结缔组织病合并血小板减少患者PLT与SII、PLR、PDW的相关性研究

Correlation between PLT and SII, PLR and PDW in Patients with Connective Tissue Disease Complicated with Thrombocytopenia

摘要: 目的：探索系统性免疫炎症指数、血小板与淋巴细胞的比值、血小板体积分布宽度在结缔组织病合并血小板减少患者中的相关性。方法：选取2015年1月至2022年8月在我院就诊的结缔组织病合并血小板减少患者作为研究对象，将血小板计数作为筛查条件，选取50 ≤ 血小板计数 < 100 × 109/L的患者分为轻度血小板减少组，选取20 ≤ 血小板计数 < 50 × 109/L的患者分为中度血小板减少组，选取血小板计数 < 20 × 109/L的患者分为重度血小板减少组，将三组间的临床数据进行比较，描述样本人群。通过斯皮尔曼分析法分析三组患者系统性免疫炎症指数、血小板与淋巴细胞的比值、血小板体积分布宽度与血小板的相关性。结果：三组系统性免疫炎症指数、血小板与淋巴细胞的比值、血小板体积分布宽度比较，差异均有统计学意义(均P < 0.05)，患者血小板数值与血小板与淋巴细胞的比值、系统性免疫炎症指数均呈正相关，与血小板体积分布宽度呈负相关。结论：结缔组织病合并血小板减少患者的血小板减少程度与系统性免疫炎症指数、血小板与淋巴细胞的比值、血小板体积分布宽度存在一定的变化规律，为评估结缔组织病患者血小板情况提供了可供参考的实验室指标。

Abstract: Objective: To explore the correlation of systemic immune inflammatory index, plate-let-to-lymphocyte ratio and platelet volume distribution width in patients with connective tissue disease and thrombocytopenia. Methods: The patients with connective tissue disease and throm-bocytopenia who were treated in our hospital from January 2015 to August 2022 were selected as the study object, and the platelet count was selected as the screening condition, and 50 ≤ platelet count < 100 × 109/L patients were divided into mild thrombocytopenia group, and 20 ≤ platelet count < 50 × 109/L patients were divided into moderate thrombocytopenia group, and platelet count < 20 × 109/L patients were divided into severe thrombocytopenia group, and the clinical data between the three groups were compared to describe the sample population. The correlation be-tween systemic immune inflammatory index, platelet-to-lymphocyte ratio and platelet volume dis-tribution width and platelet was analyzed by spearman analysis. Results: There were significant differences in systemic immune inflammatory index, platelet-to-lymphocyte ratio and platelet volume distribution width among the three groups (all P < 0.05). Conclusion: The degree of throm-bocytopenia in patients with connective tissue disease and thrombocytopenia has a certain change rule with platelet-to-lymphocyte ratio, systemic immune inflammatory index and platelet volume distribution width, which provides a reference laboratory index for evaluating the platelet condi-tion in patients with connective tissue disease.