自身免疫特征间质性肺病研究进展
Advances in Clinical Research of Interstitial Lung Disease with Autoimmune Characteristics
DOI: 10.12677/ACM.2023.133538, PDF,  被引量   
作者: 白祥梅, 席 磊, 杨 柳, 王 玲*:新疆医科大学第四临床医学院,新疆 乌鲁木齐
关键词: 间质性肺病自身免疫结缔组织疾病Interstitial Lung Disease Autoimmune Features Connective Tissue Disease
摘要: 具有自身免疫特征的间质性肺病(IPAF)是一组在自身免疫抗体和肺部高分辨CT上都具有典型的结缔组织病(CTD)临床表现的疾病。在间质性肺病(ILD)的临床诊断和治疗中,发现有相当数量的患者同时具有类风湿免疫病的自身抗体和肺部CT表现,但却不符合CTD的诊断标准。2015年,IPAF的诊断标准出台,为管理和分类这些患者确立了方向和参考标准。本文回顾了IPAF在诊断标准、临床特征和治疗方面的研究进展。
Abstract: Interstitial lung disease with autoimmune features (IPAF) is a group of diseases with typical clinical manifestations of connective tissue disease (CTD) on both autoimmune antibodies and high- resolu-tion CT of the lung. In the clinical diagnosis and treatment of interstitial lung disease (ILD), it is found that a considerable number of patients have both autoantibodies of rheumatoid immune disease and lung CT manifestations, but they do not meet the diagnostic criteria of CTD. In 2015, diagnostic criteria for IPAF were introduced, which established direction and reference standards for the management and classification of these patients. This article reviews the advances in diag-nostic criteria, clinical features, and treatment of IPAF.
文章引用:白祥梅, 席磊, 杨柳, 王玲. 自身免疫特征间质性肺病研究进展[J]. 临床医学进展, 2023, 13(3): 3752-3758. https://doi.org/10.12677/ACM.2023.133538

参考文献

[1] 梁艳霞, 樊茂蓉, 王冰, 赵媛, 马卉, 张子然, 丛晓东. 结缔组织病相关间质性肺病中医病因病机及治疗研究进展[J]. 中国医药导报, 2022, 19(15): 33-36.
[2] 卞大晨, 肖永龙, 刘布俊, 等. 结缔组织疾病相关性间质性肺病与特发性间质性肺炎比较研究[J]. 中国呼吸与危重监护杂志, 2014, 13(3): 263-267.
[3] Fischer, A., Antoniou, K.M., Brown, K.K., et al. (2015) An Official European Respiratory Society/American Thoracic Society Research State-ment: Interstitial Pneumonia with Autoimmune Features. European Respiratory Journal, 46, 976-987. [Google Scholar] [CrossRef] [PubMed]
[4] Jee, A.S., Adelstein, S., Bleasel, J., et al. (2017) Role of Au-toantibodies in the Diagnosis of Connective-Tissue Disease ILD (CTD-ILD) and Interstitial Pneumonia with Autoim-mune Features (IPAF). Journal of Clinical Medicine, 6, 51. [Google Scholar] [CrossRef] [PubMed]
[5] Jee, A.S., Sheehy, R., Hopkins, P., et al. (2021) Diagnosis and Manage-ment of Connective Tissue Disease-Associated Interstitial Lung Disease in Australia and New Zealand: A Position Statement from the Thoracic Society of Australia and New Zealand. Respirology, 26, 23-51. [Google Scholar] [CrossRef] [PubMed]
[6] Fernandes, L., Nasser, M., Ahmad, K., et al. (2019) Interstitial Pneumonia with Autoimmune Features (IPAF). Frontiers in Medicine (Lausanne), 6, 209. [Google Scholar] [CrossRef] [PubMed]
[7] 黄慧, 胡立星, 徐作君. 具有自身免疫特征的间质性肺炎的命名及诊断标准(摘译)——欧洲呼吸病学会和美国胸科学会官方共识[J]. 中华结核和呼吸杂志, 2016, 39(6): 433-437.
[8] 赛晓焱, 蔡后荣. 具有自身免疫特征的间质性肺炎研究进展[J]. 中国呼吸与危重监护杂志, 2017, 16(3): 300-304.
[9] 原庆, 刘建, 郭丽娅, 等. 具有自身免疫特征的间质性肺炎患者中西医临床信息分析[J]. 中国中医基础医学杂志, 2018, 24(8): 1106-1108.
[10] 郑雅文, 高鑫, 苗裔, 等. 具有自身免疫特征的间质性肺炎的临床特征及转归[J]. 河南医学研究, 2020, 29(35): 6529-6532.
[11] Chartrand, S., Lee, J.S., Swigris, J.J., Stanchev, L. and Fischer, A. (2019) Clinical Characteristics and Natural History of Autoimmune Forms of Interstitial Lung Disease: A Single-Center Experience. Lung, 197, 709-713. [Google Scholar] [CrossRef] [PubMed]
[12] Ahmad, K., Barba, T., Gamondes, D., Ginoux, M., et al. (2017) Interstitial Pneumonia with Autoimmune Features: Clinical, Radiologic, and Histological Characteristics and Outcome in a Series of 57 Patients. Respiratory Medicine, 123, 56-62. [Google Scholar] [CrossRef] [PubMed]
[13] Oldham, J.M., Adegunsoye, A., Valenzi, E., et al. (2016) Characterisation of Patients with Interstitial Neumonia with Autoimmune Features. European Respiratory Journal, 47, 1767-1775. [Google Scholar] [CrossRef] [PubMed]
[14] Ferri, C., Manfredi, A., Sebastiani, M., et al. (2016) Interstitial Pneumonia with Autoimmune Features and Undifferentiated Connective Tissue Disease: Our Interdisciplinary Rheumatology-Pneumology Experience, and Review of the Literature. Autoimmunity Reviews, 15, 61-70. [Google Scholar] [CrossRef] [PubMed]
[15] 郭红敏. 不同结缔组织病肺间质病变(CTD-ILD)的临床特点及治疗效果[J]. 中国保健营养, 2016, 26(16): 136.
[16] 刘倩. 结缔组织病肺间质病变的临床特征及血清标志物的研究[D]: [硕士学位论文]. 广州: 南方医科大学, 2015.
[17] 王宁. IPAF的临床特征及影响其死亡的危险因素分析[D]: [硕士学位论文]. 秦皇岛: 华北理工大学, 2021.
[18] Cottin, V., Crestani, B., Cadranel, J., et al. (2017) French Practical Guidelines for the Diagnosis and Management of Idiopathic Pulmonary Fibrosis—2017 Update. Full-Length Version. Revue des Maladies Respiratoires, 34, 900-968. [Google Scholar] [CrossRef] [PubMed]
[19] 闫宏. 基于数据挖掘的姜良铎教授治疗结缔组织病相关肺间质疾病经验研究[D]: [硕士学位论文]. 北京: 北京中医药大学, 2021.
[20] Wiertz, I.A., van Moorsel, C.H.M., Vorselaars, A.D.M., et al. (2018) Cyclophosphamide in Steroid Refractory Unclassifiable Idiopathic Interstitial Pneumo-nia and Interstitial Pneumonia with Autoimmune Features (IPAF). European Respiratory Journal, 51, Article ID: 1702519. [Google Scholar] [CrossRef] [PubMed]
[21] Antoniou, K.M., Margaritopoulos, G., Economidou, F., et al. (2009) Pivotal Clinical Dilemmas in Collagen Vascular Diseases Associated with Interstitial Lung Involvement. European Respiratory Journal, 3, 882-896. [Google Scholar] [CrossRef] [PubMed]
[22] Tashkin, D.P., Roth, M.D., Clements, P.J., et al. (2016) Myco-phenolate Mofetil versus Oral Cyclophosphamide in Scleroderma-Related Interstitial Lung Disease (SLS II): A Random-ised Controlled, Double-Blind, Parallel Group Trial. The Lancet Respiratory Medicine, 4, 708-719. [Google Scholar] [CrossRef
[23] McCoy, S.S., Mukadam, Z., Meyer, K.C., et al. (2018) My-cophenolate Therapy in Interstitial Pneumonia with Autoimmune Features: A Cohort Study. Therapeutics and Clinical Risk Management, 14, 2171-2181. [Google Scholar] [CrossRef
[24] Distler, O., Highland, K.B., Gahlemann, M., et al. (2019) Nintedanib for Systemic Sclerosis-Associated Interstitial Lung Disease. The New England Journal of Medicine, 380, 2518-2528. [Google Scholar] [CrossRef
[25] Solomon, J.J., Danoff, S.K., Goldberg, H.J., et al. (2019) The De-sign and Rationale of the Trail1 Trial: A Randomized Double-Blind Phase 2 Clinical Trial of Pirfenidone in Rheumatoid Arthritis-Associated Interstitial Lung Disease. Advances in Therapy, 36, 3279-3287. [Google Scholar] [CrossRef] [PubMed]
[26] 张萌. 吡非尼酮对特发性间质性肺炎外周血清KL-6水平的影响[D]: [硕士学位论文]. 石家庄: 河北医科大学, 2017.
[27] Maher, T.M., Corte, T.J., Fischer, A., et al. (2020) Pirfenidone in Patients with Unclassifiable Progressive Fibrosing Interstitial Lung Disease: A Double-Blind, Randomised, Placebo-Controlled, Phase 2 Trial. The Lancet Respiratory Medicine, 8, 147-157. [Google Scholar] [CrossRef
[28] 赵书山, 王健. 自身免疫特征的间质性肺炎研究进展[J]. 浙江医学, 2020, 42(18): 2021-2024.
[29] 唐攀. 具有自身免疫特征的间质性肺炎KL-6、MMP-7和CCL-18表达水平检测及临床特征分析[D]: [硕士学位论文]. 宁波: 宁波大学, 2020.
[30] Luppi, F. and Wells, A.U. (2016) In-terstitial Pneumonitis with Autoimmune Features (IPAF): A Work in Progress. European Respiratory Journal, 47, 1622-1624. [Google Scholar] [CrossRef] [PubMed]