基于网络药理学探讨辣椒抗乳腺癌的潜在机制
Exploring the Potential Mechanism of Capsicum against Breast Cancer Based on Network Pharmacology
DOI: 10.12677/TCM.2023.123108, PDF,   
作者: 董小蓉, 张甜甜, 周 刚：三峡大学健康医学院，湖北 宜昌；三峡大学中医医院/宜昌市中医医院，湖北 宜昌
关键词: 网络药理学；辣椒；乳腺癌；潜在机制；Network Pharmacology； Capsicum； Breast Cancer； Mechanism
摘要: 目的：基于网络药理学探讨辣椒抗乳腺癌的潜在作用机制。方法：在TCMSP数据库中筛选辣椒的活性化合物；利用PubChem和SwissTargetPrediction预测辣椒活性化合物的靶点基因；利用Genecards和OMIM数据库筛选疾病的靶点；利用Cytoscape 3.9.1软件构建药物–成分–靶点的可视化网络；通过STRING数据库对关键靶点构建蛋白质相互作用(PPI)网络；利用David数据库进行GO功能以及KEGG通路富集分析。结果：辣椒活性化合物共14个，药物靶点基因为270个；乳腺癌疾病靶点基因1280个；辣椒–乳腺癌共同靶点基因76个；KEGG通路富集分析显示辣椒可参与调控与乳腺癌相关的多条通路，包括P13K-AKT信号通路、HIF-1信号通路、Fox0信号通路以及Prolactin信号通路等肿瘤经典通路。结论：辣椒可能通过多个靶点、多个通路发挥抗乳腺癌的作用。
Abstract: Objective: To investigate the potential mechanism of capsicum against breast cancer based on network pharmacology. Methods: The active compounds of capsicum were screened in the TCMSP database; PubChem and SwissTargetPrediction were used to predict target genes of active compounds in capsicum; Screening targets for disease using the Genecards and OMIM databases; Cytoscape 3.9.1 software was used to build a drug-component-target visualization network; Protein interaction (PPI) networks were constructed for key targets through the STRING database; The David database was used for GO functionality and KEGG pathway enrichment analysis. Results: There were 14 active compounds in capsicum pepper, and 270 drug target genes. 1280 breast cancer disease target genes; 76 capsicum-breast cancer co-target genes; KEGG pathway enrichment analysis showed that pepper can participate in the regulation of multiple pathways related to breast cancer, including P13K-AKT signaling pathway, HIF-1 signaling pathway, Fox0 signaling pathway, and Prolactin signaling pathway and other tumor classical pathways. Conclusion: Capsicum may exert anti-breast cancer effects through multiple targets and multiple pathways.
文章引用：董小蓉, 张甜甜, 周刚. 基于网络药理学探讨辣椒抗乳腺癌的潜在机制[J]. 中医学, 2023, 12(3): 710-719. https://doi.org/10.12677/TCM.2023.123108

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