盆腔肿瘤中肠道菌群与放射性肠炎的相关性

Correlation between Intestinal Flora and Radiation Enteritis in Pelvic Tumor

摘要: 盆腔放射治疗是盆腔恶性肿瘤的关键治疗手段，通常包括盆腔原发肿瘤病灶和盆腔淋巴引流区。在放射治疗中正常肠道会不可避免地受到损伤，这种现象临床上称为放射性肠炎(Radiation Enteritis)，肠道菌群在放射性肠炎发病中起关键作用，在盆腔放疗后患者肠道微生物群的种类和分布发生了显著变化。但目前相关研究较少尚未就微生物群组成的变化得出一致的结果。本文旨在探讨与总结肠道菌群与放射性肠炎的现有相关机制，回顾了目前的治疗选择，了解放射性肠炎发病与肠道菌群的关系，为检测肠道菌群的改变预测肿瘤患者放疗期间是否会出现放射性肠炎，可能获得潜在治疗效益。

Abstract: Pelvic radiation therapy is the key treatment for pelvic malignancies. It usually includes the pri-mary pelvic tumor lesion and pelvic lymphatic drainage area. Normal bowel is inevitably compro-mised during radiation therapy, i.e. this phenomenon is clinically called radiation enteritis. Intesti-nal flora plays a key role in the pathogenesis of radiation enteritis. The species and distribution of intestinal flora have significantly changed in patients following pelvic radiotherapy. However, few relevant studies have yet to reach consistent results regarding changes in flora composition. This paper aims to explore and summarize the existing mechanisms related to intestinal flora and radi-ation enteritis, review the current treatment options, and understand the relationship between the incidence of radiation enteritis and intestinal flora. In order to detect the changes in intestinal flora and predict whether radiation enteritis will occur in cancer patients during radiotherapy, potential therapeutic benefits may be obtained.