多糖水凝胶促骨修复临床进展的研究

A Study on the Clinical Progress of Polysaccharide Hydrogel Bone Promoting Repair

摘要: 由于人口老龄化的加剧，每年因骨质疏松、骨肿瘤、骨髓炎、创伤等疾病导致大量的骨缺陷或损伤。自体骨移植是骨缺损修复的金标准，但其来源有限，且可能存在术后骨质流失、创伤恢复较慢以及伤口范围较大的局限。水凝胶作为新型治疗骨缺损的材料已经取得重大成果与突破。本文总结了目前常见的4种促骨修复水凝胶材料在临床上的研究进展，分别是金针菇多糖水凝胶、壳聚糖水凝胶、葡聚糖水凝胶、海藻酸钠水凝胶。除此之外文章对于水凝胶促骨修复提出了全新的展望。

Abstract: Due to the aggravation of the aging population, a large number of bone defects or injuries are caused by osteoporosis, bone tumors, osteomyelitis, trauma and other diseases every year. Autolo-gous bone grafting is the gold standard for bone defect repair, but its sources are limited and may be limited by postoperative bone loss, slow trauma recovery, and large wound extents. As a new type of material for the treatment of bone defects, hydrogel has achieved great results and break-throughs. This article summarizes the clinical research progress of four common osteogenic hydro-gel materials, namely enoki mushroom polysaccharide hydrogel, chitosan hydrogel, dextran hy-drogel, sodium alginate hydrogel, in addition to the new prospect for hydrogel osteogenic repair.