妊娠期甲状腺激素不足与子痫前期相关性研究进展
Advances in the Study of the Correlation be-tween Thyroid Hormone Deficiency in Preg-nancy and Pre-Eclampsia
摘要: 甲状腺功能异常是影响孕妇的第二大内分泌疾病，严重的甲状腺疾病会导致孕妇不良妊娠结局的出现。子痫前期与甲状腺激素不足关系密切，且都严重影响妊娠结局，文章阐述了子痫前期与妊娠期甲状腺激素不足的关系及不良结局。建议在临床工作中高度重视子痫前期患者的甲状腺功能筛查，以降低子痫前期合并甲状腺激素不足对母婴不良妊娠结局的影响，最大程度地保证母婴安全。
Abstract: Thyroid dysfunction is the second most common endocrine disease affecting pregnant women, and severe thyroid disease can lead to adverse pregnancy outcomes. Preeclampsia is closely related to thyroid hormone insufficiency, and both of them seriously affect pregnancy outcomes. This article describes the relationship between preeclampsia and thyroid hormone insufficiency during preg-nancy and adverse outcomes. It is suggested that great attention should be paid to thyroid function screening in patients with preeclampsia in clinical work, in order to reduce the impact of preeclampsia combined with thyroid hormone insufficiency on adverse pregnancy outcomes of mother and child, and to ensure the safety of mother and child to the greatest extent.
文章引用：王一涵, 王志梅, 刘雪梅. 妊娠期甲状腺激素不足与子痫前期相关性研究进展[J]. 临床医学进展, 2023, 13(3): 4559-4564. https://doi.org/10.12677/ACM.2023.133654

参考文献

[1] Chan, S. and Boelaert, K. (2014) Optimal Management of Hypothyroidism, Hypothyroxinaemia and Euthyroid TPO An-tibody Positivity Precon Ception and in Pregnancy. Clinical Endocrinology, 82, 313. [Google Scholar] [CrossRef] [PubMed]
[2] Hernandez, L., et al. (2018) Impact of TSH during the First Trimester of Pregnancy on Obstetric and Foetal Complications: Use fulness of 2.5 mIU/L Cut-Off Value. Clinical Endocrinology, 88, 728. [Google Scholar] [CrossRef] [PubMed]
[3] Vandana, K.A., Khatuja, R. and Mehta, S. (2014) Thyroid Dysfunction during Pregnancy and in Postpartum Period: Treatment and Latest Recommendations. Archives of Gynecology and Ob-stetrics, 289, 1137. [Google Scholar] [CrossRef] [PubMed]
[4] Takaoka, S., Ishii, K., et al. (2016) Clinical Features and Antenatal Risk Factors for Postpartum Onset Hypertensive Disorders. Hypertens Pregnancy, 35, 22. [Google Scholar] [CrossRef] [PubMed]
[5] 郭秋琼, 周晓莉, 何冬梅, 等. 妊娠期甲状腺功能减退症的筛查及干预对妊娠结局的影响[J]. 海南医学, 2014, 11(12): 1744-1746.
[6] 李利波, 庄晖, 李艳兰. 丙基硫氧嘧啶对妊娠合并甲状腺功能亢进孕妇甲状腺功能及妊娠结局影响的观察[J]. 中外医疗, 2014, 33(6): 1-2, 5.
[7] Li, C., Shan, Z., Mao, J., et al. (2014) Assessment of Thyroid Function during First Trimester Pregnancy: What Is the Rational Upper Limit of Serum TSH during the First Trimester in Chinese Pregnant Women. The Journal of Clini-cal Endocrinology & Metabolism, 99, 73-79. [Google Scholar] [CrossRef] [PubMed]
[8] Kintiraki, E., Papakatsika, S., Kotronis, G., et al. (2015) Pregnancy Induced Hypertension. Hormones (Athens), 14, 211. [Google Scholar] [CrossRef] [PubMed]
[9] Rhee, C.M., Brent, G.A., Kovesdy, C.P. et al. (2015) Thyroid Functional Disease: An Under-Recognized Cardiovascular Risk Factor in Kidney Disease Patients. Nephrology Dialysis Transplantation, 30, 724-737. [Google Scholar] [CrossRef] [PubMed]
[10] 成明阳. 甲状腺功能减退与子痫前期相关性的研究[D]: [硕士学位论文]. 石家庄: 河北医科大学, 2015.
[11] 佘广彤, 王慧艳. 妊娠期高血压疾病与甲状腺功能异常的临床研究[J]. 中国妇产科临床杂志, 2014, 15(4): 310-313.
[12] 崔张霞. 重度子痫前期合并甲状腺功能减退症患者的甲状腺激素水平与肾功能的相关性[J]. 中国计划生育和妇产科, 2016, 8(4): 29-31.
[13] 王芳, 曹华妹, 戴洁, 等. 重度子痫前期合并低蛋白血症对围产结局的相关分析[J]. 中国妇幼保健, 2011, 30(30): 4657-4658.
[14] 方锦莲. 重度子痫前期合并甲减孕妇的甲状腺激素水平与甲减程度的相关性研究[J]. 临床医学工程, 2015, 22(12): 1636-1637.
[15] Nazarpour, S., Tehrani, F.R., Simbar, M., et al. (2016) Thyroid and Pregnancy in Tehran, Iran: Objec-tives and Study Protocol. International Journal of Endocrinology & Metabolism, 14, 12-15. [Google Scholar] [CrossRef] [PubMed]
[16] 曲亚兰, 李丹阳. 重度子痫前期孕妇早孕期及晚孕期甲状腺功能的研究分析[J]. 系统医学, 2017, 2(2): 101-103.
[17] Mol, B.W., Roberts, C.T., Thangaratinam, S., et al. (2015) Preeclampsia. The Lancet, 42, 58-61.
[18] 许欢, 张延丽, 杨春燕. 妊娠期高血压疾病大鼠甲状腺超微结构和功能变化的联系[J]. 中国优生与遗传杂志, 2013, 21(4): 36-38.
[19] Nor Aalin, M.I., Bakin, Y.D., et al. (2010) Thyroid Auto Antibodies and Associated Complications during Pregnancy. Journal of Obstetrics and Gynaecology, 30, 675-678. [Google Scholar] [CrossRef] [PubMed]
[20] Gumieniak, O., Perlstein, T.S., Hopkins, P.N., et al. (2004) Thyroid Function and Blood Pressure Homeostasis in Euthyroid Subjects. The Journal of Clinical Endocrinology & Me-tabolism, 89, 3455-3461. [Google Scholar] [CrossRef] [PubMed]
[21] 郭雪晶, 马梓汶, 黄鹰, 等. 妊娠期甲状腺功能减退与子痫前期发病的相关性探讨[J]. 中国医药导刊, 2019, 21(9): 538-542.
[22] Algun, E., Topal, C., Oaturk, M., et al. (2004) Urinary beta-2 Micro Globulin in Renal Dysfunction Associated with Hypothyroidism. International Journal of Clinical Practice, 58, 240-243. [Google Scholar] [CrossRef] [PubMed]
[23] 肖艳春, 贾建瑞. 亚临床甲状腺功能减退症对妊娠及其结局的影响[J]. 河北医学, 2018, 24(6): 994-997.
[24] 刘金金, 崔世红, 韩笑, 等. 重度子痫前期患者甲状腺激素水平及母婴结局分析[J]. 新乡医学院学报, 2019, 36(5): 459-463.
[25] Shinohara, D.R., Santos, T.D.S., de Carvalho, H.C., et al. (2018) Pregnancy Complications Associated with Maternal Hypothyroidism: A Systematic Review. Obstet-rical & Gynecological Survey, 73, 219-230. [Google Scholar] [CrossRef] 
[26] Luisi, S., Giorgi, M., Riggi, S., et al. (2019) Neonatal Out-come in Pregnancy Hypotiroidee Women. Gynecological Endocrinology, 36, 772-775.
[27] Sitoris, G., Veltri, F., Kleynen, P., et al. (2019) The Impact of Thyroid Disorders on Poor Clinical Pregnancy Outcomes in a Real-World Study Setting. Thyroid, 30, 106-115. [Google Scholar] [CrossRef] [PubMed]
[28] Su, X., Zhao, Y., Cao, Z., et al. (2019) Association between Isolated Hypothyroxinaemia in Early Pregnancy and Perinatal Outcomes. Endocrine Connections, 8, 435-441. [Google Scholar] [CrossRef] 
[29] Gong, X., Liu, A., Li, Y., et al. (2019) The Impact of Isolated Maternal Hypothyroxinemia during the First and Second Trimester of Gestation on Pregnancy Outcomes: An Interven-tion and Prospective Cohort Study in China. Journal of Endocrinological Investigation, 42, 599-607. [Google Scholar] [CrossRef] [PubMed]
[30] 沈洁, 杨孜, 王伽略, 等. 母体基础疾病状况对子痫前期发病的影响[J]. 中华妇产科杂志, 2012, 47(6): 405-411.
[31] 李金科, 胡丽娜, 周淑, 等. 影响子痫前期围产儿结局的多因素分析[J]. 四川大学学报(医学版), 2007, 38(6): 987-990.
[32] Min, H., Dong, J., Wang, Y., et al. (2016) Ma-ternal Hypothyroxinemia-Induced Neurodevelopmental Impairments in the Progeny. Molecular Neurobiology, 53, 1613. [Google Scholar] [CrossRef] [PubMed]
[33] Su, P.-Y., et al. (2011) Maternal Thyroid Function in the First Twenty Weeks of Pregnancy and Subsequent Fetal and in Fant Development: A Prospective Population-Based Cohort Study in China. J The Journal of Clinical Endocrinology & Metabolism, 96, 323. [Google Scholar] [CrossRef] [PubMed]
[34] Haddow, J.E., Palomaki, G.E., Allan, W.C., et al. (2000) Maternal Thy-roid Deficiency during Pregnancy and Subsequent Neuropsychological Development of the Child. Obstetrical & Gyne-cological Survey, 5, 3. [Google Scholar] [CrossRef] 
[35] Mannisto, T., Mendola, P., Reddy, U., et al. (2013) Ne-onatal Outcomes and Birth Weight in Pregnancies Complicated by Maternal Thyroid Disease. American Journal of Epi-demiology, 178, 731-740. [Google Scholar] [CrossRef] [PubMed]
[36] Lazarus, J., Brown, R.S., Daumerie, C., et al. (2014) 2014 European Thyroid Association Guidelines for the Management of Subclinical Hypothyroidism in Pregnancy and in Children. European Thyroid Journal, 3, 76-94. [Google Scholar] [CrossRef] [PubMed]
[37] 张凯丽, 卢丽娟. 孕妇妊娠期甲状腺功能减退胎儿心脏功能评估的研究进展[J]. 影像研究与医学应用, 2022, 6(22): 8-10.
[38] 李国华, 黄施佳, 杜巧玲. 妊娠期甲状腺激素不足与妊娠结局的研究进展[J]. 发育医学电子杂志, 2021, 9(4): 317-320.
[39] 程媛, 桑慧歌, 王晓凤. 甲状腺功能减退症伴重度子痫前期患者的临床特点及对新生儿妊娠结局影响[J]. 中国医学工程, 2022, 30(2): 72-75. [Google Scholar] [CrossRef] 
[40] 张丽坤, 周晨红, 徐丽丽, 等. 妊娠期甲状腺功能减退孕妇甲状腺功能对子痫前期母婴预后的影响[J]. 中国妇幼保健, 2018, 33(19): 4334-4337.
[41] 刘春娟, 郑艳姬. 重度子痫前期合并甲状腺功能减退症孕妇甲状腺功能及妊娠结局比较[J]. 中南医学科学杂志, 2017, 45(4): 397-400. [Google Scholar] [CrossRef] 
[42] 孙春萍, 刘皆, 张伟, 等. 左甲状腺素钠早期治疗对妊娠合并亚临床甲状腺功能减退症妊娠结局和胎儿的影响[J]. 安徽医药, 2022, 26(12): 2520-2524.

为你推荐