常规超声引导困难的肝恶性肿瘤在不同影像引导方式下行消融治疗的研究进展
Research Progress in the Different Image-Guided Ablation of Malignant Liver Tumors for Which Conventional Ultrasound Guidance Is Difficult
DOI: 10.12677/ACM.2023.133542, PDF,   
作者: 郭晓彤, 李成利*:山东大学医学融合与实践中心,山东 济南;山东省立医院,山东 济南
关键词: 肝恶性肿瘤超声引导困难热消融影像引导Liver Tumor Difficulty in Ultrasonic Guidance Thermal Ablation Image Guidance
摘要: 随着医学成像技术的进步,肝肿瘤的早期诊断率不断提高,根据中国肝癌临床分期与治疗路线图,消融技术目前认为是治疗极早期肝癌、不能手术的肝癌和少结节性肝转移瘤的推荐治疗方法,超声是最常用于肝恶性肿瘤消融治疗的影像引导方式,但并不是所有肝内病变都可以在常规超声影像上清晰显示或有安全的进针路径,随着电磁导航、增强影像等技术的发展,已经有多种影像引导方式用于克服此类难题,本文将针对常规超声引导困难的肝恶性肿瘤,在不同影像引导方式下行消融治疗的最新研究进展进行概述。
Abstract: Major advances in medical imaging technologies have continued to improve rates of liver tumor di-agnosis during the early stages of disease. Per the clinical staging and treatment roadmap of hepa-tocellular carcinoma in China, ablation techniques are currently considered to be the recommended treatment for early-stage or inoperable liver cancer, and some cases of nodular liver metastases. The most commonly used imaging guidance for ablation procedures targeting liver tumors is ultra-sound-based. However, some hepatic lesions fail to display well on ultrasound images, while in other cases a safe injection path may not be visible. The development of novel enhanced imaging tech-niques, electromagnetic navigation approaches, and other technologies has provided new opportu-nities for guidance aimed at overcoming this issue. The present study summarizes the most recent progress in research focused on ablation therapy as a treatment for malignant liver tumors that are poorly suited to conventional ultrasound guidance.
文章引用:郭晓彤, 李成利. 常规超声引导困难的肝恶性肿瘤在不同影像引导方式下行消融治疗的研究进展[J]. 临床医学进展, 2023, 13(3): 3782-3787. https://doi.org/10.12677/ACM.2023.133542

参考文献

[1] 原发性肝癌诊疗指南(2022年版) [J]. 中国实用外科杂志, 2022(3): 241-273.
[2] Lin, Z., Chen, J., Yan, Y., et al. (2019) Microwave Ablation of Hepatic Malignant Tumors Using 1.5T MRI Guidance and Monitoring: Feasibility and Preliminary Clinical Experience. International Journal of Hyperthermia, 36, 1216-1222. [Google Scholar] [CrossRef] [PubMed]
[3] Minami, Y., Minami, T., Hagiwara, S., et al. (2018) Ultra-sound-Ultrasound Image Overlay Fusion Improves Real-Time Control of Radiofrequency Ablation Margin in the Treat-ment of Hepatocellular Carcinoma. European Radiology, 28, 1986-1993. [Google Scholar] [CrossRef] [PubMed]
[4] Minami, Y. and Kudo, M. (2021) Image Guidance in Ablation for Hepatocellular Carcinoma: Contrast-Enhanced Ultrasound and Fusion Imaging. Frontiers in Oncology, 11, Article ID: 593636. [Google Scholar] [CrossRef] [PubMed]
[5] Xu, E., Long, Y., Li, K., et al. (2019) Comparison of CT/MRI-CEUS and US-CEUS Fusion Imaging Techniques in the Assessment of the Thermal Ablation of Liver Tumors. International Journal of Hyperthermia, 35, 159-167. [Google Scholar] [CrossRef] [PubMed]
[6] Dong, Y., Wang, W.P., Mao, F., et al. (2016) Application of Imaging Fusion Combining Contrast-Enhanced Ultrasound and Magnetic Resonance Imaging in Detection of Hepatic Cellular Carcinomas Undetectable by Conventional Ultrasound. Journal of Gastroenterology and Hepatology, 31, 822-828. [Google Scholar] [CrossRef] [PubMed]
[7] Ahn, S.J., Lee, J.M., Lee, D.H., et al. (2017) Real-time US-CT/MR Fusion Imaging for Percutaneous Radiofrequency Ablation of Hepatocellular Carcinoma. Journal of Hepa-tology, 66, 347-354. [Google Scholar] [CrossRef] [PubMed]
[8] Mauri, G., Cova, L., de Beni, S., et al. (2015) Real-Time US-CT/MRI Image Fusion for Guidance of Thermal Ablation of Liver Tumors Undetectable with US: Results in 295 Cases. CardioVascular and Interventional Radiology, 38, 143-151. [Google Scholar] [CrossRef] [PubMed]
[9] Barr, R.G., Huang, P., Luo, Y., et al. (2020) Contrast-Enhanced Ultrasound Imaging of the Liver: A Review of the Clinical Evidence for Sonovue and Sonazoid. Abdominal Radiology (NY), 45, 3779-3788. [Google Scholar] [CrossRef] [PubMed]
[10] Numata, K., Isozaki, T., Ozawa, Y., et al. (2003) Percutaneous Ablation Therapy Guided by Contrast-Enhanced Sonography for Patients with Hepatocellular Carcinoma. AJR American Journal of Roentgenology, 180, 143-149. [Google Scholar] [CrossRef] [PubMed]
[11] Francica, G., Meloni, M.F., Riccardi, L., et al. (2018) Ablation Treatment of Primary and Secondary Liver Tumors under Contrast-Enhanced Ultrasound Guidance in Field Practice of Interventional Ultrasound Centers. A Multicenter study. European Journal of Radiology, 105, 96-101. [Google Scholar] [CrossRef] [PubMed]
[12] Kim, E.J., Kim, Y.S., Shin, S.K., et al. (2017) Contrast-Enhanced Ultrasound-Guided Radiofrequency Ablation in Inconspicuous Hepatocellular Carcinoma on B-Mode Ultrasound. Turk-ish Journal of Gastroenterology, 28, 446-452. [Google Scholar] [CrossRef] [PubMed]
[13] Bansal, S., Gui, J., Merrill, C., et al. (2019) Contrast-Enhanced US in Local Ablative Therapy and Secondary Surveillance for Hepatocellular Carcinoma. Radiographics, 39, 1302-1322. [Google Scholar] [CrossRef] [PubMed]
[14] Liu, F., Yu, X., Liang, P., et al. (2011) Contrast-Enhanced Ultra-sound-Guided Microwave Ablation for Hepatocellular Carcinoma Inconspicuous on Conventional Ultrasound. Interna-tional Journal of Hyperthermia, 27, 555-562. [Google Scholar] [CrossRef] [PubMed]
[15] Yu, N.C., Chaudhari, V., Raman, S.S., et al. (2011) CT and MRI Improve Detection of Hepatocellular Carcinoma, Compared with Ultrasound Alone, in Patients with Cirrhosis. Clinical Gastroenterology and Hepatology, 9, 161-167. [Google Scholar] [CrossRef] [PubMed]
[16] Li, X.Q., Wang, X., Zhao, D.W., et al. (2020) Application of Gd-EOB-DTPA-Enhanced Magnetic Resonance Imaging (MRI) in Hepatocellular Carcinoma. World Journal of Surgical Oncology, 18, 219. [Google Scholar] [CrossRef] [PubMed]
[17] Ronot, M., Purcell, Y. and Vilgrain, V. (2019) Hepatocellular Carcinoma: Current Imaging Modalities for Diagnosis and Prognosis. Digestive Diseases and Sciences, 64, 934-950. [Google Scholar] [CrossRef] [PubMed]
[18] Chen, J., Lin, Z., Lin, Q., et al. (2020) Percutaneous Radiofre-quency Ablation for Small Hepatocellular Carcinoma in Hepatic Dome under MR-Guidance: Clinical Safety and Efficacy. International Journal of Hyperthermia, 37, 192-201. [Google Scholar] [CrossRef] [PubMed]
[19] Xu, K., Li, Z., Wang, C., et al. (2022) 3.0-T Closed MR-Guided Microwave Ablation for HCC Located under the Hepatic Dome: A Single-Center Experience. International Journal of Hyperthermia, 39, 1044-1051. [Google Scholar] [CrossRef] [PubMed]
[20] 李成利, 韩沛伦, 王立刚, 等. 高场开放式MR自由手透视技术导引冷冻消融37例膈顶部肝细胞癌临床实践[J]. 肝癌电子杂志, 2017, 4(4): 51-57.
[21] Durand, P., Mo-reau-Gaudry, A., Silvent, A.S., et al. (2017) Computer Assisted Electromagnetic Navigation Improves Accuracy in Computed Tomography Guided Interventions: A Prospective Randomized Clinical Trial. PLOS ONE, 12, e0173751. [Google Scholar] [CrossRef] [PubMed]
[22] Ahmed, M., Solbiati, L., Brace, C.L., et al. (2014) Im-age-Guided Tumor Ablation: Standardization of Terminology and Reporting Criteria—A 10-Year Update. Radiology, 273, 241-260. [Google Scholar] [CrossRef] [PubMed]
[23] 章浙伟, 刘璐璐, 邵国良, 等. 四维电磁导航系统辅助CT引导下肝肿瘤热消融的临床应用[J]. 介入放射学杂志, 2018, 27(8): 750-754.
[24] Zhang, Z., Shao, G., Zheng, J., et al. (2020) Electromagnetic Navigation to Assist with Computed Tomography-Guided Thermal Ablation of Liver Tumors. Minimally Invasive Therapy & Allied Technologies, 29, 275-282. [Google Scholar] [CrossRef] [PubMed]
[25] Volpi, S., Tsoumakidou, G., Loriaud, A., et al. (2019) Elec-tromagnetic Navigation System Combined with High-Fre- quency-Jet-Ventilation for CT-Guided Hepatic Ablation of Small US-Undetectable and Difficult to Access Lesions. International Journal of Hyperthermia, 36, 1051-1057. [Google Scholar] [CrossRef] [PubMed]