狼疮脑病合并史蒂文斯–约翰逊综合征一例并文献复习

Neuopsychiatric Systemic Lupus Erythematosus with Stevens-Johnson Syndrome: A Case Report and Literature Review

摘要: 系统性红斑狼疮(Systemic Lupus Erythematosus, SLE)是一种异质性自身免疫性疾病，其临床过程和预后各不相同，可累及全身各个器官系统。狼疮脑病(Neuopsychiatric Systemic Lupus Erythematosus, NPSLE)是其最严重的并发症之一，预后不良，死亡率极高。史蒂文斯–约翰逊综合征(Stevens-Johnson syndrome)是一种罕见的、急性、严重和潜在致命的皮肤反应，其中有片状皮肤和粘膜脱落，并伴有全身症状。这两种病症的临床表现及治疗都有相通之处。本文报道青岛大学附属医院风湿免疫科于2022-09-09收治的狼疮脑病合并史蒂文斯–约翰逊综合征1例，对其临床特征、诊断及治疗进行分析总结，并进行文献复习，提高对此病症的警惕性，提高临床诊断水平，及时制定有效治疗方案。

Abstract: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease with different clinical processes and prognosis, which can affect all organs and systems of the body. Neuopsychiatric sys-temic lupus erythematosus (NPSLE) is one of the most serious complications of SLE, with poor prognosis and high mortality. Stevens-Johnson syndrome is a rare, acute, serious and potentially fatal skin reaction, in which flaky skin and mucous membrane are exfoliated and accompanied by systemic symptoms. The clinical manifestations and treatment of these two diseases are similarities. This paper reports a case of Neuopsychiatric systemic lupus erythematosus with Stevens-Johnson syndrome in the affiliated Hospital of Qingdao University from September 9, 2022 to analyze and summarize its clinical features, diagnosis and treatment, and review the literature to improve the vigilance of the disease and formulate an effective treatment plan in time.