氧化应激在胃癌中的研究进展
Research Progress of Oxidative Stress in Gastric Cancer
DOI: 10.12677/ACM.2023.133562, PDF,   
作者: 周 璇, 李林俞, 潘旭红：甘肃中医药大学第一临床医学院，甘肃 兰州；甘肃省人民医院肿瘤内科，甘肃 兰州；李红玲*：甘肃省人民医院肿瘤内科，甘肃 兰州
关键词: 氧化应激；胃癌；机制；预防；治疗；Oxidative Stress； Gastric Cancer； Mechanism； Prevention； Treatment
摘要: 胃癌(GC)是世界上癌症死亡率最高的原因之一，因其侵袭性强，生存率低，复发转移率高，严重威胁着全球44亿人类的健康。氧化应激是一种由机体内氧化过程中的基因突变、氧化分子的增加以及抗氧化剂的减少所造成的危害。氧化应激学说是胃癌发生和发展机制研究中的重要学说之一，这两者之间的关系一直备受关注。本文就这一话题结合国内外研究结果，分别介绍了氧化应激的定义、胃癌的基本概念和细胞氧化应激能够产生的各种损害。重点介绍了氧化应激的发病机制和胃癌的临床特征，并且总结了氧化应激在胃癌中的作用。通过调控氧化应激的分子机制来预防和治疗胃癌，或可能成为GC诊断及治疗研究的方向。
Abstract: Gastric cancer (GC) is one of the causes of the highest cancer mortality in the world. Due to its strong invasiveness, low survival rate and high recurrence and metastasis rate, GC poses a serious threat to the health of 4.4 billion people worldwide. Oxidative stress is a harm caused by genetic mutations in the body’s oxidation process, an increase in oxidative molecules, and a decrease in antioxidants. The theory of oxidative stress is one of the important theories in the study of the pathogenesis and development of gastric cancer, and the relationship between the two has attracted much attention. This paper introduces the definition of oxidative stress, the basic concept of gastric cancer and the damage caused by cellular oxidative stress. This paper focuses on the pathogenesis of oxidative stress and the clinical features of gastric cancer, and summarizes the role of oxidative stress in gastric cancer. The prevention and treatment of gastric cancer by regulating the molecular mechanism of oxidative stress may become the direction of GC diagnosis and treatment.
文章引用：周璇, 李林俞, 潘旭红, 李红玲. 氧化应激在胃癌中的研究进展[J]. 临床医学进展, 2023, 13(3): 3919-3925. https://doi.org/10.12677/ACM.2023.133562

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