慢性阻塞性肺病水液代谢障碍研究进展
Research Progress of Chronic Obstructive Pulmonary Disease Water and Fluid Metabolism Disorder
DOI: 10.12677/ACM.2023.133522, PDF,   
作者: 马海滨：新疆医科大学第四临床医学院，新疆 乌鲁木齐；李风森：新疆医科大学第四临床医学院，新疆 乌鲁木齐；新疆医科大学附属中医医院呼吸科，新疆 乌鲁木齐
关键词: COPD；RAAS；AQP；通调水道；水液代谢；COPD； RAAS； AQP； Pulmonary Ventilation Channel； Water and Fluid Metabolism
摘要: “肺主行水，通调水道”指肺气的宣发肃降，是人体内津液运转的重要力量。肺通调水道功能障碍，往往会导致慢性阻塞性肺部疾患(COPD)患者的水液代谢障碍，出现外周性水肿、排尿异常等症状。引起水液代谢失调的机理是相当复杂的，有资料指出与肾素–血管紧张素–醛固酮系统(RAAS)和水通道蛋白(AQP)等密切相关。本文根据“肺通调水道”的学说，介绍了水通道蛋白COPD发生发展中的重要性，对COPD的有效防治和进一步深入研究带来了新意。
Abstract: The lung mainly carries water, and the channel of regulating means that the promotion and descent of lung qi is the main driving force of body fluid operation. The dysfunction of the pulmonary chan-nel way often causes water and fluid metabolism disorders in patients with chronic obstructive pulmonary disease (COPD) and the occurrence of peripheral edema, abnormal urination and other symptoms. The mechanisms underlying the development of fluid retention are complex and have been shown to be closely related to the renin-angiotensin-aldosterone system (RAAS) and aqua-porin (AQP). This paper expounds the significance of aquaporin in the occurrence and development of COPD based on the theory of “lung ventilation and channel regulation”, and provides new ideas for the treatment and further study of COPD.
文章引用：马海滨, 李风森. 慢性阻塞性肺病水液代谢障碍研究进展[J]. 临床医学进展, 2023, 13(3): 3643-3650. https://doi.org/10.12677/ACM.2023.133522

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