PLK1在恶性肿瘤中的研究进展
Recent Research Progress of PLK1 in Malignant Tumors
DOI: 10.12677/ACM.2023.132358, PDF,    国家自然科学基金支持
作者: 郭 涛*, 张黎明:济宁医学院临床医学院,山东 济宁;王丽娜:济宁医学院附属医院,医学研究中心,山东 济宁;王少强#:济宁医学院附属医院,胸外科,山东 济宁
关键词: PLK1肿瘤癌症预后PLK1 Tumor Cancer Prognosis
摘要: 保罗样激酶1 (Polo-like kinase1, PLK1)属于Polo样激酶家族,是一类广泛存在于真核细胞中的丝氨酸/苏氨酸激酶,在调节细胞的有丝分裂和DNA复制中发挥重要作用。大量研究表明,PLK1在多种恶性肿瘤细胞中高表达,并与肿瘤的分期以及不良预后相关。下调PLK1的表达可抑制恶性肿瘤的进展、提高肿瘤细胞放化疗敏感性。由此可见,PLK1可能是恶性肿瘤的潜在治疗靶点。本文就PLK1的结构和功能以及在肺癌、乳腺癌等恶性肿瘤中的作用作以综述。
Abstract: PLK1 plays an important role in regulating cellular functions such as mitosis and DNA replication. Numerous studies have shown that PLK1 expression is increased in a variety of malignant tumor cells and is closely related to tumor stage and poor prognosis. Inhibiting PLK1 expression can affect the cell cycle and DNA replication to inhibit the development of malignant tumor cells and improve the sensitivity to radiotherapy. Therefore, PLK1 might be an important target for the treatment of malignant tumors. In this article, we review the structure and function of PLK1, and the close rela-tionship between PLK1 and malignant tumors such as lung cancer, breast cancer, etc.
文章引用:郭涛, 王丽娜, 张黎明, 王少强. PLK1在恶性肿瘤中的研究进展[J]. 临床医学进展, 2023, 13(2): 2536-2542. https://doi.org/10.12677/ACM.2023.132358

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