IL-6与结直肠癌治疗及预后相关研究进展
Research Progress on the Relationship between IL-6 and the Treatment and Prognosis of Colorectal Cancer
摘要: 白细胞介素6 (IL-6)作为一种细胞因子,在炎症、免疫、肿瘤发生发展等多个方面发挥重要作用。结直肠癌是全球常见的恶性肿瘤,其发病及死亡均居世界前位。结直肠癌患者血清IL-6水平显著升高,IL-6通过多种途径调控结直肠癌的发生发展,且与患者不良预后相关。传统抗肿瘤治疗以及治疗过程中不良反应及耐药的发生同样与IL-6的息息相关。靶向IL-6或其受体在结直肠癌治疗方面具有极大潜力。本文将对IL-6与结直肠癌治疗及预后相关研究进展进行综述,为寻找新的结直肠癌预后标志物及治疗手段提供新的思路。
Abstract: Interleukin 6 (IL-6), as a cytokine, plays an important role in inflammation, immunity, tumorigene-sis and development. Colorectal cancer is a common malignant tumor in the world, and its morbidi-ty and mortality rank first in the world. Serum IL-6 levels in patients with colorectal cancer are sig-nificantly increased, and IL-6 regulates the occurrence and development of colorectal cancer through various ways, and is associated with poor prognosis of patients. Traditional antitumor therapy and the occurrence of adverse reactions and drug resistance during treatment are also closely related to IL-6. Targeting IL-6 or its receptors has great potential in the treatment of colo-rectal cancer. This article will review the research progress related to IL-6 and the treatment and prognosis of colorectal cancer, and provide new ideas for the search for new prognostic markers and treatment methods of colorectal cancer.
文章引用:边晓倩, 孙丽斌, 丁怡心, 王赫, 齐卫卫. IL-6与结直肠癌治疗及预后相关研究进展[J]. 临床医学进展, 2023, 13(2): 2581-2587. https://doi.org/10.12677/ACM.2023.132365

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