冠状动脉粥样硬化性心脏病患者血清炎症指标与血脂水平相关性的研究

Study on the Correlation between Serum Inflammatory Markers and Lipid Levels in Patients with Coronary Heart Disease

摘要: 目的：探讨冠状动脉粥样硬化性心脏病(Coronary atherosclerotic heart disease, CHD)患者血清中炎症指标水平与血脂水平相关性，进一步证明慢性炎症反应是诱发CHD的重要原因。方法：收集我院33例CHD合并高脂血症患者的血清样本和29例单纯CHD患者的血清样本，采用ELISA法检测血清中炎性因子IL-1β、IL-6和TNF-α的水平，结合hs-CRP的水平，分析炎症指标与患者血脂水平TC、TG和LDL-C的相关性。结果：与单纯CHD组相比，CHD合并高脂血症患者的炎症指标hs-CRP、IL-1β和TNF-α与血脂指标TC、TG和LDL-C存在显著的相关性。结论：体内慢性炎症反应在CHD的发生中具有重要意义。

Abstract: Objective: To investigate the correlation between serum inflammatory markers and lipid levels in patients with coronary atherosclerotic heart disease (CHD), further proving that chronic inflam-matory response is an important cause of CHD. Method: Serum samples of 33 patients with CHD combined with hyperlipidemia and 29 patients with CHD alone were collected in our hospital. The levels of inflammatory factors IL-1β, IL-6 and TNF-α in serum were detected by ELISA, combined with the levels of hs-CRP, and the correlation between inflammatory indicators and the levels of TC, TG and LDL-C in patients was analyzed. Results: Compared with CHD group, hs-CRP, IL-1β and TNF-α were significantly correlated with TC, TG and LDL-C in CHD patients with hyperlipidemia. Conclusion: Chronic inflammatory response plays an important role in the development of CHD.