.12677/ACM.2023.132354, PDF,   
作者: 王灵灵, 朱雅琳：新疆医科大学第一附属医院皮肤科，新疆 乌鲁木齐
关键词: 慢性自发性荨麻疹；发病机制；研究进展；Chronic Spontaneous Urticaria； Pathogenesis； Research Progress
摘要: 慢性自发性荨麻疹(Chronic spontaneous urticaria, CSU)是以瘙痒性风团伴或不伴血管性水肿为特点的过敏性疾病，持续时间 > 6周并且没有明确的病因，是慢性荨麻疹最常见类型，其发病机制复杂，目前尚未证实CSU的确切机制，研究发现自身免疫、凝血异常、维生素D、慢性感染、心理精神及遗传机制在CSU的发病中起到一定作用。本文就CSU的发病机制展开综述，为慢性自发性荨麻疹的机制研究及临床治疗提供理论依据。
Abstract: Chronic spontaneous urticaria is an allergic disease characterized by pruritic wheal with or without Angioedema. It is the most common type of chronic urticaria with a duration of >6 weeks and no definite etiology, the pathogenesis of CSU is complicated, and the exact mechanism of CSU has not been confirmed. It was found that autoimmunity, abnormal coagulation, vitamin D, chronic infection, psychology and genetic mechanism play a certain role in the pathogenesis of CSU. This article re-views the pathogenesis of CSU, and provides theoretical basis for the mechanism research and clin-ical treatment of chronic spontaneous urticaria.
文章引用：王灵灵, 朱雅琳. 慢性自发性荨麻疹发病机制研究进展[J]. 临床医学进展, 2023, 13(2): 2511-2515. https://doi.org/10.12677/ACM.2023.132354

参考文献

[1] 中华医学会皮肤性病学分会荨麻疹研究中心. 中国荨麻疹诊疗指南(2018版) [J]. 中华皮肤科杂志, 2019, 52(1): 5.
[2] The EAACI/GA2LEN/EDF/WAO (2013) Guideline for the Definition, Classification, Diagnosis, and Manage-ment of Urticaria: The 2013 Revision and Update.
[3] Zawar, V., Pawar, M. and Kumavat, S. (2018) Malassezia Infec-tion Associated with Chronic Spontaneous Urticaria without Angioedema: A Report on Five Cases. Acta Dermatovener-ologica Alpina, Pannonica et Adriatica, 27, 65-69. [Google Scholar] [CrossRef] 
[4] Kolkhir, P., Metz, M., Altrichter, S., et al. (2017) Comorbidity of Chronic Spontaneous Urticaria and Autoimmune Thyroid Diseases: A Systematic Review. Allergy, 72, 1440-1460. [Google Scholar] [CrossRef] [PubMed]
[5] Sauer, M., Scheffel, J., Frischbutter, S., et al. (2021) Lower IgA Levels in Chronic Spontaneous Urticaria Are Associated with Lower IgE Levels and Autoimmunity. Frontiers in Immunology, 12, Article ID: 657211. [Google Scholar] [CrossRef] [PubMed]
[6] Jang, J.H., Moon, J., Yang, E.M., et al. (2022) Detection of Se-rum IgG Autoantibodies to FcεRIα by ELISA in Patients with Chronic Spontaneous Urticaria. PLOS ONE, 17, e0273415. [Google Scholar] [CrossRef] [PubMed]
[7] Altrichter, S., Chuamanochan, M., Knoth, H., et al. (2019) Real-Life Treatment of Cholinergic Urticaria with Omalizumab. Journal of Allergy and Clinical Immunology, 143, 788-791.e8. [Google Scholar] [CrossRef] [PubMed]
[8] Asero, R. (2013) D-Dimer: A Biomarker for Antihis-tamine-Resistant Chronic Urticaria. Journal of Allergy and Clinical Immunology, 132, 983-986. [Google Scholar] [CrossRef] [PubMed]
[9] Asero, R., Tedeschi, A., Coppola, R., et al. (2007) Activation of the Tissue Factor Pathway of Blood Coagulation in Patients with Chronic Urticaria. Journal of Allergy and Clinical Immu-nology, 119, 705-710. [Google Scholar] [CrossRef] [PubMed]
[10] Saito, R., Yanase, Y., Kamegashira, A., et al. (2020) Increase of Tissue Factor Expression on the Surface of Peripheral Monocytes of Patients with Chronic Spontaneous Urticaria. Aller-gy, 75, 971-974. [Google Scholar] [CrossRef] [PubMed]
[11] Parslew, R., Pryce, D., Ashworth, J., et al. (2000) Warfarin Treatment of Chronic Idiopathic Urticaria and Angio-Oedema. Clinical & Experimental Allergy, 30, 1161-1165. [Google Scholar] [CrossRef] [PubMed]
[12] Obtułowicz, A., Migacz-Gruszka, K., Pirowska, M., et al. (2020) Participation of the Coagulation System and Fibrinolysis as Well as Selected Biomarkers in Pathogenesis of Chronic Urticaria with Various Activity Degree. Postepy Dermatologii I Alergologii, 37, 608-612. [Google Scholar] [CrossRef] [PubMed]
[13] Dabas, G., Thakur, V., Bishnoi, A., et al. (2021) Causal Relationship between D-Dimers and Disease Status in Chronic Spontaneous Urticaria and Adjuvant Effect of Oral Tranexamic Acid. Indian Dermatology Online Journal, 12, 726-730. [Google Scholar] [CrossRef] 
[14] Ariaee, N., Zarei, S., Mohamadi, M., et al. (2017) Amelioration of Patients with Chronic Spontaneous Urticaria in Treatment with Vitamin D Supplement. Clinical and Molecular Allergy, 15, 22. [Google Scholar] [CrossRef] [PubMed]
[15] 宿斌, 熊志飞, 赵炳, 等. 慢性自发性荨麻疹患者血清维生素D, 脱氢表雄酮硫酸酯水平与Th1/Th2细胞因子及免疫球蛋白的关系分析[J]. 国际检验医学杂志, 2020, 41(4): 435-439.
[16] Ma, Y., Xiang, Z., Yao, X., et al. (2020) Associations between Vitamin D Receptor Gene Polymor-phisms and Chronic Spontaneous Urticaria in Chinese Han Population. Postepy Dermatologii I Alergologii, 37, 250-254. [Google Scholar] [CrossRef] [PubMed]
[17] Grzanka, A., Machura, E., Mazur, B., et al. (2014) Relationship be-tween Vitamin D Status and the Inflammatory State in Patients with Chronic Spontaneous Urticaria. Journal of Inflam-mation (London), 11, 2. [Google Scholar] [CrossRef] [PubMed]
[18] Yip, K.H., Kolesnikoff, N., Yu, C., et al. (2014) Mechanisms of Vitamin D3 Metabolite Repression of IgE-Dependent Mast Cell Activation. Journal of Allergy and Clinical Immunology, 133, 1356-1364. [Google Scholar] [CrossRef] [PubMed]
[19] Yoshimasu, T. and Furukawa, F. (2014) Eradication Therapy for Urticaria with High Titers of Anti-H. pylori IgG Antibody. Allergology International, 63, 37-40. [Google Scholar] [CrossRef] 
[20] Hizal, M., Tüzün, B., Wolf, R., et al. (2000) The Relationship between Helicobacter pylori IgG Antibody and Autologous Serum Test in Chronic Urticaria. International Journal of Dermatology, 39, 443-445. [Google Scholar] [CrossRef] [PubMed]
[21] Fakhar, M., Ghaffari, J., Dabbaghzadeh, A., et al. (2021) Prevalence of Intestinal Parasites among Patients with Chronic Urticaria in Northern Iran. Infectious Disorders—Drug Targets Disorders, 21, 130-133. [Google Scholar] [CrossRef] [PubMed]
[22] 吴登艳, 杜茂涛, 谭燃景. 慢性自发性荨麻疹患者的血清抗幽门螺杆菌抗体研究[J]. 西南大学学报(自然科学版), 2021, 43(9): 30-37.
[23] Ćesić, D., Lugović-Mihić, L., Ferček, I., et al. (2021) Salivary Microbiota Is Significantly Less Diverse in Patients with Chronic Spontaneous Urti-caria Compared to Healthy Controls: Preliminary Results. Life (Basel), 11, 1329. [Google Scholar] [CrossRef] [PubMed]
[24] Wang, D., Guo, S., He, H., et al. (2020) Gut Microbiome and Serum Metabolome Analyses Identify Unsaturated Fatty Acids and Butanoate Metabolism Induced by Gut Microbiota in Pa-tients with Chronic Spontaneous Urticaria. Frontiers in Cellular and Infection Microbiology, 10, 24. [Google Scholar] [CrossRef] [PubMed]
[25] Wang, X., Yi, W., He, L., et al. (2021) Abnormalities in Gut Mi-crobiota and Metabolism in Patients with Chronic Spontaneous Urticaria. Frontiers in Immunology, 12, Article ID: 691304. [Google Scholar] [CrossRef] [PubMed]
[26] Bozo, Ö., Demirtepe-Saygılı, D., Güneş, S., et al. (2018) Does Problem Focused Coping Buffer the Effects of Trait Anxiety on Depressive Symptoms of Chronic Urticaria Pa-tients? The Journal of General Psychology, 145, 64-78. [Google Scholar] [CrossRef] [PubMed]
[27] Engin, B., Uguz, F., Yilmaz, E., et al. (2008) The Levels of Depression, Anxiety and Quality of Life in Patients with Chronic Idiopathic Urticaria. The Journal of the European Academy of Dermatology and Venereology, 22, 36-40.
[28] Tat, T.S. (2019) Higher Levels of Depression and Anxiety in Patients with Chronic Urticaria. Medical Science Monitor, 25, 115-120. [Google Scholar] [CrossRef] 
[29] Hergüner, S., Kiliç, G., Karakoç, S., et al. (2011) Levels of Depression, Anxiety and Behavioural Problems and Frequency of Psychiatric Disorders in Children with Chronic Idiopathic Urticaria. British Journal of Dermatology, 164, 1342-1347. [Google Scholar] [CrossRef] [PubMed]
[30] Ozkan, M., Oflaz, S.B., Kocaman, N., et al. (2007) Psychiatric Morbidity and Quality of Life in Patients with Chronic Idiopathic Urticaria. Annals of Allergy, Asthma & Immunology, 99, 29-33. [Google Scholar] [CrossRef] 
[31] Bozek, A., Krajewska, J., Filipowska, B., et al. (2010) HLA Status in Patients with Chronic Spontaneous Urticaria. International Archives of Allergy and Immunology, 153, 419-423. [Google Scholar] [CrossRef] [PubMed]
[32] Piconi, S., Trabattoni, D., Iemoli, E., et al. (2002) Immune Profiles of Pa-tients with Chronic Idiopathic Urticaria. International Archives of Allergy and Immunology, 128, 59-66. [Google Scholar] [CrossRef] [PubMed]
[33] Asero, R. (2002) Chronic Idiopathic Urticaria: A Family Study. Annals of Allergy, Asthma & Immunology, 89, 195-196. [Google Scholar] [CrossRef] 

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