D-二聚体水平对放化疗结直肠癌患者的预后价值：Meta分析
Prognostic Value of D-Dimer Level in Patients with Colorectal Cancer Treated with Chemoradiotherapy: A Meta-Analysis
DOI: 10.12677/ACM.2023.132394, PDF,   
作者: 吴刚杰, 雷 春：暨南大学第一临床医学院，广东 广州；龚晓兵*：暨南大学附属第一医院全科医学科，广东 广州
关键词: D-二聚体；结直肠癌；放化疗；预后；D-Dimer； Colorectal Cancer； Chemoradiotherapy； Prognosis
摘要: 目的：探究放化疗前结直肠癌患者的血浆D-二聚体水平与其生存预后之间的关系。方法：检索The Cochrane Library、PubMed、Embase、Web of Science、中国知网(CNKI)、万方数据知识服务平台、维普中文期刊数据库(VIP)，纳入所有符合纳入标准的研究，检索时限从建库起至2022年12月。由两名研究人员分别对检索出的文献按纳入与排除标准筛选文献、提取资料，并采用Revman 5.4软件进行Meta分析。结果：最终纳入10篇文献，包括1465名患者进行分析。Meta分析结果显示D-二聚体水平高的放化疗结直肠癌患者相比于D-二聚体水平正常的放化疗结直肠癌患者有较差的OS (HR: 1.62, 95% CI: 1.44, 1.83; P < 0.00001)，差异具有统计学意义。结论：高血浆D-二聚体水平可能是放化疗的结直肠癌患者评估预后的预测因子。
Abstract: Objective: To explore the relationship between plasma D-dimer level and survival prognosis in pa-tients with colorectal cancer before chemoradiotherapy. Methods: The Cochrane Library, PubMed, Embase, Web of Science, China National Knowledge Network (CNKI), Wanfang Data Knowledge Ser-vice Platform and VIP Chinese journal Database were searched, and all studies meeting the inclu-sion criteria were included. The search period is from the establishment of the database to Decem-ber 2022. Two researchers screened literatures and extracted data according to inclusion and ex-clusion criteria respectively, and meta-analysis was performed using Revman 5.4 software. Results: Finally, 10 literatures including 1465 patients were included for analysis. Meta-analysis showed that patients with high D-dimer level had worse OS than those with normal D-dimer level (HR: 1.62, 95% CI: 1.44, 1.83; P < 0.00001), the difference was statistically significant. Conclusion: High plas-ma D-dimer levels may be a predictor of prognosis in patients with colorectal cancer assessed by chemoradiotherapy.
文章引用：吴刚杰, 雷春, 龚晓兵. D-二聚体水平对放化疗结直肠癌患者的预后价值：Meta分析[J]. 临床医学进展, 2023, 13(2): 2794-2801. https://doi.org/10.12677/ACM.2023.132394

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