YBX1在组织器官纤维化中作用的研究进展
Research Progress on the Role of YBX1 in Tissue and Organ Fibrosis
DOI: 10.12677/ACM.2023.133594, PDF,    科研立项经费支持
作者: 李德莲：青海大学研究生院，青海 西宁；苏晓灵*：青海省人民医院心血管内科，青海 西宁
关键词: Y盒结合蛋白1；纤维化；microRNA；YBX1； Fibroblast； microRNA
摘要: YBX1作为多功能结合蛋白，参与多种细胞过程，通过TGF-β通路、炎性因子、介导上皮间质转化、调节胶原蛋白的表达等多种机制，发挥致纤维化作用，YBX1有可能成为治疗纤维化的新靶点。
Abstract: As a multifunctional binding protein, YBX1 is involved in a variety of cellular processes. It plays a fibrogenic role through TGF-β pathway, inflammatory factors, mediating epithelial interstitial transformation, regulating collagen expression and other mechanisms. YBX1 may become a new target for the treatment of fibrosis.
文章引用：李德莲, 苏晓灵. YBX1在组织器官纤维化中作用的研究进展[J]. 临床医学进展, 2023, 13(3): 4136-4140. https://doi.org/10.12677/ACM.2023.133594

参考文献

[1] Henderson, N.C., Rieder, F. and Wynn, T.A. (2020) Fibrosis: From Mechanisms to Medicines. Nature, 587, 555-566. [Google Scholar] [CrossRef] [PubMed]
[2] Pinzani, M. and Parola, M. (2019) Pathophysiology of Organ and Tissue Fibrosis. Molecular Aspects of Medicine, 65, 1-110. [Google Scholar] [CrossRef] [PubMed]
[3] Wynn, T.A. (2004) Fibrotic Disease and the T(H)1/T(H)2 Paradigm. Nature Reviews. Immunology, 4, 583-594. [Google Scholar] [CrossRef] [PubMed]
[4] Weiskirchen, R., Weiskirchen, S. and Tacke, F. (2019) Organ and Tissue Fi-brosis: Molecular Signals, Cellular Mechanisms and Translational Implications. Molecular Aspects of Medicine, 65, 2-15. [Google Scholar] [CrossRef] [PubMed]
[5] Rockey, D.C., Bell, D. and Hill, J.A. (2015) Fibrosis—A Com-mon Pathway to Organ Injury and Failure. The New England Journal of Medicine, 372, 1138-1149. [Google Scholar] [CrossRef] 
[6] Lang, M.J., et al. (2021) LncRNA MHRT Promotes Cardiac Fibro-sis via miR-3185 Pathway Following Myocardial Infarction. International Heart Journal, 62, 891-899. [Google Scholar] [CrossRef] [PubMed]
[7] 崔琪琪, 王超, 刘双, 等. YBX1在肿瘤中的研究进展[J]. 检验医学与临床, 2021, 18(7): 880-883.
[8] 郭运生. 结肠癌细胞OXA耐药相关microRNA筛选及机制研究[D]: [博士学位论文]. 天津: 天津医科大学, 2013.
[9] 李霞, 凌天牖, 高义军. α-SMA在口腔粘膜下纤维性变成纤维细胞中的表达[J]. 中国免疫学杂志, 2007, 23(9): 851-856.
[10] Yu, C.-H., et al. (2020) LINC00312/YBX1 Axis Regulates Myofibroblast Activities in Oral Submucous Fibrosis. International Journal of Molecular Sciences, 21, 2979. [Google Scholar] [CrossRef] [PubMed]
[11] David, J.J., et al. (2012) Y-Box Binding Protein-1 Implicated in Trans-lational Control of Fetal Myocardial Gene Expression after Cardiac Transplant. Experimental Biology and Medicine (Maywood, N.J.), 237, 593-607. [Google Scholar] [CrossRef] [PubMed]
[12] Bernhardt, A., et al. (2017) Inflammatory Cell Infiltration and Res-olution of Kidney Inflammation Is Orchestrated by the Cold-Shock Protein Y-Box Binding Protein-1. Kidney Interna-tional, 92, 1157-1177. [Google Scholar] [CrossRef] [PubMed]
[13] Hanssen, L., et al. (2011) Y-Box Binding Protein-1 Mediates Pro-fibrotic Effects of Calcineurin Inhibitors in the Kidney. Journal of Immunology (Baltimore, Md.: 1950), 187, 298-308. [Google Scholar] [CrossRef] [PubMed]
[14] Xiong, P.P., et al. (2017) Positive Feedback Loop of YB-1 Inter-acting with Smad2 Promotes Liver Fibrosis. Biochemical and Biophysical Research Communications, 484, 753-761. [Google Scholar] [CrossRef] [PubMed]
[15] Chen, L.T., et al. (2019) rSjp40 Inhibits Activated Hepatic Stellate Cells by Promoting Nuclear Translocation of YB1 and Inducing BMP-7/Smad1/5/8 Pathway. Parasites & Vectors, 12, 279. [Google Scholar] [CrossRef] [PubMed]
[16] Wang, J.L., et al. (2016) Therapeutic Nuclear Shuttling of YB-1 Reduces Renal Damage and Fibrosis. Kidney International, 90, 1226-1237. [Google Scholar] [CrossRef] [PubMed]
[17] 付燕燕, 龚龙波, 孟良. CXCL1及其受体CXCR2在胃癌组织中的表达及临床意义[J]. 中国肿瘤临床, 2011, 38(13): 784-787.
[18] Hermert, D., et al. (2020) The Nucleic Acid Binding Protein YB-1-Controlled Expression of CXCL-1 Modulates Kidney Damage in Liver Fibrosis. Kidney Interna-tional, 97, 741-752. [Google Scholar] [CrossRef] [PubMed]
[19] 李汉清, 可燕. 上皮间质转化的机制研究进展[J]. 中国药理学通报, 2017, 33(10): 1342-1344.
[20] He, L., Che, M., Hu, J., et al. (2015) Twist Contributes to Proliferation and Epithelial-to-Mesenchymal Transition-Induced Fibrosis by Regulating YB-1 in Human Peritoneal Mes-othelial Cells. The American Journal of Pathology, 185, 2181-2193. [Google Scholar] [CrossRef] [PubMed]
[21] Lin, F.X., et al. (2019) YBX-1 Mediated Sorting of miR-133 into Hypoxia/Reoxygenation-Induced EPC-Derived Exosomes to Increase Fibroblast Angiogenesis and MEndoT. Stem Cell Research & Therapy, 10, 263. [Google Scholar] [CrossRef] [PubMed]
[22] Bhreathnach, U., et al. (2017) Profibrotic IHG-1 Complexes with Renal Disease Associated HSPA5 and TRAP1 in Mitochondria. Biochimica et Biophysica Acta (BBA)—Molecular Basis of Disease, 1863, 896-906. [Google Scholar] [CrossRef] [PubMed]

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