瓜蒌薤白白酒汤从温通之法治疗冠心病心绞痛临床疗效meta分析

Meta Analysis of Clinical Efficacy of Gualou Xiebai Baijiu Decoction in Treating Coronary Heart Disease and Angina

摘要: 目的：对瓜蒌薤白白酒汤从温通之法治疗冠心病心绞痛的临床疗效、血脂水平(TC)、血液流变学情况(高血全切黏度)进行系统评价。方法：通过RevMan5.3软件对所包含的数据进行Meta分析。数据的提取从建库到2023年03月01日，数据主要从中国知网数据库，VIP-Data，中国生物医药文献数据库，万方数据库，PubMed、The Cochrane Library等进行提取。结果：经过对相关文献提取后，总计纳入12篇文献，共1166例患者，从Meta分析结果得出，瓜蒌薤白白酒汤能提高冠心病心绞痛患者临床疗效：RR = 0.35，95%CI (0.26, 0.46)，改善患者血脂水平(TC) SMD = −1.28，95%CI (−1.71, −0.84)和血液流变学情况(高血全切黏度) SMD = −0.66，95%CI (−1.11, −0.20)。结论：瓜蒌薤白白酒汤从温通法辅助治疗冠心病心绞痛，比西药常规治疗冠心病有较好的临床疗效，同时对患者血脂水平(TC)及血液流变学情况(高血全切黏度)也有显著改善。

Abstract: Objective: To systematically evaluate the clinical efficacy, blood lipid level (TC), and hemorheology (high total shear viscosity) of Gualou Xiebai Baijiu Decoction in the treatment of coronary heart disease angina pectoris from warming to dredging. Methods: Meta-analysis was performed on the data contained by RevMan5.3 software. The data was extracted from the establishment of the da-tabase to March 1, 2023. The data were mainly extracted from the CNKI database, VIP-Data, China Biomedical Literature Database, Wanfang Database, PubMed, The Cochrane Library, etc. Results: After the extraction of the relevant literature, a total of 12 articles were included in 1166 patients. From the Meta analysis results, Gualou Xiebai Baijiu Decoction can improve the clinical efficacy of patients with coronary heart disease and angina pectoris: RR = 0.35, 95%CI (0.26, 0.46), improve the level of blood lipids (TC) SMD = −1.28, 95%CI (−1.71, −0.84) and hemorheology (high total shear viscosity) SMD = −0.66, 95%CI (−1.11, −0.20). Conclusion: Gualou Xiebai Baijiu Decoction has a better clinical effect than conventional western medicine in the auxiliary treatment of coronary heart disease angina pectoris from warming and unblocking method, and it also significantly improves the blood lipid level (TC) and hemorheology (high total shear viscosity) of patients.