高强度聚焦超声治疗的研究进展
Research Advances in High Intensity Focused Ultrasound Therapy
摘要: 高强度聚焦超声可以通过体外高强度的超声波将能量聚焦于病变部位,使病变部位发生凝固性坏死,同时尽量减少对目标区域以外的组织的损害,由此达到治疗的目的。并且在超声和磁共振的指导下,高强度聚焦超声聚焦病变组织的精确度更高,治疗效果和安全性更可靠。高强度聚焦超声作为一种无创、安全的治疗方式,已广泛应用于实体肿瘤和良性疾病。本文简单回顾了高强度聚焦超声的发展历史和工作的基本原理,介绍了高强度聚焦超声治疗设备,以及简要论述了高强度聚焦超声在各种肿瘤和良性疾病中的临床应用。
Abstract: High-intensity focused ultrasound can be used to focus energy on the lesion through high-intensity ultrasound outside the body, causing coagulative necrosis of the lesion while minimizing damage to tissue outside the target area, thereby achieving treatment. Guided by ultrasound and magnetic resonance, high intensity focused ultrasound can focus on the lesion with greater precision and re-liability of treatment and safety. As a non-invasive and safe treatment modality, high-intensity fo-cused ultrasound has been widely used in solid tumours and benign diseases. This article briefly reviews the history of the development and basic principles of high-intensity focused ultrasound, introduces high-intensity focused ultrasound treatment devices, and briefly discusses the clinical applications of high-intensity focused ultrasound in various tumours and benign diseases.
文章引用:夏梦, 孙江川. 高强度聚焦超声治疗的研究进展[J]. 临床医学进展, 2023, 13(4): 6261-6265. https://doi.org/10.12677/ACM.2023.134881

参考文献

[1] Shehata Elhelf, I.A., Albahar, H., Shah, U., et al. (2018) High Intensity Focused Ultrasound: The Fundamentals, Clinical Applications and Research Trends. Diagnostic and Interventional Imaging, 99, 349-359. [Google Scholar] [CrossRef] [PubMed]
[2] 贾淑平, 赵亮, 蒋荷娟. 高强度聚焦超声消融术在肿瘤治疗方面的应用进展[J]. 中国医疗器械信息, 2019, 25(9): 48-50.
[3] Lee, J.Y., Chung, H.H., Kang, S.Y., et al. (2020) Portable Ultrasound-Guided High-Intensity Focused Ultrasound with Functions for Safe and Rapid Ablation: Prospec-tive Clinical Trial for Uterine Fibroids—Short-Term and Long-Term Results. European Radiology, 30, 1554-1563. [Google Scholar] [CrossRef] [PubMed]
[4] Shah, B.., Lehman, V.T., Kaufmann, T.J., et al. (2020) Ad-vanced MRI Techniques for Transcranial High Intensity Focused Ultrasound Targeting. Brain, 143, 2664-2672. [Google Scholar] [CrossRef] [PubMed]
[5] Anneveldt, K.J., van’t Oever, H.J., Nijholt, I.M., et al. (2021) System-atic Review of Reproductive Outcomes after High Intensity Focused Ultrasound Treatment of Uterine Fibroids. Europe-an Journal of Radiology, 141, Article ID: 109801. [Google Scholar] [CrossRef] [PubMed]
[6] Dosanjh, A., Harvey, P., Baldwin, S., et al. (2021) High-Intensity Focused Ultrasound for the Treatment of Prostate Cancer: A Na-tional Cohort Study Focusing on the Development of Stricture and Fistulae. European Urology Focus, 7, 340-346. [Google Scholar] [CrossRef] [PubMed]
[7] Shi, S., Ni, G., Ling, L., et al. (2020) High-Intensity Focused Ul-trasound in the Treatment of Abdominal Wall Endometriosis. Journal of Minimally Invasive Gynecology, 27, 704-711. [Google Scholar] [CrossRef] [PubMed]
[8] 贾淑平, 赵亮, 蒋荷娟. 高强度聚焦超声消融术在肿瘤治疗方面的应用进展[J]. 中国医疗器械信息, 2019, 25(9): 48-50.
[9] Izadifar, Z., Izadifar, Z., Chapman, D. and Babyn, P. (2020) An Introduction to High Intensity Focused Ultrasound: Systematic Review on Principles, Devices, and Clinical Applications. Journal of Clinical Medicine, 9, Article No. 460. [Google Scholar] [CrossRef] [PubMed]
[10] 高强度聚焦超声肿瘤治疗系统临床应用指南(试行) [J]. 中华医学杂志, 2005(12): 796-797.
[11] Jun, M.-J., Shim, J.H., Kim, S.Y., et al. (2014) Clinical Implications of Preoperative and Intraoperative Liver Biopsies for Evaluating Donor Steatosis in Living Related Liver Transplantation. Liver Transplanta-tion, 20, 437-445. [Google Scholar] [CrossRef] [PubMed]
[12] Wu, F., Chen, W.-Z., Bai, J., et al. (2001) Pathological Changes in Human Malignant Carcinoma Treated with High- Intensity Focused Ultrasound. Ultrasound in Medicine & Biology, 27, 1099-1106. [Google Scholar] [CrossRef
[13] Luo, Y. and Jiang, Y. (2019) Comparison of Efficiency of TACE plus HIFU and TACE Alone on Patients with Primary Liver Cancer. Journal of the College of Physicians and Surgeons Pakistan, 29, 414-417. [Google Scholar] [CrossRef] [PubMed]
[14] Wu, F., Wang, Z.-B., Chen, W.-Z., et al. (2005) Advanced Hepa-tocellular Carcinoma: Treatment with High-Intensity Focused Ultrasound Ablation Combined with Transcatheter Arterial Embolization. Radiology, 235, 659-667. [Google Scholar] [CrossRef] [PubMed]
[15] Wu, F., Wang, Z.-B., Zhu, H., et al. (2005) Extracorporeal High Intensity Focused Ultrasound Treatment for Patients with Breast Cancer. Breast Cancer Research and Treatment, 92, 51-60. [Google Scholar] [CrossRef] [PubMed]
[16] Peek, M., Ahmed, M. and Douek, M. (2015) Circumferen-tial High Intensity Focused Ultrasound (HIFU) in the Treatment of Breast Fibroadenomata: The HIFU-F Trial. European Journal of Surgical Oncology, 41, S51. [Google Scholar] [CrossRef
[17] Madersbacher, S., Schatzl, G., Djavan, B., Stulnig, T. and Mar-berger, M. (2000) Long-Term Outcome of Transrectal High-Intensity Focused Ultrasound Therapy for Benign Prostatic Hyperplasia. European Urology, 37, 687-694. [Google Scholar] [CrossRef] [PubMed]
[18] Guillaumier, S., Peters, M., Arya, M., et al. (2018) A Multicentre Study of 5-Year Outcomes Following Focal Therapy in Treating Clinically Significant Nonmetastatic Prostate Cancer. European Urology, 74, 422-429. [Google Scholar] [CrossRef] [PubMed]
[19] 徐小娟, 刘晓芳, 何佳. 高强度聚焦超声治疗子宫肌瘤2年随访结果分析[J]. 中国实用妇科与产科杂志, 2018, 34(2): 214-218.
[20] Liu, X., Tang, J., Luo, Y., Wang, Y., Song, L. and Wang, W. (2020) Comparison of High-Intensity Focused Ultrasound Ablation and Secondary Myomectomy for Recurrent Symptomatic Uterine Fibroids Following Myomectomy: A Retrospective Study. BJOG: An International Journal of Obstetrics & Gynaecology, 127, 1422-1428. [Google Scholar] [CrossRef] [PubMed]
[21] 刘政, 田锦, 张惠, 米成嵘. 利用超声造影评估高强度聚焦超声和子宫动脉栓塞治疗子宫肌瘤疗效差异[J]. 实用妇产科杂志, 2019, 35(8): 633-638.
[22] 许温馨, 邹敏, 熊郁, 等. 高强度聚焦超声治疗后子宫肌瘤患者妊娠情况分析[J]. 中国实用妇科与产科杂志, 2019, 35(1): 117-122.
[23] Jiang, Z., Li, Q., Li, W., et al. (2021) A Comparative Analysis of Pregnancy Outcomes of Patients with Uterine Fibroids after High Intensity Focused Ultrasound Ablation and Laparoscopic Myomectomy: A Retrospective Study. International Journal of Hyperthermia, 38, 79-84. [Google Scholar] [CrossRef] [PubMed]
[24] Liu, Y., Ran, W., Shen, Y., Feng, W. and Yi, J. (2017) High-Intensity Focused Ultrasound and Laparoscopic Myomectomy in the Treatment of Uterine Fibroids: A Comparative Study. BJOG: An International Journal of Obstetrics & Gynaecology, 124, 36-39. [Google Scholar] [CrossRef] [PubMed]
[25] Wang, Y.-B., Ma, R., Wang, Z.-B., et al. (2022) Transcatheter Arte-rial Chemoembolization in Combination with High- Intensity Focused Ultrasound for Intermediate and Advanced Hepa-tocellular Carcinoma: A Meta-Analysis. Frontiers in Oncology, 12, Article 797349. [Google Scholar] [CrossRef] [PubMed]
[26] 中国医师协会聚焦超声消融手术临床应用技术规范制定专家委员会. 聚焦超声消融手术临床应用技术规范专家共识(2020年版) [J]. 中华医学杂志, 2020, 100(13): 974-977.
[27] Liu, Y., Zhang, W.W., He, M., et al. (20180 Adverse Effect Analysis of High-Intensity Focused Ultra-sound in the Treatment of Benign Uterine Diseases. International Journal of Hyperthermia, 35, 56-61.[CrossRef] [PubMed]