艾司氯胺酮与围术期神经认知障碍的研究进展
Progress in the Study of Esketamine and Perioperative Neurocognitive Impairment
DOI: 10.12677/ACM.2023.134814, PDF,   
作者: 李维维, 李晓霞*：重庆医科大学附属第二医院，麻醉科，重庆
关键词: 艾司氯胺酮；围术期神经认知障碍；氯胺酮；Esketamine； Perioperative Neurocognitive Impairment； Ketamine
摘要: 随着社会老龄化及医学人文学的发展，围术期神经认知障碍逐渐进入人们的视野，成为围术期医学研究的焦点。围术期神经认知障碍指在术前及术后12个月内发生的所有神经认知功能障碍，其发病机制尚未完全明确。近年来艾司氯胺酮作为氯胺酮的异构体，因其较强的镇痛、镇静、抗炎及抗抑郁作用受到广泛重视。本文总结艾司氯胺酮的作用及作用机制，探讨艾司氯胺酮在围术期神经认知障碍产生影响的作用机制，以期探索合理的运用方式。
Abstract: With the aging of society and the development of medical humanities, perioperative neurocognitive impairment has gradually entered people’s vision and become the focus of perioperative medical research. Perioperative neurocognitive impairment refers to all neurocognitive impairment occur-ring before and within 12 months after surgery, and its pathogenesis is not completely clear. In re-cent years, as the isomer of ketamine, Esketamine has been widely recognized for its strong analge-sic, sedative, anti-inflammatory and antidepressant effects. This article summarizes the function and mechanism of Esketamine, and discusses the mechanism of its effect on neurocognitive im-pairment during perioperative period, with a view to exploring a reasonable way of use.
文章引用：李维维, 李晓霞. 艾司氯胺酮与围术期神经认知障碍的研究进展[J]. 临床医学进展, 2023, 13(4): 5769-5772. https://doi.org/10.12677/ACM.2023.134814

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