外泌体中miRNAs在缺血性脑卒中的研究进展
Research Progress of Exosomes Derived miRNAs in Ischemic Stroke
DOI: 10.12677/ACM.2023.134826, PDF,   
作者: 郭 坤：西安市中心医院神经内科，陕西 西安；延安大学医学院，陕西 延安；朱 博, 李 蓉, 郗 静：延安大学医学院，陕西 延安；王 宁, 狄政莉, 顾乃兵*：西安市中心医院神经内科，陕西 西安
关键词: 缺血性脑卒中；外泌体miRNAs；生物靶标细胞治疗；Ischemic Stroke； Exosome miRNAs； Biomaker Cell Therapy
摘要: 脑卒中在全球范围内发病率、致残率和致死率居于前列，对患者、家庭和社会造成了极大的压力和负担。外泌体作为一类广泛存在于人体血液和体液中的生物信息载体，携带有丰富的生物信息分子。在缺血性脑卒中的发生过程中，外泌体不仅积极参与并反映疾病的进展，而且在细胞间信息传递和免疫反应调节中发挥了至关重要的作用。近年来，随着对外泌体研究的不断深入，越来越多的证据表明脑卒中后外泌体中的miRNA在抑制神经细胞凋亡、促进血管新生和神经细胞修复等方面具有重要作用。因此，通过对外泌体携带的miRNA进行深入研究，探讨疾病发生和发展的相关机制，将有助于推动缺血性脑卒中预测、诊断和治疗方面的发展，进而提高患者的生活质量和生存率。本文旨在综述外泌体携带的miRNA在缺血性脑卒中诊断、治疗和预防方面的应用及其潜在价值，以期为未来相关领域的研究提供参考和启示。
Abstract: As a prevalent global health concern, stroke is characterized by high incidence, disability, and mor-tality rates, thereby imposing significant burdens on patients, families, and society at large. Exo-somes, which carry an abundance of biologically informative substances, are present in human blood and bodily fluids. In the context of ischemic stroke, exosomes not only contribute to and re-flect disease onset and progression, but also serve crucial functions in cellular information exchange and immune response modulation. Ongoing research has revealed the potential of exosome-derived miRNAs to inhibit apoptosis in nerve cells, stimulate angiogenesis, and repair damaged nerve cells. The study of exosomal miRNAs plays a vital role in elucidating the mechanisms underlying ischemic stroke and advancing the fields of prediction, diagnosis, and treatment. This review examines the applications of exosome-derived miRNAs in ischemic stroke and provides inspiration for future re-search in related fields.
文章引用：郭坤, 朱博, 李蓉, 郗静, 王宁, 狄政莉, 顾乃兵. 外泌体中miRNAs在缺血性脑卒中的研究进展[J]. 临床医学进展, 2023, 13(4): 5848-5854. https://doi.org/10.12677/ACM.2023.134826

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