儿童肾上腺皮质癌1例并文献回顾

Adrenocortical Carcinoma in Children: One Case Report and Literature Review

摘要: 目的：了解儿童肾上腺皮质癌的临床特点、诊断及治疗方式，提高对本病的认识。方法：报道我院近期收治的1例肾上腺皮质癌患儿的临床资料，并检索中国知网、PubMed、万方等数据库，对相关文献进行回顾，归纳总结儿童肾上腺皮质癌的临床特点。结果：本例患儿以库欣综合征为首发症状，增强CT提示肾上腺区占位呈不均匀强化，行开放式手术，术后辅助依托泊苷 + 阿霉素 + 顺铂方案化疗。术后随访1年，疾病无复发。结论：肾上腺皮质癌是儿童罕见的实体肿瘤，临床特点多样，部分病例表现隐匿。其诊断需结合临床表现、实验室检查、影像学检查进行综合判断，病理检查为其诊断的金标准。手术为目前首选方式，必要时需辅助化疗、放疗等治疗。

Abstract: Objective: To understand the clinical characteristics, diagnosis and treatment of adrenocortical car-cinoma in children, and to improve the understanding of this disease. Methods: The clinical data of a child with adrenocortical carcinoma recently admitted to our hospital were reported, and the rele-vant literatures were reviewed by searching CNKI, PubMed, Wanfang and other databases, and the clinical characteristics of children with adrenocortical carcinoma were summarized. Results: In this case, Cushing’s syndrome was the first symptom. Enhanced CT revealed uneven enhancement of adrenal mass. Open surgery was performed, followed by chemotherapy with etoposide + adriamy-cin + cisplatin. The 1-year follow-up showed no recurrence of the disease. Conclusion: Adrenocorti-cal carcinoma is a rare solid tumor in children with various clinical features and hidden manifesta-tions in some cases. The diagnosis should be combined with clinical manifestations, laboratory ex-amination and imaging examination, and pathological examination is the gold standard for diagno-sis. Surgery is the preferred method at present, and adjuvant chemotherapy and radiotherapy are required if necessary.