儿童惊厥性癫痫持续状态的研究进展
Progress in the Research of Convulsive Status Epilepticus in Children
DOI: 10.12677/ACM.2023.134854, PDF,   
作者: 王 莉, 曹 洁*：重庆医科大学附属儿童医院全科，重庆；儿科学重庆市重点实验室，重庆；儿童发育疾病研究教育部重点实验室，重庆；国家儿童健康与疾病临床医学研究中心，重庆；儿童发育重大疾病国家国际科技合作基地，重庆
关键词: 惊厥性癫痫持续状态；治疗；预后；Convulsive Status Epilepticus； Treatment； Prognosis
摘要: 惊厥性癫痫持续状态是常见儿童神经系统急危重症之一，长时间惊厥发作引起脑损伤，甚至危及生命，具有较高的致死率和致残率。因此，快速止惊、积极寻找病因、改善预后至关重要。本文对儿童惊厥性癫痫持续状态病因、治疗及预后相关因素进行综述，有助于临床实践中快速终止惊厥发作并综合治疗，改善预后。
Abstract: Convulsive status epilepticus is one of the common neurological emergencies in children. Prolonged convulsive seizures cause brain damage, even life-threatening, and have a high mortality and disa-bility rate. It is very important to terminate the seizure quickly, actively search for the cause, and improve the prognosis. This article reviews the etiology, treatment and prognostic factors, which is helpful to quickly stop convulsion and comprehensive treatment in clinical practice and improve the outcomes.
文章引用：王莉, 曹洁. 儿童惊厥性癫痫持续状态的研究进展[J]. 临床医学进展, 2023, 13(4): 6059-6064. https://doi.org/10.12677/ACM.2023.134854

参考文献

[1] Lv, R.-J., Wang, Q., Tao, C., Fei, Z. and Shao, X.-Q. (2017) Status Epilepticus-Related Etiology, Incidence and Mortality: A Meta-Analysis. Epilepsy Research, 136, 12-17. [Google Scholar] [CrossRef] [PubMed]
[2] Martinos, M., Pujar, S., O’reilly, H., de Haan, M., Neville, B., Scott, R. and Chin, R. (2019) Intelligence and Memory Outcomes within 10 Years of Childhood Convulsive Status Epilepticus. Epilepsy & Behavior, 95, 18-25. [Google Scholar] [CrossRef] [PubMed]
[3] Saz, E.-U., Karapinar, B., Ozcetin, M., et al. (2011) Convulsive Status Epilepticus in Children: Etiology, Treatment Protocol and Outcome. Seizure, 20, 115-118. [Google Scholar] [CrossRef] [PubMed]
[4] 李琼, 葛娜, 张菲菲, 张旭. 咪达唑仑联合苯巴比妥、地西泮治疗小儿惊厥性癫痫持续状态的临床研究[J]. 临床误诊误治, 2019, 32(9): 31-34.
[5] 詹玉, 胡越. 儿童惊厥持续状态预后不良相关因素的预后研究质量分析[J]. 癫痫杂志, 2021, 7(2): 112-121.
[6] 朱海霞, 李小晶, 王秀英. 儿童惊厥性癫痫持续状态的病因及其预后的影响因素[J]. 广西医学, 2017, 39(8): 1160-1163.
[7] 陈飞燕, 高玉婷, 陈友海. 惊厥性癫痫持续状态的临床特征及预后影响因素分析[J]. 海南医学, 2020, 31(5): 597-599.
[8] Kravljanac, R., Jovic, N., Tadic, B., Kravljanac, D. and Pekmezovic, T. (2018) New-Onset Seizure Pre-senting as Status Epilepticus: Etiology and Clinical Characteristics in a Cohort of 236 Children. Seizure, 63, 79-84. [Google Scholar] [CrossRef] [PubMed]
[9] International League against Epilepsy Commission on Epidemi-ology and Prognosis (1993) Guidelines for Epidemiologic Studies on Epilepsy. Epilepsia, 34, 592-596.
[10] Trinka, E., Cock, H., Hesdorffer, D., et al. (2015) A Definition and Classification of Status Epilepticus—Report of the ILAE Task Force on Classification of Status Epilepticus. Epilepsia, 56, 1515-1523. [Google Scholar] [CrossRef] [PubMed]
[11] Bilgi, A., et al. (2018) Psychiatric Symptoms and Health-Related Quality of Life in Children with Epilepsy and Their Mothers. Epilepsy & Behavior, 80, 114-121. [Google Scholar] [CrossRef] [PubMed]
[12] Ng, Y.-T. and Maganti, R. (2013) Status Epilepticus in Childhood. Journal of Paediatrics & Child Health, 49, 432-437. [Google Scholar] [CrossRef] [PubMed]
[13] Trinka, E. and Klviinen, R. (2017) 25 Years of Advances in the Definition, Classification and Treatment of Status Epilepticus. Seizure, 44, 65. [Google Scholar] [CrossRef] [PubMed]
[14] 束晓梅. 儿童癫痫持续状态的病因学[J]. 中华实用儿科临床杂志, 2017, 32(12): 886-888.
[15] Freilich, E.-R., Schreiber, J.-M., Zelleke, T. and Gaillard, W.-D. (2014) Pediatric Status Epilepticus: Identification and Evaluation. Current Opinion in Pediatrics, 26, 655-661. [Google Scholar] [CrossRef] 
[16] Gavrielov-Yusim, N., Hoshen, M., Singer, S.-R., Neumann, L. and Balicer, R.-D. (2014) The Weight of MMRV-Related Febrile Convulsions among Other Clinical Factors Contrib-uting to Febrile Convulsions in Children. Vaccine, 32, 4954-4959. [Google Scholar] [CrossRef] [PubMed]
[17] Sánchez-Fernández, I., Goodkin, H.P. and Scott, R.C. (2019) Pathophysiology of Convulsive Status Epilepticus. Seizure, 68, 16-21. [Google Scholar] [CrossRef] [PubMed]
[18] Sasidaran, K., Singhi, S. and Singhi, P. (2012) Management of Acute Seizure and Status Epilepticus in Pediatric Emergency. Indian Journal of Pediatrics, 79, 510-517. [Google Scholar] [CrossRef] [PubMed]
[19] 赵骋. 儿童癫痫持续状态的研究进展[J]. 国际儿科学杂志, 2017, 44(8): 527-530.
[20] Glauser, T., Shinnar, S., Gloss, D., et al. (2016) Evidence-Based Guideline: Treatment of Convulsive Status Epilepticus in Children and Adults: Report of the Guideline Committee of the American Epilepsy So-ciety. Epilepsy Currents, 16, 48-61. [Google Scholar] [CrossRef] [PubMed]
[21] 姜玉武. 儿童惊厥性癫痫持续状态——难题与决策[J]. 医学与哲学, 2010, 31(16): 5-9.
[22] Abend, N.S. and Loddenkemper, T. (2014) Man-agement of Pediatric Status Epilepticus. Current Treatment Options in Neurology, 16, 301. [Google Scholar] [CrossRef] [PubMed]
[23] 杨会阳, 束晓梅. 儿童惊厥性癫痫持续状态的病因及治疗进展[J]. 海南医学, 2019, 30(7): 921-924.
[24] 贾鑫磊, 钱素云. 麻醉剂在难治性癫痫持续状态的应用[J]. 中国小儿急救医学, 2016, 23(11): 727-730, 735.
[25] Tripathi, M., Vibha, D., Choudhary, N., et al. (2010) Management of Re-fractory Status Epilepticus at a Tertiary Care Centre in a Developing Country. Seizure, 19, 109-111. [Google Scholar] [CrossRef] [PubMed]
[26] Ferlisi, M., et al. (2012) The Outcome of Therapies in Refractory and Super-Refractory Convulsive Status Epilepticus and Recommendations for Therapy. Brain: A Journal of Neurology, 135, 2314-2328.
[27] Caraballo, R.-H., Flesler, S., Armeno, M., et al. (2014) Ketogenic Diet in Pediatric Patients with Refractory Focal Status Epilepticus. Epilepsy Research, 108, 1912-1916. [Google Scholar] [CrossRef] [PubMed]
[28] Legriel, S., Lemiale, V., Schenck, M., et al. (2016) Hypo-thermia for Neuroprotection in Convulsive Status Epilepticus. New England Journal of Medicine, 375, 2457-2467. [Google Scholar] [CrossRef] 
[29] Reddy, Y., Balakrishna, Y. and Mubaiwa, L. (2017) Convulsive Status Epilepticus in a Quaternary Hospital Paediatric Intensive Care Unit (PICU) in South Africa: An 8 Year Review. Seizure, 51, 55-60. [Google Scholar] [CrossRef] [PubMed]
[30] Maegaki, Y., et al. (2015) Early Predictors of Status Epilepti-cus-Associated Mortality and Morbidity in Children. Brain & Development, 37, 478-486. [Google Scholar] [CrossRef] [PubMed]
[31] Shah, S., Shah, N., Johnson, R., et al. (2016) Single Center Outcomes of Status Epilepticus at a Paediatric Intensive Care Unit. Canadian Journal of Neurological Sciences, 43, 105-112. [Google Scholar] [CrossRef] [PubMed]
[32] Sunit, S., et al. (2017) Clinical Profile and Neurodevelopmental Outcome of New-Onset Acute Symptomatic Seizures in Children. Seizure, 50, 130-136. [Google Scholar] [CrossRef] [PubMed]
[33] Specchio, N., Pietrafusa, N, Bellusci, M., et al. (2019) Pediatric Status Epilepticus: Identification of Prognostic Factors Using the New ILAE Classification after 5 Years of Follow-Up. Epilepsia, 60, 2486-2498. [Google Scholar] [CrossRef] [PubMed]
[34] Wang, T.Q., Wang, J., Dou, Y.L., et al. (2020) Clinical Characteristics and Prognosis in a Large Paediatric Cohort with Status Epilepticus. Seizure: European Journal of Epilepsy, 80, 5-11. [Google Scholar] [CrossRef] [PubMed]

为你推荐