植物营养素对阿尔茨海默病的作用机制研究

Mechanism of Action of Phytonutrients on Alzheimer’s Disease

摘要: 阿尔茨海默病(Alzheimer’s Disease, AD)作为严重危害人类生命健康的疾病之一，面对日益加重的人口老龄化现象，全球罹患AD的患者只多不少。对于AD的研究人类仍处在预防和缓解的阶段，目前正在向着治疗AD的方向上发展钻研。饮食是人类日常生活中的一部分，可以作为预防和缓解AD病情的第一道保障，并非保健药物才可以发挥此类作用。一些有益物质可以从食物中获取，这些有益物质通过消除、抑制β淀粉样蛋白(Aβ protein, Aβ)的积累和tau的过度磷酸化，阻碍老年斑块的形成和进一步发展，增强线粒体的活性，激发相关酶的功能，来保护神经元及脑组织不受损伤，从这些方面上一定限度的对AD的病情起到了预防和缓解效果。但是由于AD的致病机制复杂，对其成因尚未有一个确切的定论。因此人们在饮食方面上对预防AD的进程愈发的重视起来，并取得了不少显著的成果，从中人们发现日常饮食在许多方面上对AD的进程有着抑制作用，进而降低罹患AD的风险。

Abstract: Dementia, also known as Alzheimer’s disease (AD), is one of the diseases that seriously endanger human life and health. Only a few patients suffer from AD worldwide in the face of the increasing aging of the population. The research on it is still in the stage of prevention and remission and research is developing towards the direction of treating AD. Diet as a part of human daily life is the first guarantee to prevent and relieve AD disease not only health care drugs can play such a role. Some beneficial substances can be obtained from food. These beneficial substances can prevent the formation and further development of aged plaques by eliminating and inhibiting the accumulation of Aβ protein (Aβ) and the over-phosphorylation of tau enhance the activity of mitochondria stimulate the function of related enzymes and protect neurons and brain tissue from damage. From these aspects to a certain extent, the disease of AD has played a preventive and alleviating effect. However, due to the complex pathogenesis of AD, there has not been an exact conclusion on its cause. Therefore, people pay more and more attention to preventing the process of AD in terms of diet and a lot of remarkable results have been achieved from which people find that daily diet has an inhibitory effect on the process of AD in many aspects, so as to reduce the risk of AD.