超声引导下微波消融治疗对肝细胞肝癌患者心理状态及生活质量的影响

Effects of Ultrasound-Guided Microwave Ab-lation Therapy on Mental State and Quality of Life in Patients with Hepatocellular Carcinoma

摘要: 目的：本研究调查了微波消融治疗对肝细胞肝癌患者心理状态及生命质量的影响。方法：本研究纳入了2021年3月~5月在中国人民解放军总医院介入超声科治疗的154名肝细胞肝癌患者。欧洲癌症研究和治疗组织生活质量量表(EORTC QLQ-C30)和医院焦虑和抑郁量表(HADS)分别用来评估患者的生活质量和心理状态。收集患者术前及术后3个月、6个月、9个月、12个月的生活质量及心理状态量表结果。结果：本研究共纳入了154名患者。患者的平均年龄为61 ± 9.54岁，79%的患者为男性。患者在消融术前和消融术后3个月、6个月、9个月、12个月的生活质量得分分别为88.23 ± 8.15；85.80 ± 5.43 (P < 0.01)；87.06 ± 5.47 (P < 0.05)；87.63 ± 5.11和88.62 ± 5.66。焦虑的得分分别为4.10 ± 3.50；4.50 ± 3.10；4.30 ± 3.00；3.90 ± 3.00和3.30 ± 3.00。抑郁的得分分别为4.80 ± 3.70；5.30 ± 3.20；5.10 ± 3.10；4.90 ± 3.40和4.30 ± 3.60。结论：微波消融治疗能改善肝细胞肝癌患者的情绪困扰和生活质量。

Abstract: Objective: This study investigated the effects of microwave ablation (MWA) therapy on mental state and quality of life (QOL) in patients with hepatocellular carcinoma (HCC). Methods: A total of 154 patients with HCC who received interventional ultrasound treatment in the Chinese PLA General Hospital from March to May 2021 were enrolled in this study. The European Organization for Re-search and Treatment of Cancer Quality of Life Scale (EORTC QLQ-C30) and the Hospital Anxiety and Depression Scale (HADS) were used to assess patients’ QOL and psychological status, respectively. The results of QOL and mental state scale were collected before surgery and 3, 6, 9, and 12 months after MWA. Results: A total of 154 patients were included in this study. The mean age of the pa-tients was 61 ± 9.54 years, and 79% of the patients were male. QOL scores at baseline and at 3, 6, 9 and 12 months after ablation were 88.23 ± 8.15; 85.80 ± 5.43 (P < 0.01); 87.06 ± 5.47 (P < 0.05); 87.63 ± 5.11 and 88.62 ± 5.66, respectively. The scores of anxiety were 4.10 ± 3.50; 4.50 ± 3.10; 4.30 ± 3.00; 3.90 ± 3.00 and 3.30 ± 3.00, respectively. Depression scores were 4.80 ± 3.70; 5.30 ± 3.20; 5.10 ± 3.10; 4.90 ± 3.40 and 4.30 ± 3.60, respectively. Conclusion: MWA can improve emo-tional distress and QOL in patients with HCC.