黄体生成素、卵泡刺激素及LH/FSH比值在多囊卵巢综合征中的研究进展

Research Progress of Luteinizing Hormone, Follicle-Stimulating Hormone and LH/FSH Ratio in Polycystic Ovary Syndrome

摘要: 多囊卵巢综合征(PCOS)是一种由于糖代谢异常与内分泌失调引发的以高雄激素血症、稀发排卵或无排卵、胰岛素抵抗、超重或肥胖、月经不规则等为特征的一种生殖内分泌性疾病，是困扰育龄期女性难孕难育、不孕不育的重要原因之一；其中黄体生成素(LH)、卵泡刺激素(FSH)作为性激素轴中与卵巢功能密切相关的激素，在多囊卵巢综合征(PCOS)中有异于生理状态的改变，可能呈现出黄体生成素(LH)水平升高、卵泡刺激素(FSH)水平不变或降低及LH/FSH比值升高的情况；所以目前大部分研究看来黄体生成素(LH)、卵泡刺激素(FSH)及LH/FSH比值是研究甚至是诊断多囊卵巢综合征(PCOS)的重要指标，此综述总结了目前多囊卵巢综合征(PCOS)中黄体生成素(LH)、卵泡刺激素(FSH)及LH/FSH比值等指标的研究进展。

Abstract: Polycystic ovary syndrome (PCOS) is a reproductive endocrine disease caused by abnormal glucose metabolism and endocrine disorders, which is characterized by hyperandrogenism, rare ovulation or anovulation, insulin resistance, overweight or obesity, irregular menstruation, etc. It is one of the important reasons that plague women of childbearing age who are difficult to conceive, have chil-dren and have infertility. Among them, Luteinizing hormone (LH) and follicle stimulating hormone (FSH), which are closely related to ovarian function in the sex hormone axis, have different changes from the physiological state in polycystic ovary syndrome (PCOS), which may show the situation that the level of luteinizing hormone (LH) is increased, the level of follicle stimulating hormone (FSH) is unchanged or decreased, and the ratio of LH/FSH is increased. Therefore, it seems that luteinizing hormone (LH), follicle stimulating hormone (FSH) and LH/FSH ratio are important indicators for studying and even diagnosing polycystic ovary syndrome (PCOS). This review summarizes the re-search progress of luteinizing hormone (LH), follicle stimulating hormone (FSH) and LH/FSH ratio in polycystic ovary syndrome (PCOS).