细胞外体积分数在肿瘤相关领域中的应用进展

Advances in the Application of Extracellular Volume Fraction in Tumor-Related Fields

摘要: 恶性肿瘤(癌症)是威胁人类健康的重要原因之一，全面的了解肿瘤生物学行为，明确肿瘤的发生发展机制，有利于我们制定全面的战略和措施应对癌症带来的日益增长的死亡威胁。细胞外基质(extracellular matrix, ECM)在肿瘤的生物化学、生物力学、结构组成和分布上发生改变，它参与促进肿瘤细胞的生长、侵袭、转移和血管生成，而且抵抗细胞死亡和药物扩散。细胞外体积分数(Extracellular volume fraction, ECV)可以量化ECM，基于影像学检查的ECV分数与组织病理上的ECV具有较高的一致性，具有无创、定量、可重复等优点，在肿瘤相关预测因子、组织病理分级分化、复发转移及疗效评估等方面广泛应用，本文对ECV在肿瘤相关领域的应用进行了阐述和总结。

Abstract: Malignant tumors (cancer) are one of the most important causes of threats to human health. A comprehensive understanding of tumor biological behavior and clarification of the mechanisms of tumor development are beneficial for us to develop comprehensive strategies and measures to deal with the increasing threat of death from cancer. Extracellular matrix (ECM) is altered in the biochemistry, biomechanics, structural composition and distribution of tumors, and it is involved in promoting tumor cell growth, invasion, metastasis and angiogenesis, and it resists cell death and drug diffusion. Extracellular volume fraction (ECV) can quantify ECM, and ECV fraction based on imaging examination has high consistency with ECV on histopathology, which has the advantages of non-invasive, quantitative and reproducible, and is widely used in tumor-related predictors, histopathological grading and differentiation, recurrence and metastasis, and efficacy assessment, etc. In this paper, the application of ECV in tumor-related fields is described and summarized.