深度水解蛋白配方奶粉联合糠酸莫米松乳膏治疗牛奶蛋白过敏性婴儿湿疹的临床研究

Clinical Study of Extensively Hydrolyzedformula Combined with Mometasone Furoate Cream in the Treatment of Infantile Eczema with Cow Milk Protein Allergy

摘要: 目的：深度水解蛋白配方奶粉联合糠酸莫米松乳膏治疗婴儿湿疹的临床效果研究。方法：回顾性收集2019年8月至2022年12月年龄1~3个月就诊于青岛大学附属医院儿童保健科门诊治疗的59例牛奶蛋白过敏性湿疹患儿和68例非牛奶蛋白过敏母乳喂养湿疹患儿。按照临床治疗方案不同分为观察组(n = 59)和对照组(n = 68)。观察组给予深度水解蛋白配方奶粉和母亲回避牛奶及奶制品联合糠酸莫米松乳膏治疗，对照组给予继续母乳喂养联合糠酸莫米松乳膏治疗。两组均给予糠酸莫米松乳膏外涂患处，2次/日，疗程为14天或治愈为止(但不超过28天)。1月治疗结束后比较两组疗效。结果：观察组皮损和瘙痒缓解时间均短于对照组，复发率低于对照组，差异有统计学意义(P < 0.05)；观察组总有效率高于对照组，差异具有统计学意义(P < 0.05)。结论：采取深度水解蛋白配方粉和母亲回避牛奶及奶制品喂养进行早期干预，可进一步提高治疗效果，促进病情快速恢复，避免复发，安全性高，复发率低，值得临床推广。

Abstract: Objective: To investigate the clinical efficacy of extensively hydrolyzedformula combined with mo-metasone furoate cream in the treatment of infantile eczema. Methods: 59 formula children with cow’s milk protein allergic eczema and 68 breastfeeding children with non-milk protein allergy ec-zema were collected in the outpatient clinic of the Department of Child Healthcare, the Affiliated Hospital of Qingdao University from August 2019 to December 2022. According to different clinical treatment, they were divided into observation group (n = 59) and control group (n = 68). The ob-servation group was treated with extensively hydrolyzed formula combined with mometasone fu-roate cream. At the same time, mother’s diet should avoid cow’s milk and milk products. The con-trol group was treated with mometasone furoate cream, going on with their breastfeeding without controlling of mother’s diet. Mometasone furoate cream was applied to the skin lesions twice a day in both groups for 14 days or until cure (but not more than 28 days). The efficacy of the two groups was compared after the end of treatment at one month. Results: The remission time of skin lesions and itching in the observation group was shorter than that in the control group, and the recurrence rate was lower than that in the control group, with a statistically significant difference (P < 0.05), and the total effective rate in the observation group was higher than that in the control group (P < 0.05). Conclusion: Early intervention with extensively hydrolyzed formula and mother’s avoidance of milk and dairy products can further improve the treatment effect, promote rapid recovery of the disease, avoid recurrence, with high safety and low recurrence rate, which is worthy of clinical pro-motion.