妊娠期合并症的代谢组学研究进展
Advances in Metabonomics of Pregnancy Complications
DOI: 10.12677/ACM.2023.134886, PDF,   
作者: 屈奕彤：大连医科大学研究生学院，辽宁 大连；山东省康复大学青岛医院(青岛市市立医院)妇产科，山东 青岛；陶 红*：山东省康复大学青岛医院(青岛市市立医院)妇产科，山东 青岛
关键词: 代谢组学；串联质谱；妊娠期高血压疾病；妊娠期糖尿病；Metabolomics； Tandem Mass Spectrometry； Hypertensive Disorder Complicating Pregnancy； Gestational Diabetes Mellitus
摘要: 我国高龄孕产妇的数量呈逐年上升趋势，这极大增加了妊娠期合并症的发病率，而妊娠期合并症主要为代谢相关性疾病，这正是代谢组学成为新兴发展领域的主要原因。代谢组学可以反应机体对内外界刺激产生的一系列生理或病理过程，从机体代谢产物的种类变化以及水平差异来判断疾病进展情况。同时，代谢组学也可在疾病发生前通过标志性代谢产物的变化提前预测该病的发生发展及严重程度，有效降低妊娠期合并症的发病率，为母胎近期及远期的健康提供更多保障。
Abstract: The number of elderly pregnant women in our country is increasing year by year, which greatly in-creases the incidence of pregnancy complications, which are mainly metabolic-related diseases, this is the main reason why metabolomics is an emerging field. Metabonomics can reflect a series of physiological or pathological processes produced by internal and external stimuli, and judge the progress of diseases from the variety and level difference of metabolites. At the same time, metabo-lomics can predict the development and severity of the disease in advance by the change of the marker metabolite, which can effectively reduce the incidence of pregnancy complications, to pro-vide greater protection for the immediate and long-term health of the mother and the foetus.
文章引用：屈奕彤, 陶红. 妊娠期合并症的代谢组学研究进展[J]. 临床医学进展, 2023, 13(4): 6296-6304. https://doi.org/10.12677/ACM.2023.134886

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