二肽基肽酶-4 (DPP4)促进脂肪细胞氧化应激及炎症反应的分子机制研究
Molecular Mechanism of Dipeptidyl Peptidase-4 (DPP4) Promoting Oxidative Stress and Inflammatory Response of Adipocytes
DOI: 10.12677/ACM.2023.132357, PDF,   
作者: 依力汗·依明：新疆医科大学研究生学院，新疆 乌鲁木齐 ；艾克拜尔·艾力：新疆医科大学研究生学院，新疆 乌鲁木齐；新疆维吾尔自治区人民医院微创，疝和腹壁外科，新疆 乌鲁木齐 ；买买提·依斯热依力：新疆医科大学研究生学院，新疆 乌鲁木齐；新疆维吾尔自治区胃食管反流病及减重代谢外科临床研究中心，新疆 乌鲁木齐；艾合麦提·喀斯木：新疆维吾尔自治区胃食管反流病及减重代谢外科临床研究中心，新疆 乌鲁木齐
关键词: 二肽基肽酶-4；氧化应激；脂肪细胞炎症反应；肥胖症；Dipeptidyl Peptidase-4； Oxidative Stress； Adipocyte Inflammatory Reaction； Obesity
摘要: 肥胖症(Obesity)是世界范围内一个日益严重的健康问题。作为代谢综合征的标志，肥胖症常与慢性疾病的发展有关，包括2型糖尿病和脂代谢紊乱。脂肪组织是肥胖相关代谢紊乱进展的基础，其内分泌作用在致病环节中起关键作用：通过产生各种称为脂肪因子或脂肪细胞因子的因子，如瘦素、脂联素、单核细胞趋化蛋白-1 (MCP-1)、肿瘤坏死因子-α (TNF)和白细胞介素-6 (IL-6)。目前肥胖症的具体发病机制尚不明确，但脂肪细胞炎症学说和脂肪细胞氧化应激学已被广泛接受。本综述旨在对二肽基肽酶-4 (DPP4)与脂肪细胞氧化应激及炎症反应中的机制进行行总结叙述。
Abstract: Obesity is an increasingly serious health problem all over the world. As a sign of metabolic syn-drome, obesity is often associated with the development of chronic diseases, including type 2 dia-betes and lipid metabolism disorders. Adipose tissue is the basis for the progress of obesity related metabolic disorders, and its endocrine role plays a key role in the pathogenesis: through the pro-duction of various factors called adipokines or adipocytokines, such as leptin, adiponectin, mono-cyte chemoattractant protein-1 (MCP-1) and tumor death factor-α (TNF) and interleukin-6 (IL-6). At present, the specific pathogenesis of obesity is not clear, but the theory of adipocyte inflammation and adipocyte oxidative stress has been widely accepted. This review aims to summarize the mechanism of dipeptidyl peptidase-4 (DPP4) and adipocyte oxidative stress and inflammatory re-sponse.
文章引用：依力汗·依明, 艾克拜尔·艾力, 买买提·依斯热依力, 艾合麦提·喀斯木. 二肽基肽酶-4 (DPP4)促进脂肪细胞氧化应激及炎症反应的分子机制研究[J]. 临床医学进展, 2023, 13(2): 2529-2935. https://doi.org/10.12677/ACM.2023.132357

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