低分子肝素钠、肝素钙应用于早发型子痫前期患者辅助治疗效果及对机体肾功能及凝血功能的影响情况

Effect of Low-Molecular-Weight Heparin Sodium and Heparin Calcium in Adjuvant Treatment of Patients with Early-Onset Preeclampsia and Their Influence on Renal Function and Coagulation Function

摘要: 目的：探讨应用低分子肝素钠、肝素钙对早发型子痫前期患者辅助治疗中的作用。方法：随机抽取我院接收的早发型子痫前期患者84例，时间2019年5月至2020年5月，随机分为对照组和研究组，分别予以硫酸镁、硫酸镁 + 低分子肝素钠 + 肝素钙，两组治疗后肾功能及凝血功能对比。结果：治疗后研究组血尿酸、尿蛋白量低于对照组，且TT、APTT时间长于对照组，P < 0.05；两组Scr、尿素氮、PT对比无差异P > 0.05。结论：低分子肝素钠、肝素钙在妊娠子痫前期患者辅助治疗中可保护其肾功能，有效改善凝血功能，值得借鉴。

Abstract: Objective: To explore the role of low-molecular-weight heparin sodium and heparin calcium in the adjuvant treatment of patients with early-onset preeclampsia. Methods: A total of 84 patients with early-onset preeclampsia admitted to our hospital from May 2019 to May 2020 were randomly di-vided into a control group and a study group, which were treated with magnesium sulfate, magne-sium sulfate + low-molecular-weight heparin sodium + heparin calcium, respectively. The renal function and coagulation function were compared between the two groups after treatment. Results: After treatment, the blood uric acid and urine protein in the study group were lower than those in the control group, and the TT and APTT times were longer than those in the control group, P < 0.05. There was no significant difference in Scr, urea nitrogen and PT between the two groups (P > 0.05). Conclusions: Low molecular weight heparin sodium and heparin calcium can protect renal function and effectively improve coagulation function in the adjuvant treatment of patients with preeclamp-sia, which is worthy of reference.