慢性心力衰竭患者血清SGK1水平的变化

Changes in Serum SGK1 Levels in Patients with Chronic Heart Failure

摘要: 目的：探索慢性心力衰竭患者血清中SGK1水平的变化，分析其与心衰的关系。方法：收集103例慢性心衰患者作为慢性心力衰竭组(Chronic heart failure group, HF组)，103例同期健康体检者作为非慢性心力衰竭组(Non-Chronic heart failure group, non-HF组)，采用ELISA方法测定两组样本血清SGK1水平，同时收集相关临床资料进行统计学分析。结果：与non-HF组相比，HF组血清SGK1浓度显著升高，差异有统计学意义(P < 0.001)。采用Spearman相关分析发现血清SGK1水平与NT-ProBNP呈正相关(P < 0.05)，与LVEF呈负相关(P < 0.05)。二分类Logistic回归分析发现SGK1 (OR = 12.012, 95% CI 1.726~83.592)是慢性心力衰竭的独立危险因素。联合SGK1和NT-proBNP两指标绘制ROC曲线，可提高CHF诊断的特异性及敏感度。结论：CHF患者血清SGK1水平明显升高。血清SGK1水平是CHF的独立危险因素，联合检测SGK1及NT-proBNP水平能提高CHF诊断的准确性。

Abstract: Objective: To explore the changes of SGK1 level in serum of chronic heart failure patients and ana-lyze the relationship between it and heart failure. Methods: 103 patients with chronic heart failure were collected as chronic heart failure group (HF group) and 103 patients with non-chronic heart failure group (non-HF group) were collected from the same period. The serum SGK1 levels were measured by ELISA and the relevant clinical data were collected for statistical analysis. Results: Serum SGK1 concentrations were significantly higher in the HF group compared with the non-HF group, and the difference was statistically significant (P < 0.001). Spearman correlation analysis was used to find that serum SGK1 levels were positively correlated with NT-ProBNP (P < 0.05) and nega-tively correlated with LVEF (P < 0.05). Dichotomous logistic regression analysis found SGK1 (OR = 12.012, 95% CI 1.726~83.592) to be an independent risk factor for chronic heart failure. Combining both SGK1 and NT-proBNP indicators to draw ROC curves can improve the specificity and sensitivity of CHF diagnosis. Conclusion: Serum SGK1 levels were significantly elevated in CHF patients. Serum SGK1 level is an independent risk factor for CHF, and combined detection of SGK1 and NT-proBNP levels can improve the accuracy of CHF diagnosis.