S100A7蛋白在宫颈鳞癌中的表达分析

Expression Analysis of S100A7 Protein in Cervical Squamous Cell Carcinoma

摘要: 目的：分析S100A7蛋白的表达量与宫颈鳞癌患者各个临床病理指标之间的关系，探讨该蛋白在宫颈鳞癌中的表达与肿瘤分化、侵袭、转移之间的关系。方法：选取2016年5月至2021年4月因宫颈鳞癌在青岛大学附属医院妇科行手术切除的标本49例，采用免疫组化的方法，对S100A7蛋白进行半定量分析，收集整理宫颈鳞癌患者的临床病理信息，运用统计学方法分析S100A7蛋白表达量与各临床病理参数之间的关系。结果：宫颈鳞癌中，S100A7蛋白的表达量与肿瘤分化、淋巴结转移有关，与发病年龄、肿瘤大小、FIGO分期、脉管转移无关。结论：S100A7蛋白与宫颈鳞癌分化、淋巴结转移有关，S100A7蛋白表达上调可能与宫颈鳞癌发生、进展、侵袭、转移有关。

Abstract: Objective: To analyze the relationship between the expression of S100A7 protein and various clini-copathological indicators in patients with cervical squamous carcinoma, and to explore the rela-tionship between the expression of this protein in cervical squamous carcinoma and tumor differ-entiation, invasion and metastasis. Methods: Forty-nine specimens with surgical resection for cer-vical squamous carcinoma in the Department of Gynecology, Affiliated Hospital of Qingdao Univer-sity were selected from May 2016 to April 2021, and the S100A7 protein was analyzed semi-quantitatively by immunohistochemistry. The clinicopathological information of patients with cervical squamous carcinoma was collected and collated. The relationship between S100A7 protein expression and various clinicopathological parameters was analyzed by using statistical methods. Results: In squamous carcinoma of the cervix, the expression of S100A7 protein was associated with tumor differentiation and lymph node metastasis, but not with age at onset, tumor size, FIGO stage and vascular metastasis. Conclusions: S100A7 protein was associated with cervical squamous car-cinoma differentiation and lymph node metastasis, and up-regulation of S100A7 protein expression may be related to cervical squamous carcinoma occurrence, progression, invasion and metastasis.