阿尔茨海默病治疗进展
Progress in the Treatment of Alzheimer’s Disease
DOI: 10.12677/ACM.2023.133433, PDF,   
作者: 朱 亭, 韦玉栋:长治医学院研究生院,山西 长治;尚进林*:长治医学院和平附属医院神经内科,山西 长治
关键词: 阿尔兹海默病治疗药物治疗非药物治疗Alzheimer’s Disease Treatment Pharmaceutical Treatment Non-Pharmaceutical Treatment
摘要: 阿尔茨海默病(Alzheimer’s Disease, AD)是一种以认知障碍、人格和行为改变为特征的进行性神经退行性疾病,到目前为止,没有发现可以治愈AD或者有效逆转疾病发生发展的药物,药物治疗、非药物治疗等仅能够缓解症状和减慢疾病进程。本文围绕AD的药物治疗与非药物治疗进展进行综述。
Abstract: Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by cognitive impairment, personality and behavioral changes. So far, no drugs have been found that can cure AD or effectively reverse the occurrence and development of the disease. Drug treatment, non-drug treatment, etc. can only alleviate symptoms and slow down the disease process. This article reviews the progress of drug treatment and non-drug treatment of AD.
文章引用:朱亭, 韦玉栋, 尚进林. 阿尔茨海默病治疗进展[J]. 临床医学进展, 2023, 13(3): 3049-3055. https://doi.org/10.12677/ACM.2023.133433

参考文献

[1] Lu, J., Zhang, C., Lv, J., et al. (2021) Antiallergic Drug Desloratadine as a Selective Antagonist of 5HT2A Receptor Ameliorates Pathology of Alzheimer’s Disease Model Mice by Improving Microglial Dysfunction. Aging Cell, 20, e13286. [Google Scholar] [CrossRef] [PubMed]
[2] Srivastava, S., Ahmad, R. and Khare, S.K. (2021) Alzheimer’s Disease and Its Treatment by Different Approaches: A Review. European Journal of Medicinal Chemistry, 216, Article ID: 113320. [Google Scholar] [CrossRef] [PubMed]
[3] Chu, L.W. (2012) Alzheimer’s Disease: Early Diagnosis and Treatment. Hong Kong Medical Journal, 18, 228-237.
[4] Birks, J. (2006) Cholinesterase Inhibitors for Alzheimer’s Disease. The Cochrane Database of Systematic Reviews, No. 1, CD005593. [Google Scholar] [CrossRef
[5] Hansen, R.A., Gartlehner, G., Webb, A.P., et al. (2008) Effi-cacy and Safety of Donepezil, Galantamine, and Rivastigmine for the Treatment of Alzheimer’s Disease: A Systematic Review and Meta-Analysis. Clinical Interventions in Aging, 3, 211-225.
[6] Qaseem, A., Snow, V., Cross, J.T., et al. (2008) Current Pharmacologic Treatment of Dementia: A Clinical Practice Guideline from the American College of Physicians and the American Academy of Family Physicians. Annals of Internal Medicine, 148, 370-378. [Google Scholar] [CrossRef] [PubMed]
[7] Stazi, M. and Wirths, O. (2021) Chronic Memantine Treatment Ameliorates Behavioral Deficits, Neuron Loss, and Impaired Neurogenesis in a Model of Alz-heimer’s Disease. Molecular Neurobiology, 58, 204-216. [Google Scholar] [CrossRef] [PubMed]
[8] Irshad, M. and Chaudhuri, P.S. (2002) Oxidant-Antioxidant System: Role and Significance in Human Body. Indian Journal of Experimental Biology, 40, 1233-1239.
[9] Nair, S., Rocha-Ferreira, E., Fleiss, B., et al. (2021) Neuroprotection Offered by Mesenchymal Stem Cells in Perinatal brain Injury: Role of Mitochondria, Inflammation, and Reactive Oxygen Species. Journal of Neurochemistry, 158, 59-73. [Google Scholar] [CrossRef] [PubMed]
[10] Jiang, Q. (2014) Natural Forms of Vitamin E: Metabolism, Antioxidant and Anti-Inflammatory Activities and the Role in Disease Prevention and Therapy. Free Radical Biology & Medicine, 72, 76-90. [Google Scholar] [CrossRef] [PubMed]
[11] La Fata, G., Weber, P. and Mohajeri, M.H. (2014) Ef-fects of Vitamin E on Cognitive Performance during Ageing and in Alzheimer’s Disease. Nutrients, 6, 5453-5472. [Google Scholar] [CrossRef] [PubMed]
[12] Mangialasche, F., Solomon, A., Kåreholt, I., et al. (2013) Serum Levels of Vitamin E Forms and Risk of Cognitive Impairment in a Finnish Cohort of Older Adults. Experimental Gerontology, 48, 1428-1435. [Google Scholar] [CrossRef] [PubMed]
[13] Luchsinger, J.A., et al. (2003) Antioxidant Vitamin Intake and Risk of Alzheimer Disease. Archives of Neurology, 60, 203-208.
https://jamanetwork.com/journals/jamaneurology/fullarticle/783735
[14] Lloret, A., Badía, M.-C., Mora, N.J., et al. (2009) Vitamin E Paradox in Alzheimer’s Disease: It Does Not Prevent Loss of Cognition and May Even Be Detrimental. Journal of Alzheimer’s Disease, 17, 143-149. [Google Scholar] [CrossRef
[15] Singh, S.K., Srivastav, S., Castellani, R.J., et al. (2019) Neuroprotective and Antioxidant Effect of Ginkgo Biloba Extract against AD and Other Neurological Disorders. Neurotherapeutics, 16, 666-674. [Google Scholar] [CrossRef] [PubMed]
[16] Verma, S., Ranawat, P., Sharma, N., et al. (2019) Ginkgo Biloba Attenuates Aluminum Lactate-Induced Neurotoxicity in Reproductive Senescent Female Rats: Behavioral, Biochemical, and Histopathological Study. Environmental Science and Pollution Research, 26, 27148-27167. [Google Scholar] [CrossRef] [PubMed]
[17] Mazza, M., Capuano, A., Bria, P., et al. (2006) Ginkgo Biloba and Donepezil: A Comparison in the Treatment of Alzheimer’s Dementia in a Randomized Placebo-Controlled Dou-ble-Blind Study. European Journal of Neurology, 13, 981-985. [Google Scholar] [CrossRef] [PubMed]
[18] Canevelli, M., Adali, N., Kelaiditi, E., et al. (2014) Effects of Gingko Biloba Supplementation in Alzheimer’s Disease Patients Receiving Cholinesterase Inhibitors: Data from the ICTUS Study. Phytomedicine, 21, 888-892. [Google Scholar] [CrossRef] [PubMed]
[19] Wilkins, T.L. and Sambamoorthi, U. (2011) Antidepressant Use, Depression, Lifestyle Factors, and New-Onset Diabetes. International Clinical Psychopharmacology, 26, 159-168. [Google Scholar] [CrossRef
[20] Carson, S., McDonagh, M.S. and Peterson, K. (2006) A Systematic Review of the Efficacy and Safety of Atypical Antipsychotics in Patients with Psychological and Behavioral Symptoms of Dementia. Journal of the American Geriatrics Society, 54, 354-361. [Google Scholar] [CrossRef] [PubMed]
[21] Schneider, L.S., Dagerman, K.S. and Insel, P. (2005) Risk of Death with Atypical Antipsychotic Drug Treatment for Dementia: Meta-Analysis of Randomized Placebo-Controlled Trials. JAMA, 294, 1934-1943. [Google Scholar] [CrossRef] [PubMed]
[22] Phiri, P., Engelthaler, T., Carr, H., et al. (2022) Associated Mortality Risk of Atypical Antipsychotic Medication in Individuals with Dementia. World Journal of Psychiatry, 12, 298. [Google Scholar] [CrossRef] [PubMed]
[23] Chan, T.-C., Luk, J.K.-H., Shea, Y.-F., et al. (2011) Continuous Use of Antipsychotics and Its Association with Mortality and Hospitalization in Institutionalized Chinese Older Adults: An 18-Month Prospective Cohort Study. International Psychogeriatrics, 23, 1640-1648. [Google Scholar] [CrossRef
[24] Ji, W., Gong, B., Jin, H., et al. (2021) Recent Progress towards Vaccines and Antibody-Based Therapies against Alzheimer’s Disease. Mini Reviews in Medicinal Chemistry, 21, 3062-3072. [Google Scholar] [CrossRef] [PubMed]
[25] Decourt, B., Boumelhem, F., Pope, E.D., et al. (2021) Critical Appraisal of Amyloid Lowering Agents in AD. Current Neurology and Neuroscience Reports, 21, 39. [Google Scholar] [CrossRef] [PubMed]
[26] Bang, O.Y. and Kim, J.-E. (2022) Stem Cell-Derived Extracel-lular Vesicle Therapy for Acute Brain Insults and Neurodegenerative Diseases. BMB Reports, 55, 20-29. [Google Scholar] [CrossRef
[27] Acharya, M.M., Christie, L.-A., Lan, M.L., et al. (2009) Rescue of Radiation-Induced Cognitive Impairment through Cranial Transplantation of Human Embryonic Stem Cells. Proceedings of the National Academy of Sciences of the United States of America, 106, 19150-19155. [Google Scholar] [CrossRef] [PubMed]
[28] Zhang, L., Zhao, P., Yue, C., et al. (2019) Sustained Release of Bioactive Hydrogen by Pd Hydride Nanoparticles Overcomes Alzheimer’s Disease. Biomaterials, 197, 393-404. [Google Scholar] [CrossRef] [PubMed]
[29] Cano, A., Turowski, P., Ettcheto, M., et al. (2021) Nanomedicine-Based Technologies and Novel Biomarkers for the Diagnosis and Treatment of Alzheimer’s Disease: From Current to Future Challenges. Journal of Nanobiotechnology, 19, 122. [Google Scholar] [CrossRef] [PubMed]
[30] Quail, Z., Carter, M.M., Wei, A., et al. (2020) Management of Cognitive Decline in Alzheimer’s Disease Using a Non-Pharmacological Intervention Program: A Case Report. Medicine, 99, e20128. [Google Scholar] [CrossRef
[31] Gold, K. (2014) But Does It Do Any Good? Measuring the Impact of Music Therapy on People with Advanced Dementia: (Innovative Practice). Dementia, 13, 258-264. [Google Scholar] [CrossRef] [PubMed]
[32] Pavlicevic, M., Tsiris, G., Wood, S., et al. (2015) The “Ripple Effect”: Towards Researching Improvisational Music Therapy in Dementia Care Homes. Dementia, 14, 659-679. [Google Scholar] [CrossRef] [PubMed]
[33] Popa, L.-C., Manea, M.C., Velcea, D., et al. (2021) Impact of Alzheimer’s Dementia on Caregivers and Quality Improvement through Art and Music Therapy. Healthcare, 9, 698. [Google Scholar] [CrossRef] [PubMed]
[34] Tung, B.T., Rodriguez-Bies, E., Thanh, H.N., et al. (2015) Organ and Tissue-Dependent Effect of Resveratrol and Exercise on Antioxidant Defenses of Old Mice. Aging Clinical and Experimental Research, 27, 775-783. [Google Scholar] [CrossRef] [PubMed]
[35] Sampaio, A., Marques-Aleixo, I., Seabra, A., et al. (2021) Phys-ical Exercise for Individuals with Dementia: Potential Benefits Perceived by Formal Caregivers. BMC Geriatrics, 21, 6. [Google Scholar] [CrossRef] [PubMed]
[36] Heyn, P.C., Johnsons, K.E. and Kramer, A.F. (2008) Endurance and Strength Training Outcomes on Cognitively Impaired and Cognitively Intact Older Adults: A Meta-Analysis. The Journal of Nutrition Health and Aging, 12, 401-409. [Google Scholar] [CrossRef
[37] Yin, W., Lv, G., Li, C., et al. (2021) Acupuncture Therapy for Alz-heimer’s Disease: The Effectiveness and Potential Mechanisms. The Anatomical Record, 304, 2397-2411. [Google Scholar] [CrossRef] [PubMed]
[38] Dempsey, L., Murphy, K., Cooney, A., et al. (2014) Reminiscence in De-mentia: A Concept Analysis. Dementia, 13, 176-192. [Google Scholar] [CrossRef] [PubMed]
[39] Mitchell, G. and Agnelli, J. (2015) Non-Pharmacological Approaches to Alleviate Distress in Dementia Care. Nursing Standard, 30, 38-44. [Google Scholar] [CrossRef] [PubMed]
[40] Deshmukh, S.R., Holmes, J. and Cardno, A. (2018) Art Therapy for People with Dementia. Cochrane Database of Systematic Reviews, 9, CD011073. [Google Scholar] [CrossRef
[41] Rentz, D.M., Locascio, J.J., Becker, J.A., et al. (2009) Cognition, Reserve and Amyloid Deposition in Normal Aging. Annals of Neurology, 67, 353-364. [Google Scholar] [CrossRef] [PubMed]