中性粒细胞与淋巴细胞比值与病毒感染性疾病的研究进展
Research Progress of Neutrophil to Lymphocyte Ratio and Viral Infectious Diseases
DOI: 10.12677/ACM.2023.133655, PDF,   
作者: 李佳玉：西安医学院研究生院，陕西 西安；空军军医大学第二附属医院传染病科，陕西 西安；顾子杨, 黄长形*：空军军医大学第二附属医院传染病科，陕西 西安
关键词: 中性粒细胞与淋巴细胞比值(NLR)；感染性疾病；病毒感染；预测；Neutrophil to Lymphocyte Ratio (NLR)； Infectious Diseases； Viral Infection； Forecasting
摘要: 传统上认为中性粒细胞作为固有免疫的主力军在抵抗细菌和真菌方面起作用，越来越多的研究发现中性粒细胞在遏制和消除病毒感染方面也发挥重要作用。在很多病毒感染性疾病中，中性粒细胞增多可能标志着疾病进展。近年来与中性粒细胞相关的一种新的免疫激活标志物——中性粒细胞与淋巴细胞比值(neutrophil to lymphocyte ratio, NLR)备受人们关注。它结合了固有免疫和适应性免疫两方面，具有良好预测病情严重程度和评估临床预后的价值，并且被认为比单独中性粒细胞绝对计数或淋巴细胞绝对计数更加稳定可靠。NLR已经在很多感染性疾病中被报道，本文将重点综述COVID-19、病毒性脓毒症、SFTS、CCHF、AIDS等病毒感染中NLR的研究进展。
Abstract: Traditionally, neutrophils have been considered a major force in innate immunity, playing a role in resistance to bacteria and fungi. A growing body of research has found that neutrophils also play an influential role in containing and eliminating viral infections. In many viral infectious diseases, neutropenia may signal disease progression. In recent years, neutrophil to lymphocyte ratio (NLR), a new immune activation marker associated with neutrophils, has attracted much attention. It combines both innate and adaptive immunity, is of good value in predicting disease severity and assessing clinical prognosis, and is considered more stable and reliable than absolute neutrophil counts or absolute lymphocyte counts alone. NLR has been reported in many infectious diseases. This paper will focus on the progress of NLR in COVID-19, viral sepsis, SFTS, CCHF, AIDS and other viral infections.
文章引用：李佳玉, 顾子杨, 黄长形. 中性粒细胞与淋巴细胞比值与病毒感染性疾病的研究进展[J]. 临床医学进展, 2023, 13(3): 4565-4573. https://doi.org/10.12677/ACM.2023.133655

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