扩张型心肌病相关致病基因的研究进展
Research Progress of Pathogenic Genes Associated with Dilated Cardiomyopathy
DOI: 10.12677/ACM.2023.133525, PDF,   
作者: 王 姚, 胡 蓉, 杜建霖*：重庆医科大学附属第二医院心血管内科，重庆
关键词: 扩张型心肌病；致病基因；基因突变；Dilated Cardiomyopathy； Pathogenic Gene； Gene Mutations
摘要: 扩张型心肌病(DCM)是一种心肌疾病，以结构(心室扩大)和功能(心肌收缩力降低)异常为特征，发病时除外高血压、心脏瓣膜病、先天性心脏病或缺血性心脏病等，病死率高，预后差，5年病死率为15%~50%。目前扩张型心肌病病因尚不明确，有研究表明扩张型心肌病是遗传异质性的，可通过筛选易感基因对扩张型心肌病进行早诊断、早治疗，现就近年来DCM致病基因研究做简要综述。
Abstract: Dilated Cardiomyopathy (DCM) is a myocardial disorder characterized by structural (ventricular enlargement) and functional (decreased myocardial contractility) abnormalities, excluding hyper-tension, valvular heart disease, congenital heart disease, or ischemic heart disease. Dilated cardio-myopathy has a high mortality rate and poor prognosis, with a 5-year case fatality rate of 15% to 50%. At present, the cause of dilated cardiomyopathy is not clear, some studies have shown that dilated cardiomyopathy is genetically heterogeneous, and dilated cardiomyopathy can be diag-nosed and treated early by screening susceptibility genes. This is a brief review of the research on DCM pathogenic genes in recent years.
文章引用：王姚, 胡蓉, 杜建霖. 扩张型心肌病相关致病基因的研究进展[J]. 临床医学进展, 2023, 13(3): 3663-3670. https://doi.org/10.12677/ACM.2023.133525

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